Yellow Fever Virus Vaccine Reduces T Cell Receptor Signaling and the Levels of Phosphatase PTPRE In Vivo

Yellow Fever Virus Vaccine Reduces T Cell Receptor Signaling and the Levels of Phosphatase PTPRE In Vivo

<strong>Background:</strong> A Src kinase-activating phosphatase (PTPRE) is targeted by a genome-derived yellow fever virus (YFV) short noncoding RNA (vsRNA) in vitro. The vsRNA reduces PTPRE translation, which leads to reduced TCR signaling. vsRNA point mutations restore PTPRE expressio...

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Bibliographic Details
Main Authors: Jinhua Xiang, James H. McLinden, Qing Chang, Thomas M Kaufman, Judy A. Streit, Jack T. Stapleton
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Proceedings
Subjects:
yellow fever virus
restriction factor
PTPRE
noncoding RNA
yellow fever vaccine
Online Access:https://www.mdpi.com/2504-3900/50/1/97

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