Transcranial electrical stimulation accelerates human sleep homeostasis.
The sleeping brain exhibits characteristic slow-wave activity which decays over the course of the night. This decay is thought to result from homeostatic synaptic downscaling. Transcranial electrical stimulation can entrain slow-wave oscillations (SWO) in the human electro-encephalogram (EEG). A com...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS Computational Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23459152/pdf/?tool=EBI |
| _version_ | 1818388202672619520 |
|---|---|
| author | Davide Reato Fernando Gasca Abhishek Datta Marom Bikson Lisa Marshall Lucas C Parra |
| author_facet | Davide Reato Fernando Gasca Abhishek Datta Marom Bikson Lisa Marshall Lucas C Parra |
| author_sort | Davide Reato |
| collection | DOAJ |
| description | The sleeping brain exhibits characteristic slow-wave activity which decays over the course of the night. This decay is thought to result from homeostatic synaptic downscaling. Transcranial electrical stimulation can entrain slow-wave oscillations (SWO) in the human electro-encephalogram (EEG). A computational model of the underlying mechanism predicts that firing rates are predominantly increased during stimulation. Assuming that synaptic homeostasis is driven by average firing rates, we expected an acceleration of synaptic downscaling during stimulation, which is compensated by a reduced drive after stimulation. We show that 25 minutes of transcranial electrical stimulation, as predicted, reduced the decay of SWO in the remainder of the night. Anatomically accurate simulations of the field intensities on human cortex precisely matched the effect size in different EEG electrodes. Together these results suggest a mechanistic link between electrical stimulation and accelerated synaptic homeostasis in human sleep. |
| first_indexed | 2024-12-14T04:22:06Z |
| format | Article |
| id | doaj.art-34ea132cd2854702a26245bf173eca2c |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-14T04:22:06Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-34ea132cd2854702a26245bf173eca2c2022-12-21T23:17:19ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582013-01-0192e100289810.1371/journal.pcbi.1002898Transcranial electrical stimulation accelerates human sleep homeostasis.Davide ReatoFernando GascaAbhishek DattaMarom BiksonLisa MarshallLucas C ParraThe sleeping brain exhibits characteristic slow-wave activity which decays over the course of the night. This decay is thought to result from homeostatic synaptic downscaling. Transcranial electrical stimulation can entrain slow-wave oscillations (SWO) in the human electro-encephalogram (EEG). A computational model of the underlying mechanism predicts that firing rates are predominantly increased during stimulation. Assuming that synaptic homeostasis is driven by average firing rates, we expected an acceleration of synaptic downscaling during stimulation, which is compensated by a reduced drive after stimulation. We show that 25 minutes of transcranial electrical stimulation, as predicted, reduced the decay of SWO in the remainder of the night. Anatomically accurate simulations of the field intensities on human cortex precisely matched the effect size in different EEG electrodes. Together these results suggest a mechanistic link between electrical stimulation and accelerated synaptic homeostasis in human sleep.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23459152/pdf/?tool=EBI |
| spellingShingle | Davide Reato Fernando Gasca Abhishek Datta Marom Bikson Lisa Marshall Lucas C Parra Transcranial electrical stimulation accelerates human sleep homeostasis. PLoS Computational Biology |
| title | Transcranial electrical stimulation accelerates human sleep homeostasis. |
| title_full | Transcranial electrical stimulation accelerates human sleep homeostasis. |
| title_fullStr | Transcranial electrical stimulation accelerates human sleep homeostasis. |
| title_full_unstemmed | Transcranial electrical stimulation accelerates human sleep homeostasis. |
| title_short | Transcranial electrical stimulation accelerates human sleep homeostasis. |
| title_sort | transcranial electrical stimulation accelerates human sleep homeostasis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23459152/pdf/?tool=EBI |
| work_keys_str_mv | AT davidereato transcranialelectricalstimulationaccelerateshumansleephomeostasis AT fernandogasca transcranialelectricalstimulationaccelerateshumansleephomeostasis AT abhishekdatta transcranialelectricalstimulationaccelerateshumansleephomeostasis AT marombikson transcranialelectricalstimulationaccelerateshumansleephomeostasis AT lisamarshall transcranialelectricalstimulationaccelerateshumansleephomeostasis AT lucascparra transcranialelectricalstimulationaccelerateshumansleephomeostasis |