A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B
Cortex pseudolaricis, the root bark of Pseudolarix kaempferi Gord, has been used to treat tinea and other skin diseases for the antimicrobial activities in Traditional Chinese Medicine (TCM). Pseudolaric acid B (PAB) has been identified as the major component responsible for the action of C. pseudol...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-06-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00394/full |
| _version_ | 1811279967035588608 |
|---|---|
| author | Mei-lun Liu Dan Sun Tan Li Hong Chen |
| author_facet | Mei-lun Liu Dan Sun Tan Li Hong Chen |
| author_sort | Mei-lun Liu |
| collection | DOAJ |
| description | Cortex pseudolaricis, the root bark of Pseudolarix kaempferi Gord, has been used to treat tinea and other skin diseases for the antimicrobial activities in Traditional Chinese Medicine (TCM). Pseudolaric acid B (PAB) has been identified as the major component responsible for the action of C. pseudolaricis. Recently, PAB has been demonstrated to be used as novel treatments for cancer, immune disorders, inflammatory diseases, and immunosuppression. However, the mechanisms through which PAB exerts its properties are not understood well, and little attention in the literature has been given to review its pharmacological activities before. In this review, we performed a systematic summary of the literature with respect to the anticancer, immunosuppressive and anti-inflammatory properties of PAB and its derivatives. Currently available data suggest that PAB is a promising immunosuppressive and anti-inflammatory agent candidate and should be explored further in cancer treatment and prevention. |
| first_indexed | 2024-04-13T01:05:18Z |
| format | Article |
| id | doaj.art-34e44559c57349d69037a0af16dceb91 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T01:05:18Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-34e44559c57349d69037a0af16dceb912022-12-22T03:09:22ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122017-06-01810.3389/fphar.2017.00394265155A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid BMei-lun Liu0Dan Sun1Tan Li2Hong Chen3Department of Pharmacognosy and Pharmaceutics, Logistics University of the Chinese People's Armed Police ForceTianjin, ChinaDepartment of Pharmacognosy and Pharmaceutics, Logistics University of the Chinese People's Armed Police ForceTianjin, ChinaDepartment of Pathogen Biology and Immunology, Logistics University of the Chinese People's Armed Police ForceTianjin, ChinaDepartment of Pharmacognosy and Pharmaceutics, Logistics University of the Chinese People's Armed Police ForceTianjin, ChinaCortex pseudolaricis, the root bark of Pseudolarix kaempferi Gord, has been used to treat tinea and other skin diseases for the antimicrobial activities in Traditional Chinese Medicine (TCM). Pseudolaric acid B (PAB) has been identified as the major component responsible for the action of C. pseudolaricis. Recently, PAB has been demonstrated to be used as novel treatments for cancer, immune disorders, inflammatory diseases, and immunosuppression. However, the mechanisms through which PAB exerts its properties are not understood well, and little attention in the literature has been given to review its pharmacological activities before. In this review, we performed a systematic summary of the literature with respect to the anticancer, immunosuppressive and anti-inflammatory properties of PAB and its derivatives. Currently available data suggest that PAB is a promising immunosuppressive and anti-inflammatory agent candidate and should be explored further in cancer treatment and prevention.http://journal.frontiersin.org/article/10.3389/fphar.2017.00394/fulltraditional chinese medicinepseudolaric acid Bcancerinflammationimmunoregulation |
| spellingShingle | Mei-lun Liu Dan Sun Tan Li Hong Chen A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B Frontiers in Pharmacology traditional chinese medicine pseudolaric acid B cancer inflammation immunoregulation |
| title | A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B |
| title_full | A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B |
| title_fullStr | A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B |
| title_full_unstemmed | A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B |
| title_short | A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B |
| title_sort | systematic review of the immune regulating and anticancer activities of pseudolaric acid b |
| topic | traditional chinese medicine pseudolaric acid B cancer inflammation immunoregulation |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00394/full |
| work_keys_str_mv | AT meilunliu asystematicreviewoftheimmuneregulatingandanticanceractivitiesofpseudolaricacidb AT dansun asystematicreviewoftheimmuneregulatingandanticanceractivitiesofpseudolaricacidb AT tanli asystematicreviewoftheimmuneregulatingandanticanceractivitiesofpseudolaricacidb AT hongchen asystematicreviewoftheimmuneregulatingandanticanceractivitiesofpseudolaricacidb AT meilunliu systematicreviewoftheimmuneregulatingandanticanceractivitiesofpseudolaricacidb AT dansun systematicreviewoftheimmuneregulatingandanticanceractivitiesofpseudolaricacidb AT tanli systematicreviewoftheimmuneregulatingandanticanceractivitiesofpseudolaricacidb AT hongchen systematicreviewoftheimmuneregulatingandanticanceractivitiesofpseudolaricacidb |