Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19
Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1148446/full |
| _version_ | 1797893690612514816 |
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| author | Ping-Yuan Lin Yi-Wei Chung Yi-Wei Chung Yi-Wei Chung Yi-Wei Chung Er-Yuan Chuang Yen-Chieh Wang Min-Chih Lai Yen-Chin Hsu Chun-Che Lin Yu-Cheng Hsiao Yu-Cheng Hsiao Yu-Cheng Hsiao Yu-Cheng Hsiao |
| author_facet | Ping-Yuan Lin Yi-Wei Chung Yi-Wei Chung Yi-Wei Chung Yi-Wei Chung Er-Yuan Chuang Yen-Chieh Wang Min-Chih Lai Yen-Chin Hsu Chun-Che Lin Yu-Cheng Hsiao Yu-Cheng Hsiao Yu-Cheng Hsiao Yu-Cheng Hsiao |
| author_sort | Ping-Yuan Lin |
| collection | DOAJ |
| description | Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases. |
| first_indexed | 2024-04-10T06:56:53Z |
| format | Article |
| id | doaj.art-34f3fe671b2341e2a33b86694b1cfe32 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T06:56:53Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-34f3fe671b2341e2a33b86694b1cfe322023-02-28T06:45:15ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-02-011110.3389/fbioe.2023.11484461148446Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19Ping-Yuan Lin0Yi-Wei Chung1Yi-Wei Chung2Yi-Wei Chung3Yi-Wei Chung4Er-Yuan Chuang5Yen-Chieh Wang6Min-Chih Lai7Yen-Chin Hsu8Chun-Che Lin9Yu-Cheng Hsiao10Yu-Cheng Hsiao11Yu-Cheng Hsiao12Yu-Cheng Hsiao13Graduate Institute of Biomedical Opto mechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei, TaiwanCardiovascular Research Center, Taipei Medical University Hospital, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, TaiwanSchool of Biomedical Engineering, Taipei Medical University, Taipei, TaiwanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei, TaiwanSchool of Biomedical Engineering, Taipei Medical University, Taipei, TaiwanInstitute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei, TaiwanGraduate Institute of Biomedical Opto mechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei, TaiwanSchool of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan0Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan1Stanford Byers Center for Bio Design, Stanford, CA, United StatesRapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1148446/fullCOVID-19cholesteric liquid crystalbiosensordiagnosisspike protein |
| spellingShingle | Ping-Yuan Lin Yi-Wei Chung Yi-Wei Chung Yi-Wei Chung Yi-Wei Chung Er-Yuan Chuang Yen-Chieh Wang Min-Chih Lai Yen-Chin Hsu Chun-Che Lin Yu-Cheng Hsiao Yu-Cheng Hsiao Yu-Cheng Hsiao Yu-Cheng Hsiao Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19 Frontiers in Bioengineering and Biotechnology COVID-19 cholesteric liquid crystal biosensor diagnosis spike protein |
| title | Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19 |
| title_full | Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19 |
| title_fullStr | Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19 |
| title_full_unstemmed | Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19 |
| title_short | Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19 |
| title_sort | cholesteric liquid crystal biosensor platform with image analysis for rapid detection of covid 19 |
| topic | COVID-19 cholesteric liquid crystal biosensor diagnosis spike protein |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1148446/full |
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