Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles
While resin-based materials meet the many requirements of a restorative material, they lack adequate, long-lasting antimicrobial power. This study investigated a zinc oxide nanoparticle (ZnO NP)-loaded resin-blend (RB) toward a new antimicrobial photodynamic therapy (aPDT)-based approach for managin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/15/14/5075 |
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| author | Patricia Comeau Julia Burgess Niknaz Malekafzali Maria Luisa Leite Aidan Lee Adriana Manso |
| author_facet | Patricia Comeau Julia Burgess Niknaz Malekafzali Maria Luisa Leite Aidan Lee Adriana Manso |
| author_sort | Patricia Comeau |
| collection | DOAJ |
| description | While resin-based materials meet the many requirements of a restorative material, they lack adequate, long-lasting antimicrobial power. This study investigated a zinc oxide nanoparticle (ZnO NP)-loaded resin-blend (RB) toward a new antimicrobial photodynamic therapy (aPDT)-based approach for managing dental caries. The results confirmed that up to 20 wt% ZnO NPs could be added without compromising the degree of conversion (DC) of the original blend. The DC achieved for the 20 wt% ZnO NP blend has been the highest reported. The effects on flexural strength (FS), shear bond strength to dentin (SBS), water sorption (WS), solubility (SL), and viability of <i>Streptococcus mutans</i> under 1.35 J/cm<sup>2</sup> blue light or dark conditions were limited to ≤20 wt% ZnO NP loading. The addition of up to 20 wt% ZnO NPs had a minimal impact on FS or SBS, while a reduction in the bacteria count was observed. The maximum loading resulted in an increase in SL. Furthermore, 28-day aging in 37 °C water increased the FS for all groups, while it sustained the reduction in bacteria count for the 20 wt% resin blends. Overall, the ZnO NP-loaded resin-based restorative material presents significant potential for use in aPDT. |
| first_indexed | 2024-03-09T13:26:05Z |
| format | Article |
| id | doaj.art-34ec1677daf04cedb9833c44e0e2f036 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T13:26:05Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-34ec1677daf04cedb9833c44e0e2f0362023-11-30T21:23:01ZengMDPI AGMaterials1996-19442022-07-011514507510.3390/ma15145075Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO NanoparticlesPatricia Comeau0Julia Burgess1Niknaz Malekafzali2Maria Luisa Leite3Aidan Lee4Adriana Manso5Department of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC V6T 1Z3, CanadaWhile resin-based materials meet the many requirements of a restorative material, they lack adequate, long-lasting antimicrobial power. This study investigated a zinc oxide nanoparticle (ZnO NP)-loaded resin-blend (RB) toward a new antimicrobial photodynamic therapy (aPDT)-based approach for managing dental caries. The results confirmed that up to 20 wt% ZnO NPs could be added without compromising the degree of conversion (DC) of the original blend. The DC achieved for the 20 wt% ZnO NP blend has been the highest reported. The effects on flexural strength (FS), shear bond strength to dentin (SBS), water sorption (WS), solubility (SL), and viability of <i>Streptococcus mutans</i> under 1.35 J/cm<sup>2</sup> blue light or dark conditions were limited to ≤20 wt% ZnO NP loading. The addition of up to 20 wt% ZnO NPs had a minimal impact on FS or SBS, while a reduction in the bacteria count was observed. The maximum loading resulted in an increase in SL. Furthermore, 28-day aging in 37 °C water increased the FS for all groups, while it sustained the reduction in bacteria count for the 20 wt% resin blends. Overall, the ZnO NP-loaded resin-based restorative material presents significant potential for use in aPDT.https://www.mdpi.com/1996-1944/15/14/5075dental materialmethacrylate-based monomerszinc oxide nanoparticlesphotosensitivephotocatalyticantimicrobial |
| spellingShingle | Patricia Comeau Julia Burgess Niknaz Malekafzali Maria Luisa Leite Aidan Lee Adriana Manso Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles Materials dental material methacrylate-based monomers zinc oxide nanoparticles photosensitive photocatalytic antimicrobial |
| title | Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles |
| title_full | Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles |
| title_fullStr | Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles |
| title_full_unstemmed | Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles |
| title_short | Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles |
| title_sort | exploring the physicochemical mechanical and photocatalytic antibacterial properties of a methacrylate based dental material loaded with zno nanoparticles |
| topic | dental material methacrylate-based monomers zinc oxide nanoparticles photosensitive photocatalytic antimicrobial |
| url | https://www.mdpi.com/1996-1944/15/14/5075 |
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