Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
Quint et al. use zebrafish lines deficient in one of two orthologs of the Gap Junction Delta-2 (GJD2) gene, which is associated with myopia by genome-wide association studies. They link gjd2 with refractive error and report evidence to suggest that gjd2a plays a role in ocular biometry whilst gjd2b,...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02185-z |
| _version_ | 1818434100821753856 |
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| author | Wim H. Quint Kirke C. D. Tadema Erik de Vrieze Rachel M. Lukowicz Sanne Broekman Beerend H. J. Winkelman Melanie Hoevenaars H. Martijn de Gruiter Erwin van Wijk Frank Schaeffel Magda Meester-Smoor Adam C. Miller Rob Willemsen Caroline C. W. Klaver Adriana I. Iglesias |
| author_facet | Wim H. Quint Kirke C. D. Tadema Erik de Vrieze Rachel M. Lukowicz Sanne Broekman Beerend H. J. Winkelman Melanie Hoevenaars H. Martijn de Gruiter Erwin van Wijk Frank Schaeffel Magda Meester-Smoor Adam C. Miller Rob Willemsen Caroline C. W. Klaver Adriana I. Iglesias |
| author_sort | Wim H. Quint |
| collection | DOAJ |
| description | Quint et al. use zebrafish lines deficient in one of two orthologs of the Gap Junction Delta-2 (GJD2) gene, which is associated with myopia by genome-wide association studies. They link gjd2 with refractive error and report evidence to suggest that gjd2a plays a role in ocular biometry whilst gjd2b, previously found in the retina, possesses an additional lenticular role. |
| first_indexed | 2024-12-14T16:31:38Z |
| format | Article |
| id | doaj.art-34eb9c818e744750bea9066079088f6f |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T16:31:38Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-34eb9c818e744750bea9066079088f6f2022-12-21T22:54:35ZengNature PortfolioCommunications Biology2399-36422021-06-014111410.1038/s42003-021-02185-zLoss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafishWim H. Quint0Kirke C. D. Tadema1Erik de Vrieze2Rachel M. Lukowicz3Sanne Broekman4Beerend H. J. Winkelman5Melanie Hoevenaars6H. Martijn de Gruiter7Erwin van Wijk8Frank Schaeffel9Magda Meester-Smoor10Adam C. Miller11Rob Willemsen12Caroline C. W. Klaver13Adriana I. Iglesias14Department of Ophthalmology, Erasmus Medical CenterDepartment of Ophthalmology, Erasmus Medical CenterDepartment of Otorhinolaryngology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical CenterInstitute of Neuroscience, University of OregonDepartment of Otorhinolaryngology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical CenterDepartment of Ophthalmology, Erasmus Medical CenterDepartment of Ophthalmology, Erasmus Medical CenterOptical Imaging Centre, Erasmus Medical CenterDepartment of Otorhinolaryngology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical CenterInstitute for Ophthalmic Research, University of TübingenDepartment of Ophthalmology, Erasmus Medical CenterInstitute of Neuroscience, University of OregonDepartment of Clinical Genetics, Erasmus Medical CenterDepartment of Ophthalmology, Erasmus Medical CenterDepartment of Ophthalmology, Erasmus Medical CenterQuint et al. use zebrafish lines deficient in one of two orthologs of the Gap Junction Delta-2 (GJD2) gene, which is associated with myopia by genome-wide association studies. They link gjd2 with refractive error and report evidence to suggest that gjd2a plays a role in ocular biometry whilst gjd2b, previously found in the retina, possesses an additional lenticular role.https://doi.org/10.1038/s42003-021-02185-z |
| spellingShingle | Wim H. Quint Kirke C. D. Tadema Erik de Vrieze Rachel M. Lukowicz Sanne Broekman Beerend H. J. Winkelman Melanie Hoevenaars H. Martijn de Gruiter Erwin van Wijk Frank Schaeffel Magda Meester-Smoor Adam C. Miller Rob Willemsen Caroline C. W. Klaver Adriana I. Iglesias Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish Communications Biology |
| title | Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish |
| title_full | Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish |
| title_fullStr | Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish |
| title_full_unstemmed | Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish |
| title_short | Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish |
| title_sort | loss of gap junction delta 2 gjd2 gene orthologs leads to refractive error in zebrafish |
| url | https://doi.org/10.1038/s42003-021-02185-z |
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