Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain
BackgroundTreatment with immune checkpoint inhibitors (ICI) can induce durable responses in cancer patients, but it is commonly associated with serious immune-related side effects. Both effects are suggested to be mediated by CD8+ T-cell infiltration. Whole body CD8+ T-cell distribution can be visua...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199282/full |
| _version_ | 1797813718802759680 |
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| author | K. F. Bol E. Peeters C. M. L. van Herpen H. Westdorp E. H. J. G. Aarntzen |
| author_facet | K. F. Bol E. Peeters C. M. L. van Herpen H. Westdorp E. H. J. G. Aarntzen |
| author_sort | K. F. Bol |
| collection | DOAJ |
| description | BackgroundTreatment with immune checkpoint inhibitors (ICI) can induce durable responses in cancer patients, but it is commonly associated with serious immune-related side effects. Both effects are suggested to be mediated by CD8+ T-cell infiltration. Whole body CD8+ T-cell distribution can be visualized by PET imaging of a 89Zr-labeled anti-humanCD8a minibody, currently investigated in a phase 2b trial.Main bodyAn adult patient diagnosed with metastatic melanoma developed ICI-related hypophysitis after two courses of combined immunotherapy (ipilimumab (3 mg/kg) and nivolumab (1 mg/kg) at 3 weeks interval). On a [89Zr]Zr-crefmirlimab berdoxam PET/CT scan, made 8 days before clinical symptoms occurred, increased CD8+ T-cell infiltration in the pituitary gland was detected. Simultaneously, tracer uptake in a cerebral metastasis was increased, indicating ICI-induced tumor infiltration by CD8+ T-cells.ConclusionsThe observations in this case report underscore the role of CD8+ T-cell in non-tumor tissues in ICI-related toxicity. In addition, it illustrates a potential role for molecular imaging by PET/CT for investigation and monitoring of ICI-induced effects. |
| first_indexed | 2024-03-13T07:55:57Z |
| format | Article |
| id | doaj.art-34e4fbaea57f47d6b008451fd7eb520f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T07:55:57Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-34e4fbaea57f47d6b008451fd7eb520f2023-06-02T04:32:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.11992821199282Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brainK. F. Bol0E. Peeters1C. M. L. van Herpen2H. Westdorp3E. H. J. G. Aarntzen4Medical Oncology, Radboudumc, Nijmegen, NetherlandsMedical Imaging, Radboudumc, Nijmegen, NetherlandsMedical Oncology, Radboudumc, Nijmegen, NetherlandsMedical Oncology, Radboudumc, Nijmegen, NetherlandsMedical Imaging, Radboudumc, Nijmegen, NetherlandsBackgroundTreatment with immune checkpoint inhibitors (ICI) can induce durable responses in cancer patients, but it is commonly associated with serious immune-related side effects. Both effects are suggested to be mediated by CD8+ T-cell infiltration. Whole body CD8+ T-cell distribution can be visualized by PET imaging of a 89Zr-labeled anti-humanCD8a minibody, currently investigated in a phase 2b trial.Main bodyAn adult patient diagnosed with metastatic melanoma developed ICI-related hypophysitis after two courses of combined immunotherapy (ipilimumab (3 mg/kg) and nivolumab (1 mg/kg) at 3 weeks interval). On a [89Zr]Zr-crefmirlimab berdoxam PET/CT scan, made 8 days before clinical symptoms occurred, increased CD8+ T-cell infiltration in the pituitary gland was detected. Simultaneously, tracer uptake in a cerebral metastasis was increased, indicating ICI-induced tumor infiltration by CD8+ T-cells.ConclusionsThe observations in this case report underscore the role of CD8+ T-cell in non-tumor tissues in ICI-related toxicity. In addition, it illustrates a potential role for molecular imaging by PET/CT for investigation and monitoring of ICI-induced effects.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199282/fullPET/CT imagingimmune checkpoint inhibitorsCD8+ T-cellstoxicitymelanoma |
| spellingShingle | K. F. Bol E. Peeters C. M. L. van Herpen H. Westdorp E. H. J. G. Aarntzen Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain Frontiers in Immunology PET/CT imaging immune checkpoint inhibitors CD8+ T-cells toxicity melanoma |
| title | Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain |
| title_full | Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain |
| title_fullStr | Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain |
| title_full_unstemmed | Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain |
| title_short | Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain |
| title_sort | case report imaging immune checkpoint inhibitor induced yin yang effects in the brain |
| topic | PET/CT imaging immune checkpoint inhibitors CD8+ T-cells toxicity melanoma |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199282/full |
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