De novo electrocardiographic abnormalities in persons living with HIV
Abstract Persons living with HIV (PLWH) may have increased incidence of cardiovascular events and longer QTc intervals than uninfected persons. We aimed to investigate the incidence and risk factors of de novo major electrocardiogram (ECG) abnormalities and QTc prolongation in well-treated PLWH. We...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-00290-x |
| _version_ | 1818838226189680640 |
|---|---|
| author | Andreas D. Knudsen Claus Graff Jonas Bille Nielsen Magda Teresa Thomsen Julie Høgh Thomas Benfield Jan Gerstoft Lars Køber Klaus F. Kofoed Susanne D. Nielsen |
| author_facet | Andreas D. Knudsen Claus Graff Jonas Bille Nielsen Magda Teresa Thomsen Julie Høgh Thomas Benfield Jan Gerstoft Lars Køber Klaus F. Kofoed Susanne D. Nielsen |
| author_sort | Andreas D. Knudsen |
| collection | DOAJ |
| description | Abstract Persons living with HIV (PLWH) may have increased incidence of cardiovascular events and longer QTc intervals than uninfected persons. We aimed to investigate the incidence and risk factors of de novo major electrocardiogram (ECG) abnormalities and QTc prolongation in well-treated PLWH. We included virologically suppressed PLWH without major ECG abnormalities, who attended the 2-year follow-up in the Copenhagen comorbidity in HIV infection (COCOMO) study. ECGs were categorized according to Minnesota Code Manual. We defined de novo major ECG abnormalities as new major Minnesota Code Manual abnormalities. Prolonged QTc was defined as QTc > 460 ms in females and QTc > 450 ms in males. Of 667 PLWH without major ECG abnormalities at baseline, 34 (5%) developed de novo major ECG abnormalities after a median of 2.3 years. After adjustment, age (RR: 1.57 [1.08–2.28] per decade older), being underweight (RR: 5.79 [1.70–19.71]), current smoking (RR: 2.34 [1.06–5.16]), diabetes (RR: 3.89 [1.72–8.80]) and protease inhibitor use (RR: 2.45 [1.27–4.74) were associated with higher risk of getting de novo major ECG abnormalities. Of PLWH without prolonged QTc at baseline, only 11 (1.6%) participants developed de novo prolonged QTc. Five percent of well-treated PLWH acquired de novo major ECG abnormalities and protease inhibitor use was associated with more than twice the risk of de novo major ECG abnormalities. De novo prolonged QTc was rare and did not seem to constitute a problem in well-treated PLWH. |
| first_indexed | 2024-12-19T03:35:01Z |
| format | Article |
| id | doaj.art-34e46885faf2412ba6bed813a066fe5e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T03:35:01Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-34e46885faf2412ba6bed813a066fe5e2022-12-21T20:37:25ZengNature PortfolioScientific Reports2045-23222021-10-011111810.1038/s41598-021-00290-xDe novo electrocardiographic abnormalities in persons living with HIVAndreas D. Knudsen0Claus Graff1Jonas Bille Nielsen2Magda Teresa Thomsen3Julie Høgh4Thomas Benfield5Jan Gerstoft6Lars Køber7Klaus F. Kofoed8Susanne D. Nielsen9Viro-immunology Research Unit, Department of Infectious Diseases 8632, Copenhagen University Hospital, Rigshospitalet, University of CopenhagenDepartment of Health Science and Technology, Aalborg UniversityDepartment of Cardiology, The Heart Center, Rigshospitalet, University of CopenhagenViro-immunology Research Unit, Department of Infectious Diseases 8632, Copenhagen University Hospital, Rigshospitalet, University of CopenhagenViro-immunology Research Unit, Department of Infectious Diseases 8632, Copenhagen University Hospital, Rigshospitalet, University of CopenhagenDepartment of Infectious Diseases, Hvidovre Hospital, University of CopenhagenViro-immunology Research Unit, Department of Infectious Diseases 8632, Copenhagen University Hospital, Rigshospitalet, University of CopenhagenDepartment of Cardiology, The Heart Center, Rigshospitalet, University of CopenhagenDepartment of Cardiology, The Heart Center, Rigshospitalet, University of CopenhagenViro-immunology Research Unit, Department of Infectious Diseases 8632, Copenhagen University Hospital, Rigshospitalet, University of CopenhagenAbstract Persons living with HIV (PLWH) may have increased incidence of cardiovascular events and longer QTc intervals than uninfected persons. We aimed to investigate the incidence and risk factors of de novo major electrocardiogram (ECG) abnormalities and QTc prolongation in well-treated PLWH. We included virologically suppressed PLWH without major ECG abnormalities, who attended the 2-year follow-up in the Copenhagen comorbidity in HIV infection (COCOMO) study. ECGs were categorized according to Minnesota Code Manual. We defined de novo major ECG abnormalities as new major Minnesota Code Manual abnormalities. Prolonged QTc was defined as QTc > 460 ms in females and QTc > 450 ms in males. Of 667 PLWH without major ECG abnormalities at baseline, 34 (5%) developed de novo major ECG abnormalities after a median of 2.3 years. After adjustment, age (RR: 1.57 [1.08–2.28] per decade older), being underweight (RR: 5.79 [1.70–19.71]), current smoking (RR: 2.34 [1.06–5.16]), diabetes (RR: 3.89 [1.72–8.80]) and protease inhibitor use (RR: 2.45 [1.27–4.74) were associated with higher risk of getting de novo major ECG abnormalities. Of PLWH without prolonged QTc at baseline, only 11 (1.6%) participants developed de novo prolonged QTc. Five percent of well-treated PLWH acquired de novo major ECG abnormalities and protease inhibitor use was associated with more than twice the risk of de novo major ECG abnormalities. De novo prolonged QTc was rare and did not seem to constitute a problem in well-treated PLWH.https://doi.org/10.1038/s41598-021-00290-x |
| spellingShingle | Andreas D. Knudsen Claus Graff Jonas Bille Nielsen Magda Teresa Thomsen Julie Høgh Thomas Benfield Jan Gerstoft Lars Køber Klaus F. Kofoed Susanne D. Nielsen De novo electrocardiographic abnormalities in persons living with HIV Scientific Reports |
| title | De novo electrocardiographic abnormalities in persons living with HIV |
| title_full | De novo electrocardiographic abnormalities in persons living with HIV |
| title_fullStr | De novo electrocardiographic abnormalities in persons living with HIV |
| title_full_unstemmed | De novo electrocardiographic abnormalities in persons living with HIV |
| title_short | De novo electrocardiographic abnormalities in persons living with HIV |
| title_sort | de novo electrocardiographic abnormalities in persons living with hiv |
| url | https://doi.org/10.1038/s41598-021-00290-x |
| work_keys_str_mv | AT andreasdknudsen denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT clausgraff denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT jonasbillenielsen denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT magdateresathomsen denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT juliehøgh denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT thomasbenfield denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT jangerstoft denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT larskøber denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT klausfkofoed denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv AT susannednielsen denovoelectrocardiographicabnormalitiesinpersonslivingwithhiv |