Therapeutic Impact of Costus (Saussurea lappa) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice
Breast cancer remains the most common cause of cancer deaths among women globally. Ehrlich solid tumor (EST) is a transplantable tumor model for simulating breast cancer. This study aims to describe the protective role of costus (Saussurea lappa) root against EST-induced cardiac toxicity. Forty fema...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.708785/full |
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| author | Rehab M. Elgharabawy Rehab M. Elgharabawy Ibrahim El Tantawy El Sayed Nada Abd-Allah Rezk Ehab Tousson |
| author_facet | Rehab M. Elgharabawy Rehab M. Elgharabawy Ibrahim El Tantawy El Sayed Nada Abd-Allah Rezk Ehab Tousson |
| author_sort | Rehab M. Elgharabawy |
| collection | DOAJ |
| description | Breast cancer remains the most common cause of cancer deaths among women globally. Ehrlich solid tumor (EST) is a transplantable tumor model for simulating breast cancer. This study aims to describe the protective role of costus (Saussurea lappa) root against EST-induced cardiac toxicity. Forty female mice were randomly and equally divided into four groups (G1, control group; G2, costus group; G3, EST group; G4, EST + costus). The results showed that compared to the control, EST induced a significant increase in lactate dehydrogenase, creatine kinase, creatine kinase myoglobin, aspartate aminotransferase, and alkaline phosphatase activities; in potassium, chloride ion, cholesterol, triglyceride, and low density lipoprotein levels; in DNA damage and cardiac injury; and in p53 and vascular endothelial growth factor expression. Conversely, EST induced a significant decrease in sodium ion and high density lipoprotein levels and Ki67 expression compared to the control. Treatment of EST with costus improved cardiac toxicity, lipid profiles, electrolytes, and apoptosis, and protected against EST. This indicates the potential benefits of costus as an adjuvant in the prevention and treatment of cardiac toxicity. |
| first_indexed | 2024-12-20T23:37:29Z |
| format | Article |
| id | doaj.art-34e74912e4de4b94ae189d025724617c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T23:37:29Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-34e74912e4de4b94ae189d025724617c2022-12-21T19:23:10ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-06-011210.3389/fphar.2021.708785708785Therapeutic Impact of Costus (Saussurea lappa) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female MiceRehab M. Elgharabawy0Rehab M. Elgharabawy1Ibrahim El Tantawy El Sayed2Nada Abd-Allah Rezk3Ehab Tousson4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, EgyptDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Burydah, Saudi ArabiaChemistry Department, Faculty of Science, Menoufia University, Shibin El Kom, EgyptChemistry Department, Faculty of Science, Menoufia University, Shibin El Kom, EgyptZoology Department, Faculty of Science, Tanta, EgyptBreast cancer remains the most common cause of cancer deaths among women globally. Ehrlich solid tumor (EST) is a transplantable tumor model for simulating breast cancer. This study aims to describe the protective role of costus (Saussurea lappa) root against EST-induced cardiac toxicity. Forty female mice were randomly and equally divided into four groups (G1, control group; G2, costus group; G3, EST group; G4, EST + costus). The results showed that compared to the control, EST induced a significant increase in lactate dehydrogenase, creatine kinase, creatine kinase myoglobin, aspartate aminotransferase, and alkaline phosphatase activities; in potassium, chloride ion, cholesterol, triglyceride, and low density lipoprotein levels; in DNA damage and cardiac injury; and in p53 and vascular endothelial growth factor expression. Conversely, EST induced a significant decrease in sodium ion and high density lipoprotein levels and Ki67 expression compared to the control. Treatment of EST with costus improved cardiac toxicity, lipid profiles, electrolytes, and apoptosis, and protected against EST. This indicates the potential benefits of costus as an adjuvant in the prevention and treatment of cardiac toxicity.https://www.frontiersin.org/articles/10.3389/fphar.2021.708785/fullehrlich solid tumorcostus rootcardiac functionsapoptosisKi67 expression |
| spellingShingle | Rehab M. Elgharabawy Rehab M. Elgharabawy Ibrahim El Tantawy El Sayed Nada Abd-Allah Rezk Ehab Tousson Therapeutic Impact of Costus (Saussurea lappa) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice Frontiers in Pharmacology ehrlich solid tumor costus root cardiac functions apoptosis Ki67 expression |
| title | Therapeutic Impact of Costus (Saussurea lappa) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice |
| title_full | Therapeutic Impact of Costus (Saussurea lappa) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice |
| title_fullStr | Therapeutic Impact of Costus (Saussurea lappa) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice |
| title_full_unstemmed | Therapeutic Impact of Costus (Saussurea lappa) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice |
| title_short | Therapeutic Impact of Costus (Saussurea lappa) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice |
| title_sort | therapeutic impact of costus saussurea lappa against ehrlich solid tumor induced cardiac toxicity and dna damage in female mice |
| topic | ehrlich solid tumor costus root cardiac functions apoptosis Ki67 expression |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.708785/full |
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