Treatment Trials in Disorders of Consciousness: Challenges and Future Directions
The evidence base supporting treatment interventions for patients with disorders of consciousness is limited, and rigorous treatment trials are needed to guide future management of this complex patient population. There are many potential study designs that can be employed to develop this evidence,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/12/5/569 |
| _version_ | 1797501160459862016 |
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| author | Michael H. Marino John Whyte |
| author_facet | Michael H. Marino John Whyte |
| author_sort | Michael H. Marino |
| collection | DOAJ |
| description | The evidence base supporting treatment interventions for patients with disorders of consciousness is limited, and rigorous treatment trials are needed to guide future management of this complex patient population. There are many potential study designs that can be employed to develop this evidence, but the process of selecting the optimal study design is challenging. This article reviews common obstacles that impede research progress in this population and a range of study designs that may be employed. In addition, we consider how the particular practical and scientific obstacles may drive selection of the optimal design and, in particular, how the optimal design changes as treatment research proceeds along the translational continuum from mechanistic discovery to real-world clinical impact. |
| first_indexed | 2024-03-10T03:14:22Z |
| format | Article |
| id | doaj.art-34f46391a9f146178bd86146dba683a7 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:22Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-34f46391a9f146178bd86146dba683a72023-11-23T10:17:15ZengMDPI AGBrain Sciences2076-34252022-04-0112556910.3390/brainsci12050569Treatment Trials in Disorders of Consciousness: Challenges and Future DirectionsMichael H. Marino0John Whyte1MossRehab Hospital, Elkins Park, PA 19027, USAMossRehab Hospital, Elkins Park, PA 19027, USAThe evidence base supporting treatment interventions for patients with disorders of consciousness is limited, and rigorous treatment trials are needed to guide future management of this complex patient population. There are many potential study designs that can be employed to develop this evidence, but the process of selecting the optimal study design is challenging. This article reviews common obstacles that impede research progress in this population and a range of study designs that may be employed. In addition, we consider how the particular practical and scientific obstacles may drive selection of the optimal design and, in particular, how the optimal design changes as treatment research proceeds along the translational continuum from mechanistic discovery to real-world clinical impact.https://www.mdpi.com/2076-3425/12/5/569disorders of consciousnessclinical trials |
| spellingShingle | Michael H. Marino John Whyte Treatment Trials in Disorders of Consciousness: Challenges and Future Directions Brain Sciences disorders of consciousness clinical trials |
| title | Treatment Trials in Disorders of Consciousness: Challenges and Future Directions |
| title_full | Treatment Trials in Disorders of Consciousness: Challenges and Future Directions |
| title_fullStr | Treatment Trials in Disorders of Consciousness: Challenges and Future Directions |
| title_full_unstemmed | Treatment Trials in Disorders of Consciousness: Challenges and Future Directions |
| title_short | Treatment Trials in Disorders of Consciousness: Challenges and Future Directions |
| title_sort | treatment trials in disorders of consciousness challenges and future directions |
| topic | disorders of consciousness clinical trials |
| url | https://www.mdpi.com/2076-3425/12/5/569 |
| work_keys_str_mv | AT michaelhmarino treatmenttrialsindisordersofconsciousnesschallengesandfuturedirections AT johnwhyte treatmenttrialsindisordersofconsciousnesschallengesandfuturedirections |