Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study
BackgroundSome studies suggest sedentary behavior is a risk factor for musculoskeletal disorders. This study aimed to investigate the potential causal association between leisure sedentary behavior (LSB) (including television (TV) viewing, computer use, and driving) and the incidence of sciatica, in...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1284594/full |
| _version_ | 1827376276492517376 |
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| author | Youjia Qiu Xingzhou Wei Yuchen Tao Bingyi Song Menghan Wang Ziqian Yin Minjia Xie Aojie Duan Zhouqing Chen Zhong Wang |
| author_facet | Youjia Qiu Xingzhou Wei Yuchen Tao Bingyi Song Menghan Wang Ziqian Yin Minjia Xie Aojie Duan Zhouqing Chen Zhong Wang |
| author_sort | Youjia Qiu |
| collection | DOAJ |
| description | BackgroundSome studies suggest sedentary behavior is a risk factor for musculoskeletal disorders. This study aimed to investigate the potential causal association between leisure sedentary behavior (LSB) (including television (TV) viewing, computer use, and driving) and the incidence of sciatica, intervertebral disk degeneration (IVDD), low back pain (LBP), and cervical spondylosis (CS).MethodsWe obtained the data of LSB, CS, IVDD, LBP, sciatica and proposed mediators from the gene-wide association studies (GWAS). The causal effects were examined by Inverse Variance Weighted (IVW) test, MR-Egger, weighted median, weighted mode and simple mode. And sensitivity analysis was performed using MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO) and MR-Egger intercept test. Multivariable MR (MVMR) was conducted to investigate the independent factor of other LSB; while two-step MR analysis was used to explore the potential mediators including Body mass index (BMI), smoking initiation, type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), schizophrenia, bipolar disorder between the causal association of LSB and these diseases based on previous studies.ResultsGenetically associated TV viewing was positively associated with the risk of CS (OR = 1.61, 95%CI = 1.25 to 2.07, p = 0.002), IVDD (OR = 2.10, 95%CI = 1.77 to 2.48, p = 3.79 × 10−18), LBP (OR = 1.84, 95%CI = 1.53 to 2.21, p = 1.04 × 10−10) and sciatica (OR = 1.82, 95% CI = 1.45 to 2.27, p = 1.42 × 10−7). While computer use was associated with a reduced risk of IVDD (OR = 0.66, 95%CI = 0.55 to 0.79, p = 8.06 × 10−6), LBP (OR = 0.49, 95%CI = 0.40 to 0.59, p = 2.68 × 10−13) and sciatica (OR = 0.58, 95%CI = 0.46 to 0.75, p = 1.98 × 10−5). Sensitivity analysis validated the robustness of MR outcomes. MVMR analysis showed that the causal effect of TV viewing on IVDD (OR = 1.59, 95%CI = 1.13 to 2.25, p = 0.008), LBP (OR = 2.15, 95%CI = 1.50 to 3.08, p = 3.38 × 10−5), and sciatica (OR = 1.61, 95%CI = 1.03 to 2.52, p = 0.037) was independent of other LSB. Furthermore, two-step MR analysis indicated that BMI, smoking initiation, T2DM may mediate the causal effect of TV viewing on these diseases.ConclusionThis study provides empirical evidence supporting a positive causal association between TV viewing and sciatica, IVDD and LBP, which were potentially mediated by BMI, smoking initiation and T2DM. |
| first_indexed | 2024-03-08T12:07:30Z |
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| language | English |
| last_indexed | 2024-03-08T12:07:30Z |
| publishDate | 2024-01-01 |
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| series | Frontiers in Public Health |
| spelling | doaj.art-34fa2638a8794a799ee034b682eda7622024-01-23T04:25:51ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-01-011210.3389/fpubh.2024.12845941284594Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization studyYoujia Qiu0Xingzhou Wei1Yuchen Tao2Bingyi Song3Menghan Wang4Ziqian Yin5Minjia Xie6Aojie Duan7Zhouqing Chen8Zhong Wang9Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaSuzhou Medical School of Soochow University, Suzhou, Jiangsu, ChinaSuzhou Medical School of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaSuzhou Medical School of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaBackgroundSome studies suggest sedentary behavior is a risk factor for musculoskeletal disorders. This study aimed to investigate the potential causal association between leisure sedentary behavior (LSB) (including television (TV) viewing, computer use, and driving) and the incidence of sciatica, intervertebral disk degeneration (IVDD), low back pain (LBP), and cervical spondylosis (CS).MethodsWe obtained the data of LSB, CS, IVDD, LBP, sciatica and proposed mediators from the gene-wide association studies (GWAS). The causal effects were examined by Inverse Variance Weighted (IVW) test, MR-Egger, weighted median, weighted mode and simple mode. And sensitivity analysis was performed using MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO) and MR-Egger intercept test. Multivariable MR (MVMR) was conducted to investigate the independent factor of other LSB; while two-step MR analysis was used to explore the potential mediators including Body mass index (BMI), smoking initiation, type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), schizophrenia, bipolar disorder between the causal association of LSB and these diseases based on previous studies.ResultsGenetically associated TV viewing was positively associated with the risk of CS (OR = 1.61, 95%CI = 1.25 to 2.07, p = 0.002), IVDD (OR = 2.10, 95%CI = 1.77 to 2.48, p = 3.79 × 10−18), LBP (OR = 1.84, 95%CI = 1.53 to 2.21, p = 1.04 × 10−10) and sciatica (OR = 1.82, 95% CI = 1.45 to 2.27, p = 1.42 × 10−7). While computer use was associated with a reduced risk of IVDD (OR = 0.66, 95%CI = 0.55 to 0.79, p = 8.06 × 10−6), LBP (OR = 0.49, 95%CI = 0.40 to 0.59, p = 2.68 × 10−13) and sciatica (OR = 0.58, 95%CI = 0.46 to 0.75, p = 1.98 × 10−5). Sensitivity analysis validated the robustness of MR outcomes. MVMR analysis showed that the causal effect of TV viewing on IVDD (OR = 1.59, 95%CI = 1.13 to 2.25, p = 0.008), LBP (OR = 2.15, 95%CI = 1.50 to 3.08, p = 3.38 × 10−5), and sciatica (OR = 1.61, 95%CI = 1.03 to 2.52, p = 0.037) was independent of other LSB. Furthermore, two-step MR analysis indicated that BMI, smoking initiation, T2DM may mediate the causal effect of TV viewing on these diseases.ConclusionThis study provides empirical evidence supporting a positive causal association between TV viewing and sciatica, IVDD and LBP, which were potentially mediated by BMI, smoking initiation and T2DM.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1284594/fullleisure sedentary behaviorsciaticacervical spondylosisintervertebral disk disorderslow back painMendelian randomization |
| spellingShingle | Youjia Qiu Xingzhou Wei Yuchen Tao Bingyi Song Menghan Wang Ziqian Yin Minjia Xie Aojie Duan Zhouqing Chen Zhong Wang Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study Frontiers in Public Health leisure sedentary behavior sciatica cervical spondylosis intervertebral disk disorders low back pain Mendelian randomization |
| title | Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study |
| title_full | Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study |
| title_fullStr | Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study |
| title_full_unstemmed | Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study |
| title_short | Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study |
| title_sort | causal association of leisure sedentary behavior and cervical spondylosis sciatica intervertebral disk disorders and low back pain a mendelian randomization study |
| topic | leisure sedentary behavior sciatica cervical spondylosis intervertebral disk disorders low back pain Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1284594/full |
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