Effects of Internal Exposure of Radioactive <sup>56</sup>MnO<sub>2</sub> Particles on the Lung in C57BL Mice
The investigation of the radiation effects of the atomic bombing in Hiroshima and Nagasaki has revealed concerns about the impact of the residual radioactive dust produced in the soil. Manganese-56 is one of the major radioisotopes produced by neutrons from the bomb; hence, we previously examined th...
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MDPI AG
2023-04-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/4/209 |
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| author | Zhaslan Abishev Bakhyt Ruslanova Saulesh Apbassova Nailya Chaizhunussova Dariya Shabdarbayeva Almas Azimkhanov Kassym Zhumadilov Valeriy Stepanenko Sergey Ivanov Peter Shegay Masaharu Hoshi Nariaki Fujimoto |
| author_facet | Zhaslan Abishev Bakhyt Ruslanova Saulesh Apbassova Nailya Chaizhunussova Dariya Shabdarbayeva Almas Azimkhanov Kassym Zhumadilov Valeriy Stepanenko Sergey Ivanov Peter Shegay Masaharu Hoshi Nariaki Fujimoto |
| author_sort | Zhaslan Abishev |
| collection | DOAJ |
| description | The investigation of the radiation effects of the atomic bombing in Hiroshima and Nagasaki has revealed concerns about the impact of the residual radioactive dust produced in the soil. Manganese-56 is one of the major radioisotopes produced by neutrons from the bomb; hence, we previously examined the biological effects of manganese dioxide-56 (<sup>56</sup>MnO<sub>2</sub>) in Wistar rats, in which significant changes were found in the lung. In the present study, ten-week-old male C57BL mice were exposed to three doses of radioactive <sup>56</sup>MnO<sub>2</sub>, stable MnO<sub>2</sub> particles, or external γ-rays (2 Gy) to further examine the effects of <sup>56</sup>MnO<sub>2</sub> in a different species. The estimated absorbed radiation doses from <sup>56</sup>MnO<sub>2</sub> were 26, 96, and 250 mGy in the lung. The animals were examined at 3, 14, and 70 days post exposure. Histologically, no exposure-related changes were found in the lungs of any group. However, pulmonary mRNA expression of aquaporin 1, which is a useful marker for lung pathophysiology, was significantly elevated at 14 and 70 days, although no such changes were found in the mice exposed to external γ-rays (2 Gy). These data indicated that the inhalation exposure to <sup>56</sup>MnO<sub>2</sub> particles, with <250 mGy of organ doses, produced significant biological responses in the lung. |
| first_indexed | 2024-03-11T05:07:49Z |
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| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T05:07:49Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj.art-34ee1ffefa6442fa92ffe4ef5c5f08312023-11-17T18:47:48ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-04-014543208321810.3390/cimb45040209Effects of Internal Exposure of Radioactive <sup>56</sup>MnO<sub>2</sub> Particles on the Lung in C57BL MiceZhaslan Abishev0Bakhyt Ruslanova1Saulesh Apbassova2Nailya Chaizhunussova3Dariya Shabdarbayeva4Almas Azimkhanov5Kassym Zhumadilov6Valeriy Stepanenko7Sergey Ivanov8Peter Shegay9Masaharu Hoshi10Nariaki Fujimoto11Department of Pathological Anatomy and Forensic Medicine, Semey Medical University, Semey 071400, KazakhstanDepartment of Pathological Anatomy and Forensic Medicine, Semey Medical University, Semey 071400, KazakhstanDepartment of Pathological Anatomy and Forensic Medicine, Semey Medical University, Semey 071400, KazakhstanDepartment of Public Health, Semey Medical University, Semey 071400, KazakhstanDepartment of Pathological Anatomy and Forensic Medicine, Semey Medical University, Semey 071400, KazakhstanNational Nuclear Center of the Republic of Kazakhstan, Kurchatov 071100, KazakhstanDepartment of Nuclear Physics, L.N. Gumilyov Eurasian National University, Astana 010000, KazakhstanA. Tsyb Medical Radiological Research Center—National Medical Research Center of Radiology, Ministry of Health of Russian Federation, 249031 Obninsk, RussiaA. Tsyb Medical Radiological Research Center—National Medical Research Center of Radiology, Ministry of Health of Russian Federation, 249031 Obninsk, RussiaNational Medical Research Center of Radiology, Ministry of Health of the Russian Federation, 249031 Obninsk, RussiaThe Center for Peace, Hiroshima University, Hiroshima 730-0053, JapanResearch Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-0037, JapanThe investigation of the radiation effects of the atomic bombing in Hiroshima and Nagasaki has revealed concerns about the impact of the residual radioactive dust produced in the soil. Manganese-56 is one of the major radioisotopes produced by neutrons from the bomb; hence, we previously examined the biological effects of manganese dioxide-56 (<sup>56</sup>MnO<sub>2</sub>) in Wistar rats, in which significant changes were found in the lung. In the present study, ten-week-old male C57BL mice were exposed to three doses of radioactive <sup>56</sup>MnO<sub>2</sub>, stable MnO<sub>2</sub> particles, or external γ-rays (2 Gy) to further examine the effects of <sup>56</sup>MnO<sub>2</sub> in a different species. The estimated absorbed radiation doses from <sup>56</sup>MnO<sub>2</sub> were 26, 96, and 250 mGy in the lung. The animals were examined at 3, 14, and 70 days post exposure. Histologically, no exposure-related changes were found in the lungs of any group. However, pulmonary mRNA expression of aquaporin 1, which is a useful marker for lung pathophysiology, was significantly elevated at 14 and 70 days, although no such changes were found in the mice exposed to external γ-rays (2 Gy). These data indicated that the inhalation exposure to <sup>56</sup>MnO<sub>2</sub> particles, with <250 mGy of organ doses, produced significant biological responses in the lung.https://www.mdpi.com/1467-3045/45/4/209residual radiationinternal radiation exposureradiation injurylung |
| spellingShingle | Zhaslan Abishev Bakhyt Ruslanova Saulesh Apbassova Nailya Chaizhunussova Dariya Shabdarbayeva Almas Azimkhanov Kassym Zhumadilov Valeriy Stepanenko Sergey Ivanov Peter Shegay Masaharu Hoshi Nariaki Fujimoto Effects of Internal Exposure of Radioactive <sup>56</sup>MnO<sub>2</sub> Particles on the Lung in C57BL Mice Current Issues in Molecular Biology residual radiation internal radiation exposure radiation injury lung |
| title | Effects of Internal Exposure of Radioactive <sup>56</sup>MnO<sub>2</sub> Particles on the Lung in C57BL Mice |
| title_full | Effects of Internal Exposure of Radioactive <sup>56</sup>MnO<sub>2</sub> Particles on the Lung in C57BL Mice |
| title_fullStr | Effects of Internal Exposure of Radioactive <sup>56</sup>MnO<sub>2</sub> Particles on the Lung in C57BL Mice |
| title_full_unstemmed | Effects of Internal Exposure of Radioactive <sup>56</sup>MnO<sub>2</sub> Particles on the Lung in C57BL Mice |
| title_short | Effects of Internal Exposure of Radioactive <sup>56</sup>MnO<sub>2</sub> Particles on the Lung in C57BL Mice |
| title_sort | effects of internal exposure of radioactive sup 56 sup mno sub 2 sub particles on the lung in c57bl mice |
| topic | residual radiation internal radiation exposure radiation injury lung |
| url | https://www.mdpi.com/1467-3045/45/4/209 |
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