AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
Non-small cell lung cancer with EGFR mutations are known to develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors show AURKB activation to be associated with resistance in EGFR mutant lung cancer cells, and that AURKB is a therapeutic target in resistant tumours that lack the p.T7...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09734-5 |
| _version_ | 1818996749171163136 |
|---|---|
| author | Jordi Bertran-Alamillo Valérie Cattan Marie Schoumacher Jordi Codony-Servat Ana Giménez-Capitán Frédérique Cantero Mike Burbridge Sonia Rodríguez Cristina Teixidó Ruth Roman Josep Castellví Silvia García-Román Carles Codony-Servat Santiago Viteri Andrés-Felipe Cardona Niki Karachaliou Rafael Rosell Miguel-Angel Molina-Vila |
| author_facet | Jordi Bertran-Alamillo Valérie Cattan Marie Schoumacher Jordi Codony-Servat Ana Giménez-Capitán Frédérique Cantero Mike Burbridge Sonia Rodríguez Cristina Teixidó Ruth Roman Josep Castellví Silvia García-Román Carles Codony-Servat Santiago Viteri Andrés-Felipe Cardona Niki Karachaliou Rafael Rosell Miguel-Angel Molina-Vila |
| author_sort | Jordi Bertran-Alamillo |
| collection | DOAJ |
| description | Non-small cell lung cancer with EGFR mutations are known to develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors show AURKB activation to be associated with resistance in EGFR mutant lung cancer cells, and that AURKB is a therapeutic target in resistant tumours that lack the p.T790M or other acquired mutations. |
| first_indexed | 2024-12-20T21:34:41Z |
| format | Article |
| id | doaj.art-34f8c0286b2b4c818818bdd02b7b3019 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:34:41Z |
| publishDate | 2019-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-34f8c0286b2b4c818818bdd02b7b30192022-12-21T19:25:59ZengNature PortfolioNature Communications2041-17232019-04-0110111410.1038/s41467-019-09734-5AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapyJordi Bertran-Alamillo0Valérie Cattan1Marie Schoumacher2Jordi Codony-Servat3Ana Giménez-Capitán4Frédérique Cantero5Mike Burbridge6Sonia Rodríguez7Cristina Teixidó8Ruth Roman9Josep Castellví10Silvia García-Román11Carles Codony-Servat12Santiago Viteri13Andrés-Felipe Cardona14Niki Karachaliou15Rafael Rosell16Miguel-Angel Molina-Vila17Laboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalInstitut de Recherches Internationales ServierInstitut de Recherches Internationales ServierLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalInstitut de Recherches Internationales ServierInstitut de Recherches Internationales ServierLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalInstituto Oncológico Dr. Rosell, Quiron-Dexeus University HospitalClinical and Translational Oncology Group, Institute of Oncology, Fundacion Santa Fe de BogotáInstituto Oncológico Dr. Rosell, Quiron-Dexeus University HospitalLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalLaboratory of Oncology, Pangaea Oncology, Quiron Dexeus University HospitalNon-small cell lung cancer with EGFR mutations are known to develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors show AURKB activation to be associated with resistance in EGFR mutant lung cancer cells, and that AURKB is a therapeutic target in resistant tumours that lack the p.T790M or other acquired mutations.https://doi.org/10.1038/s41467-019-09734-5 |
| spellingShingle | Jordi Bertran-Alamillo Valérie Cattan Marie Schoumacher Jordi Codony-Servat Ana Giménez-Capitán Frédérique Cantero Mike Burbridge Sonia Rodríguez Cristina Teixidó Ruth Roman Josep Castellví Silvia García-Román Carles Codony-Servat Santiago Viteri Andrés-Felipe Cardona Niki Karachaliou Rafael Rosell Miguel-Angel Molina-Vila AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy Nature Communications |
| title | AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy |
| title_full | AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy |
| title_fullStr | AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy |
| title_full_unstemmed | AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy |
| title_short | AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy |
| title_sort | aurkb as a target in non small cell lung cancer with acquired resistance to anti egfr therapy |
| url | https://doi.org/10.1038/s41467-019-09734-5 |
| work_keys_str_mv | AT jordibertranalamillo aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT valeriecattan aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT marieschoumacher aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT jordicodonyservat aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT anagimenezcapitan aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT frederiquecantero aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT mikeburbridge aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT soniarodriguez aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT cristinateixido aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT ruthroman aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT josepcastellvi aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT silviagarciaroman aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT carlescodonyservat aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT santiagoviteri aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT andresfelipecardona aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT nikikarachaliou aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT rafaelrosell aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy AT miguelangelmolinavila aurkbasatargetinnonsmallcelllungcancerwithacquiredresistancetoantiegfrtherapy |