Chronic Oleoylethanolamide Treatment Decreases Hepatic Triacylglycerol Level in Rat Liver by a PPARγ/SREBP-Mediated Suppression of Fatty Acid and Triacylglycerol Synthesis

Chronic Oleoylethanolamide Treatment Decreases Hepatic Triacylglycerol Level in Rat Liver by a PPARγ/SREBP-Mediated Suppression of Fatty Acid and Triacylglycerol Synthesis

Oleoylethanolamide (OEA) is a naturally occurring bioactive lipid belonging to the family of N-acylethanolamides. A variety of beneficial effects have been attributed to OEA, although the greater interest is due to its potential role in the treatment of obesity, fatty liver, and eating-related disor...

Full description

Bibliographic Details
Main Authors:	Adele Romano, Marzia Friuli, Laura Del Coco, Serena Longo, Daniele Vergara, Piero Del Boccio, Silvia Valentinuzzi, Ilaria Cicalini, Francesco P. Fanizzi, Silvana Gaetani, Anna M. Giudetti
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	Nutrients
Subjects:	lipid metabolism oleoylethanolamide peroxisome proliferator-activated receptorγ NMR spectroscopy sphingolipids
Online Access:	https://www.mdpi.com/2072-6643/13/2/394

Similar Items

Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats
by: Anna Maria Giudetti, et al.
Published: (2021-08-01)

Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats
by: Long Li, et al.
Published: (2015-03-01)

Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease
by: Michele M. Comerota, et al.
Published: (2023-08-01)

Oleoylethanolamide Protects against Acute Ischemic Stroke by Promoting PPARα-Mediated Microglia/Macrophage M2 Polarization
by: Ying Li, et al.
Published: (2023-04-01)

Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse
by: Laura Orio, et al.
Published: (2019-01-01)

Oleoylethanolamide attenuates cocaine-primed reinstatement and alters dopaminergic gene expression in the striatum
by: Macarena González-Portilla, et al.
Published: (2023-05-01)

Effect of Oleoylethanolamide-Based Dietary Supplement on Systemic Inflammation in the Development of Alimentary-Induced Obesity in Mice
by: Darya Ivashkevich, et al.
Published: (2023-10-01)

Oleoylethanolamide and Palmitoylethanolamide Enhance IFNβ-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
by: Chiara Camoglio, et al.
Published: (2024-04-01)

Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
by: Miki Igarashi, et al.
Published: (2023-01-01)

Oleoylethanolamide Treatment Modulates Both Neuroinflammation and Microgliosis, and Prevents Massive Leukocyte Infiltration to the Cerebellum in a Mouse Model of Neuronal Degeneration
by: Ester Pérez-Martín, et al.
Published: (2023-06-01)

GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide
by: Dong-Soon Im
Published: (2021-01-01)

Effects of oleoylethanolamide supplementation on inflammatory biomarkers, oxidative stress and antioxidant parameters of obese patients with NAFLD on a calorie-restricted diet: A randomized controlled trial
by: Helda Tutunchi, et al.
Published: (2023-04-01)

The Role of PPAR Alpha in the Modulation of Innate Immunity
by: Maja Grabacka, et al.
Published: (2021-09-01)

Oleoylethanolamide attenuates acute-to-chronic kidney injury: in vivo and in vitro evidence of PPAR-α involvement
by: Federica Comella, et al.
Published: (2024-02-01)

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid
by: Consuelo Santa-María, et al.
Published: (2023-01-01)

Lipidomic Analysis of TRPC1 Ca2+-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet
by: Michael R. Bukowski, et al.
Published: (2022-03-01)

Involvement of the vagus nerve in the anorectic effect of monoacylglycerol acyltransferase 2 inhibition in mice
by: Kosuke Takemoto, et al.
Published: (2023-12-01)

Corrigendum: Lipidomic Analysis of TRPC1 Ca2+-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet
by: Michael R. Bukowski, et al.
Published: (2022-06-01)

Triacylglycerol metabolism in adipose tissue
by: Frayn, K, et al.
Published: (2004)

Using total plasma triacylglycerol to assess hepatic de novo lipogenesis as an alternative to VLDL triacylglycerol
by: Hodson, L, et al.
Published: (2020)

Using total plasma triacylglycerol to assess hepatic de novo lipogenesis as an alternative to VLDL triacylglycerol
by: Leanne Hodson, et al.
Published: (2020-07-01)

Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract
by: Takumi Takahashi, et al.
Published: (2022-11-01)

The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function
by: Gray Elizabeth, et al.
Published: (2012-04-01)

The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation
by: Hyemin Gu, et al.
Published: (2022-12-01)

Low-density lipoprotein-triacylglycerol and susceptibility to oxidation before and after infusion of a triacylglycerol emulsion in humans
by: Callow, J, et al.
Published: (1997)

The Role of Triacylglycerol in Plant Stress Response
by: Junhao Lu, et al.
Published: (2020-04-01)

Analysing the repercussions of ultrasound on triacylglycerols in food
by: Harsh B. Jadhav, et al.
Published: (2023-10-01)

“To brain or not to brain”: evaluating the possible direct effects of the satiety factor oleoylethanolamide in the central nervous system
by: Adele Romano, et al.
Published: (2023-05-01)

Evaluation of the Relationship between Peroxisome Proliferator Receptors (PPARα, PPARγ, and PPARδ) Expression and Carcinoembryonic Antigen (CEA) in Patients with Colorectal Cancer
by: Musa Yaghoubizadeh, et al.
Published: (2022-08-01)

Intestinal GPR119 activation by microbiota-derived metabolites impacts feeding behavior and energy metabolism
by: Miki Igarashi, et al.
Published: (2023-01-01)

Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial
by: Xi Fang, et al.
Published: (2022-07-01)

Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) <it>in vitro</it>
by: Dionisi Mauro, et al.
Published: (2012-05-01)

Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ
by: Tan, Nguan Soon, et al.
Published: (2017)

Moderate exercise, postprandial lipaemia and triacylglycerol clearance.
by: Gill, J, et al.
Published: (2001)

Improving the co-production of triacylglycerol and isoprenoids in Chlamydomonas
by: Supakorn Potijun, et al.
Published: (2020-12-01)

Triacylglycerols and Other Lipids Profiling of Hemp By-Products
by: Arjun H. Banskota, et al.
Published: (2022-04-01)

An Insight into the Solid-State Miscibility of Triacylglycerol Crystals
by: Jorge Macridachis-González, et al.
Published: (2020-10-01)

Content of polymerised triacylglycerols in fat of fried foods
by: Liliya Mekhanoshina, et al.
Published: (2016-06-01)

Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome
by: Tan, Chek Kun, et al.
Published: (2017)

Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
by: Jian Dai, et al.
Published: (2021-01-01)