Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study
Objectives This study aimed to assess the association between longitudinal change in non-high-density lipoprotein cholesterol (non-HDL-C) and subsequent cardiovascular disease (CVD) risk.Design A retrospective study.Setting Data were obtained from the Kailuan Study, a dynamic cohort study initiated...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-04-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/4/e069807.full |
| _version_ | 1826987055732752384 |
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| author | Yun Li Hui Zhou Qing Yue Xiaoxu Ma Xiong Ding Zhe Shu |
| author_facet | Yun Li Hui Zhou Qing Yue Xiaoxu Ma Xiong Ding Zhe Shu |
| author_sort | Yun Li |
| collection | DOAJ |
| description | Objectives This study aimed to assess the association between longitudinal change in non-high-density lipoprotein cholesterol (non-HDL-C) and subsequent cardiovascular disease (CVD) risk.Design A retrospective study.Setting Data were obtained from the Kailuan Study, a dynamic cohort study initiated in 2006 in Tangshan, China.Participants The current study included 41 085 participants (mean age 53.9±11.6 years) free of CVD events in or before 2012. The non-HDL-C trajectory was developed according to the repeated measurement during 2006–2012 surveys to predict the CVD risk from 2012 to 2020.Primary outcome measures CVD events included myocardial infarction and stroke.Results 3 discrete non-HDL-C trajectories were identified: low-increasing (n=20 038), moderate-increasing (n=17 987) and high-increasing (n=3060). During 8 years of follow-up, 1797 CVD events were documented. Relative to the low-increasing pattern, adjusted HRs were 1.25 (95% CI: 1.13 to 1.38) for the moderate-increasing pattern and 1.46 (95% CI: 1.24 to 1.71) for the high-increasing pattern after adjustment for potential confounders such as age, sex, education background, smoking status, drinking status, physical activity, body mass index, low-density lipoprotein cholesterol, hypertension, diabetes and lipid-lowering medications.Conclusions Changes in non-HDL-C were significantly associated with subsequent risk of CVD events, and participants with a high-increasing pattern had a higher CVD risk. Long-term monitoring of non-HDL-C could be useful to improve the prediction of CVD risk.Trial registration number ChiCTR-TNC-1100148. |
| first_indexed | 2024-04-09T15:52:47Z |
| format | Article |
| id | doaj.art-34ecf4c506e24b95a3e7c4e768057829 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-02-18T07:32:15Z |
| publishDate | 2023-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-34ecf4c506e24b95a3e7c4e7680578292024-11-06T06:30:09ZengBMJ Publishing GroupBMJ Open2044-60552023-04-0113410.1136/bmjopen-2022-069807Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan StudyYun Li0Hui Zhou1Qing Yue2Xiaoxu Ma3Xiong Ding4Zhe Shu5Nanjing Lishui People`s Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, Jiangsu Province, ChinaDepartment of Lymphoma & Hematology, Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, ChinaSchool of Public Health, North China University of Science and Technology, Tangshan, People`s Republic of ChinaSchool of Public Health, North China University of Science and Technology, Tangshan, People`s Republic of ChinaSchool of Public Health, North China University of Science and Technology, Tangshan, People`s Republic of ChinaSchool of Public Health, North China University of Science and Technology, Tangshan, People`s Republic of ChinaObjectives This study aimed to assess the association between longitudinal change in non-high-density lipoprotein cholesterol (non-HDL-C) and subsequent cardiovascular disease (CVD) risk.Design A retrospective study.Setting Data were obtained from the Kailuan Study, a dynamic cohort study initiated in 2006 in Tangshan, China.Participants The current study included 41 085 participants (mean age 53.9±11.6 years) free of CVD events in or before 2012. The non-HDL-C trajectory was developed according to the repeated measurement during 2006–2012 surveys to predict the CVD risk from 2012 to 2020.Primary outcome measures CVD events included myocardial infarction and stroke.Results 3 discrete non-HDL-C trajectories were identified: low-increasing (n=20 038), moderate-increasing (n=17 987) and high-increasing (n=3060). During 8 years of follow-up, 1797 CVD events were documented. Relative to the low-increasing pattern, adjusted HRs were 1.25 (95% CI: 1.13 to 1.38) for the moderate-increasing pattern and 1.46 (95% CI: 1.24 to 1.71) for the high-increasing pattern after adjustment for potential confounders such as age, sex, education background, smoking status, drinking status, physical activity, body mass index, low-density lipoprotein cholesterol, hypertension, diabetes and lipid-lowering medications.Conclusions Changes in non-HDL-C were significantly associated with subsequent risk of CVD events, and participants with a high-increasing pattern had a higher CVD risk. Long-term monitoring of non-HDL-C could be useful to improve the prediction of CVD risk.Trial registration number ChiCTR-TNC-1100148.https://bmjopen.bmj.com/content/13/4/e069807.full |
| spellingShingle | Yun Li Hui Zhou Qing Yue Xiaoxu Ma Xiong Ding Zhe Shu Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study BMJ Open |
| title | Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study |
| title_full | Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study |
| title_fullStr | Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study |
| title_full_unstemmed | Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study |
| title_short | Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study |
| title_sort | association of trajectories of non high density lipoprotein cholesterol concentration with risk of cardiovascular disease the kailuan study |
| url | https://bmjopen.bmj.com/content/13/4/e069807.full |
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