Activating the interleukin-6-Gp130-STAT3 pathway ameliorates ventricular electrical stability in myocardial infarction rats by modulating neurotransmitters in the paraventricular nucleus

Activating the interleukin-6-Gp130-STAT3 pathway ameliorates ventricular electrical stability in myocardial infarction rats by modulating neurotransmitters in the paraventricular nucleus

Abstract Background Malignant ventricular arrhythmia (VA) is the most common cause of death associated with acute myocardial infarction (MI). Recent studies have revealed direct involvement of the paraventricular nucleus (PVN) in the occurrence of VA. However, the underlying mechanisms remain incomp...

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Bibliographic Details
Main Authors: Meng Gao, Dechun Yin, Jugang Chen, Xiufen Qu
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Cardiovascular Disorders
Subjects:
Hypothalamic paraventricular nucleus
Interleukin-6
Glycoprotein 130
STAT3
Sympathetic activity
Cardiac electrophysiological activity
Online Access:https://doi.org/10.1186/s12872-020-01363-x

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