High-dose simvastatin therapy effectiveness in early post-infarction angina treatment
Aim. To study the early effects of simvastatin therapy (80 mg/d) on the clinical symptoms of early post-myocardial infarction (post-AMI) angina, as well as on the in-hospital prognosis. Material and methods. In total, 60 patients with acute myocardial infarction (AMI) were divided into two groups: G...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2011-10-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1933 |
| _version_ | 1797882583939284992 |
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| author | A. G. Nikishin M. M. Pirnazarov T. M. Mamarasulov |
| author_facet | A. G. Nikishin M. M. Pirnazarov T. M. Mamarasulov |
| author_sort | A. G. Nikishin |
| collection | DOAJ |
| description | Aim. To study the early effects of simvastatin therapy (80 mg/d) on the clinical symptoms of early post-myocardial infarction (post-AMI) angina, as well as on the in-hospital prognosis. Material and methods. In total, 60 patients with acute myocardial infarction (AMI) were divided into two groups: Group I (n=30) receiving standard therapy (simvastatin 20 mg/d) and Group II (n=30) receiving high doses of simvastatin (80 mg/d). Clinical symptoms of post-AMI angina were assessed using a scale by O.V. Voennov, at baseline and at Day 10 of the treatment. In-hospital prognosis was assessed by the following criteria: death, reinfarction, persistent angina, or a combination of these parameters. Results. Aggressive statin therapy in Group II was associated with a significant decrease in post-AMI angina score (from 7,30±0,55 % to 1,20±0,37 %), reduced incidence of angina attacks at rest and after meals, and reduced pain intensity, compared to Group I. In-hospital incidence of reinfarction was 20,0±7,4 % (n=6) and 0 % (n=0) in Groups I and II, respectively (р=0,01). Conclusion. High-dose simvastatin therapy (80 mg/d) demonstrated beneficial effects on clinical symptoms of post-AMI angina and in-hospital AMI prognosis, compared to the lower-dose simvastatin treatment (20 mg/d). |
| first_indexed | 2024-04-10T03:38:08Z |
| format | Article |
| id | doaj.art-34e5daea5fb642e0b375a814cc408f3a |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:38:08Z |
| publishDate | 2011-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-34e5daea5fb642e0b375a814cc408f3a2023-03-13T07:23:20Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252011-10-01105262910.15829/1728-8800-2011-5-26-291645High-dose simvastatin therapy effectiveness in early post-infarction angina treatmentA. G. Nikishin0M. M. Pirnazarov1T. M. Mamarasulov2Республиканский специализированный центр кардиологииРеспубликанский специализированный центр кардиологииРеспубликанский специализированный центр кардиологииAim. To study the early effects of simvastatin therapy (80 mg/d) on the clinical symptoms of early post-myocardial infarction (post-AMI) angina, as well as on the in-hospital prognosis. Material and methods. In total, 60 patients with acute myocardial infarction (AMI) were divided into two groups: Group I (n=30) receiving standard therapy (simvastatin 20 mg/d) and Group II (n=30) receiving high doses of simvastatin (80 mg/d). Clinical symptoms of post-AMI angina were assessed using a scale by O.V. Voennov, at baseline and at Day 10 of the treatment. In-hospital prognosis was assessed by the following criteria: death, reinfarction, persistent angina, or a combination of these parameters. Results. Aggressive statin therapy in Group II was associated with a significant decrease in post-AMI angina score (from 7,30±0,55 % to 1,20±0,37 %), reduced incidence of angina attacks at rest and after meals, and reduced pain intensity, compared to Group I. In-hospital incidence of reinfarction was 20,0±7,4 % (n=6) and 0 % (n=0) in Groups I and II, respectively (р=0,01). Conclusion. High-dose simvastatin therapy (80 mg/d) demonstrated beneficial effects on clinical symptoms of post-AMI angina and in-hospital AMI prognosis, compared to the lower-dose simvastatin treatment (20 mg/d).https://cardiovascular.elpub.ru/jour/article/view/1933острый инфаркт миокардапостинфарктная стенокардияагрессивная терапиясимвастатин |
| spellingShingle | A. G. Nikishin M. M. Pirnazarov T. M. Mamarasulov High-dose simvastatin therapy effectiveness in early post-infarction angina treatment Кардиоваскулярная терапия и профилактика острый инфаркт миокарда постинфарктная стенокардия агрессивная терапия симвастатин |
| title | High-dose simvastatin therapy effectiveness in early post-infarction angina treatment |
| title_full | High-dose simvastatin therapy effectiveness in early post-infarction angina treatment |
| title_fullStr | High-dose simvastatin therapy effectiveness in early post-infarction angina treatment |
| title_full_unstemmed | High-dose simvastatin therapy effectiveness in early post-infarction angina treatment |
| title_short | High-dose simvastatin therapy effectiveness in early post-infarction angina treatment |
| title_sort | high dose simvastatin therapy effectiveness in early post infarction angina treatment |
| topic | острый инфаркт миокарда постинфарктная стенокардия агрессивная терапия симвастатин |
| url | https://cardiovascular.elpub.ru/jour/article/view/1933 |
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