The role of cofilin in age-related neuroinflammation
Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active “pro-inflammatory” state, causing chronic low-grade neuroinflammation. Despite the fact that the role of neuroinflammation during aging has been extensively studied in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=8;spage=1451;epage=1459;aulast=Alsegiani |
| _version_ | 1818410041621872640 |
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| author | Amsha S Alsegiani Zahoor A Shah |
| author_facet | Amsha S Alsegiani Zahoor A Shah |
| author_sort | Amsha S Alsegiani |
| collection | DOAJ |
| description | Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active “pro-inflammatory” state, causing chronic low-grade neuroinflammation. Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years, the underlying causes remain unclear. The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment. This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly. In this review, we have summarized the morphological and cellular changes in the aging brain, the effects of age-related neuroinflammation, and the potential role of cofilin-1 during neuroinflammation. We also discuss other factors contributing to brain aging and neuroinflammation. |
| first_indexed | 2024-12-14T10:09:13Z |
| format | Article |
| id | doaj.art-34f508b4607a4fe3bdfa411ddf13bd63 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-14T10:09:13Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-34f508b4607a4fe3bdfa411ddf13bd632022-12-21T23:07:03ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742020-01-011581451145910.4103/1673-5374.274330The role of cofilin in age-related neuroinflammationAmsha S AlsegianiZahoor A ShahAging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active “pro-inflammatory” state, causing chronic low-grade neuroinflammation. Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years, the underlying causes remain unclear. The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment. This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly. In this review, we have summarized the morphological and cellular changes in the aging brain, the effects of age-related neuroinflammation, and the potential role of cofilin-1 during neuroinflammation. We also discuss other factors contributing to brain aging and neuroinflammation.http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=8;spage=1451;epage=1459;aulast=Alsegianiaging; astrocyte-activation; cofilin; cofilin inhibitor; cofilin/actin rods; inflammaging; microglial activation; neurogenesis; neuroinflammation |
| spellingShingle | Amsha S Alsegiani Zahoor A Shah The role of cofilin in age-related neuroinflammation Neural Regeneration Research aging; astrocyte-activation; cofilin; cofilin inhibitor; cofilin/actin rods; inflammaging; microglial activation; neurogenesis; neuroinflammation |
| title | The role of cofilin in age-related neuroinflammation |
| title_full | The role of cofilin in age-related neuroinflammation |
| title_fullStr | The role of cofilin in age-related neuroinflammation |
| title_full_unstemmed | The role of cofilin in age-related neuroinflammation |
| title_short | The role of cofilin in age-related neuroinflammation |
| title_sort | role of cofilin in age related neuroinflammation |
| topic | aging; astrocyte-activation; cofilin; cofilin inhibitor; cofilin/actin rods; inflammaging; microglial activation; neurogenesis; neuroinflammation |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=8;spage=1451;epage=1459;aulast=Alsegiani |
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