Hyperthermia based individual in situ recombinant vaccine enhances lymph nodes drainage for de novo antitumor immunity

Hyperthermia based individual in situ recombinant vaccine enhances lymph nodes drainage for de novo antitumor immunity

The continuing challenges that limit effectiveness of tumor therapeutic vaccines were high heterogeneity of tumor immunogenicity, low bioactivity of antigens, as well as insufficient lymph nodes (LNs) drainage of antigens and adjuvants. Transportation of in situ neoantigens and adjuvants to LNs may...

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Bibliographic Details
Main Authors: Cuixia Zheng, Xinxin Liu, Yueyue Kong, Lei Zhang, Qingling Song, Hongjuan Zhao, Lu Han, Jiannan Jiao, Qianhua Feng, Lei Wang
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Au nanocages
Simvastatin
Photothermal therapy
Tumor-derived protein antigens
Recombinant vaccine
Tumor targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522000831

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http://www.sciencedirect.com/science/article/pii/S2211383522000831

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