Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases
Th17 cells are generally considered to be positive regulators of immune responses because they produce pro-inflammatory cytokines, including IL-17A, IL-17F, and IL-22. Cytokine production not only promotes accumulation of immune cells, such as macrophages, neutrophils and lymphocytes, at inflammator...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01112/full |
| _version_ | 1819104804594515968 |
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| author | Xinyu Wu Xinyu Wu Jie Tian Shengjun Wang Shengjun Wang |
| author_facet | Xinyu Wu Xinyu Wu Jie Tian Shengjun Wang Shengjun Wang |
| author_sort | Xinyu Wu |
| collection | DOAJ |
| description | Th17 cells are generally considered to be positive regulators of immune responses because they produce pro-inflammatory cytokines, including IL-17A, IL-17F, and IL-22. Cytokine production not only promotes accumulation of immune cells, such as macrophages, neutrophils and lymphocytes, at inflammatory sites but can also cause tissue pathologies. Conversely, certain Th17 cells can also negatively regulate immune responses by secreting immunosuppressive factors, such as IL-10; these cells are termed non-pathogenic Th17 cells. In this review, we summarize recent advances in the development and regulatory functions of non-pathogenic Th17 cells in autoimmune diseases. |
| first_indexed | 2024-12-22T02:12:10Z |
| format | Article |
| id | doaj.art-34e22ead1be0455abdbc0065a0d3f47b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T02:12:10Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-34e22ead1be0455abdbc0065a0d3f47b2022-12-21T18:42:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.01112352276Insight Into Non-Pathogenic Th17 Cells in Autoimmune DiseasesXinyu Wu0Xinyu Wu1Jie Tian2Shengjun Wang3Shengjun Wang4Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaTh17 cells are generally considered to be positive regulators of immune responses because they produce pro-inflammatory cytokines, including IL-17A, IL-17F, and IL-22. Cytokine production not only promotes accumulation of immune cells, such as macrophages, neutrophils and lymphocytes, at inflammatory sites but can also cause tissue pathologies. Conversely, certain Th17 cells can also negatively regulate immune responses by secreting immunosuppressive factors, such as IL-10; these cells are termed non-pathogenic Th17 cells. In this review, we summarize recent advances in the development and regulatory functions of non-pathogenic Th17 cells in autoimmune diseases.https://www.frontiersin.org/article/10.3389/fimmu.2018.01112/fullTh17 cellsIL-10inflammationimmunosuppressionautoimmune diseases |
| spellingShingle | Xinyu Wu Xinyu Wu Jie Tian Shengjun Wang Shengjun Wang Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases Frontiers in Immunology Th17 cells IL-10 inflammation immunosuppression autoimmune diseases |
| title | Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases |
| title_full | Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases |
| title_fullStr | Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases |
| title_full_unstemmed | Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases |
| title_short | Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases |
| title_sort | insight into non pathogenic th17 cells in autoimmune diseases |
| topic | Th17 cells IL-10 inflammation immunosuppression autoimmune diseases |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01112/full |
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