Impact and Treatment of Sarcopenia in Patients Undergoing Radiotherapy: A Multidisciplinary, AMSTAR-2 Compliant Review of Systematic Reviews and Metanalyses
BackgroundSarcopenia (SP) is defined as the quantitative and functional impairment of skeletal muscles. SP is commonly related to older age and is frequent in patients with cancer. To provide an overview of SP in patients treated with radiotherapy (RT) and to evaluate the current evidence, we analyz...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.887156/full |
| _version_ | 1828811227957035008 |
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| author | Federica Medici Alberto Bazzocchi Milly Buwenge Alice Zamagni Gabriella Macchia Francesco Deodato Savino Cilla Pierandrea De Iaco Pierandrea De Iaco Anna Myriam Perrone Anna Myriam Perrone Lidia Strigari Stefania Rizzo Alessio G. Morganti Alessio G. Morganti |
| author_facet | Federica Medici Alberto Bazzocchi Milly Buwenge Alice Zamagni Gabriella Macchia Francesco Deodato Savino Cilla Pierandrea De Iaco Pierandrea De Iaco Anna Myriam Perrone Anna Myriam Perrone Lidia Strigari Stefania Rizzo Alessio G. Morganti Alessio G. Morganti |
| author_sort | Federica Medici |
| collection | DOAJ |
| description | BackgroundSarcopenia (SP) is defined as the quantitative and functional impairment of skeletal muscles. SP is commonly related to older age and is frequent in patients with cancer. To provide an overview of SP in patients treated with radiotherapy (RT) and to evaluate the current evidence, we analyzed the available systematic reviews and meta-analyses.MethodsReviews were identified using PubMed, Scopus, and Cochrane library databases, without date restriction. Only systematic reviews and meta-analyses on the prognostic impact of SP and on any treatments aimed at reducing SP effect, in patients undergoing RT, were included in this review. The analyses not separately reporting the results in patients treated with RT were excluded. The quality assessment was performed using AMSTAR-2 (A MeaSurement Tool to Assess systematic Reviews).ResultsFrom the 84 papers identified, five reviews met the inclusion criteria with four reports mainly including non-randomized trials. Three reviews on the effect of SP showed a significantly negative impact on overall survival in patients undergoing RT and/or chemoradiation for H&N cancers (HR: 1.63-2.07). Two reviews on interventional studies showed the possibility of 1) improving physical functions through nutritional and physical interventions and 2) avoiding muscle wasting by means of sufficient protein intake. The quality assessment of the included review showed that two and three analyses are classifiable as having low and moderate overall confidence rating, respectively.ConclusionsThe analyzed reviews uniformly confirmed the negative impact of SP in patients with H&N tumors undergoing RT and the possibility of improving muscle mass and function through nutritional and physical interventions. These results justify further research on this topic based on a more uniform SP definition and on a complete evaluation of the potentially confounding parameters. |
| first_indexed | 2024-12-12T09:24:42Z |
| format | Article |
| id | doaj.art-34f99b8161e34e60a8dc6eaa1ac6c75a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T09:24:42Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-34f99b8161e34e60a8dc6eaa1ac6c75a2022-12-22T00:29:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.887156887156Impact and Treatment of Sarcopenia in Patients Undergoing Radiotherapy: A Multidisciplinary, AMSTAR-2 Compliant Review of Systematic Reviews and MetanalysesFederica Medici0Alberto Bazzocchi1Milly Buwenge2Alice Zamagni3Gabriella Macchia4Francesco Deodato5Savino Cilla6Pierandrea De Iaco7Pierandrea De Iaco8Anna Myriam Perrone9Anna Myriam Perrone10Lidia Strigari11Stefania Rizzo12Alessio G. Morganti13Alessio G. Morganti14Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, Bologna, ItalyDiagnostic and Interventional Radiology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, Bologna, ItalyRadiation Oncology Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, ItalyRadiation Oncology Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, ItalyMedical Physics Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, ItalyDivision of Oncologic Gynecology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyCentro di Studio e Ricerca delle Neoplasie Ginecologiche (CSR), University of Bologna, Bologna, ItalyDivision of Oncologic Gynecology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyCentro di Studio e Ricerca delle Neoplasie Ginecologiche (CSR), University of Bologna, Bologna, ItalyMedical Physics Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyService of Radiology, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Lugano, SwitzerlandDepartment of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, Bologna, ItalyRadiation Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyBackgroundSarcopenia (SP) is defined as the quantitative and functional impairment of skeletal muscles. SP is commonly related to older age and is frequent in patients with cancer. To provide an overview of SP in patients treated with radiotherapy (RT) and to evaluate the current evidence, we analyzed the available systematic reviews and meta-analyses.MethodsReviews were identified using PubMed, Scopus, and Cochrane library databases, without date restriction. Only systematic reviews and meta-analyses on the prognostic impact of SP and on any treatments aimed at reducing SP effect, in patients undergoing RT, were included in this review. The analyses not separately reporting the results in patients treated with RT were excluded. The quality assessment was performed using AMSTAR-2 (A MeaSurement Tool to Assess systematic Reviews).ResultsFrom the 84 papers identified, five reviews met the inclusion criteria with four reports mainly including non-randomized trials. Three reviews on the effect of SP showed a significantly negative impact on overall survival in patients undergoing RT and/or chemoradiation for H&N cancers (HR: 1.63-2.07). Two reviews on interventional studies showed the possibility of 1) improving physical functions through nutritional and physical interventions and 2) avoiding muscle wasting by means of sufficient protein intake. The quality assessment of the included review showed that two and three analyses are classifiable as having low and moderate overall confidence rating, respectively.ConclusionsThe analyzed reviews uniformly confirmed the negative impact of SP in patients with H&N tumors undergoing RT and the possibility of improving muscle mass and function through nutritional and physical interventions. These results justify further research on this topic based on a more uniform SP definition and on a complete evaluation of the potentially confounding parameters.https://www.frontiersin.org/articles/10.3389/fonc.2022.887156/fullliterature reviewradiotherapysarcopeniaprognostic factorsAMSTAR-2 |
| spellingShingle | Federica Medici Alberto Bazzocchi Milly Buwenge Alice Zamagni Gabriella Macchia Francesco Deodato Savino Cilla Pierandrea De Iaco Pierandrea De Iaco Anna Myriam Perrone Anna Myriam Perrone Lidia Strigari Stefania Rizzo Alessio G. Morganti Alessio G. Morganti Impact and Treatment of Sarcopenia in Patients Undergoing Radiotherapy: A Multidisciplinary, AMSTAR-2 Compliant Review of Systematic Reviews and Metanalyses Frontiers in Oncology literature review radiotherapy sarcopenia prognostic factors AMSTAR-2 |
| title | Impact and Treatment of Sarcopenia in Patients Undergoing Radiotherapy: A Multidisciplinary, AMSTAR-2 Compliant Review of Systematic Reviews and Metanalyses |
| title_full | Impact and Treatment of Sarcopenia in Patients Undergoing Radiotherapy: A Multidisciplinary, AMSTAR-2 Compliant Review of Systematic Reviews and Metanalyses |
| title_fullStr | Impact and Treatment of Sarcopenia in Patients Undergoing Radiotherapy: A Multidisciplinary, AMSTAR-2 Compliant Review of Systematic Reviews and Metanalyses |
| title_full_unstemmed | Impact and Treatment of Sarcopenia in Patients Undergoing Radiotherapy: A Multidisciplinary, AMSTAR-2 Compliant Review of Systematic Reviews and Metanalyses |
| title_short | Impact and Treatment of Sarcopenia in Patients Undergoing Radiotherapy: A Multidisciplinary, AMSTAR-2 Compliant Review of Systematic Reviews and Metanalyses |
| title_sort | impact and treatment of sarcopenia in patients undergoing radiotherapy a multidisciplinary amstar 2 compliant review of systematic reviews and metanalyses |
| topic | literature review radiotherapy sarcopenia prognostic factors AMSTAR-2 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.887156/full |
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