Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2
The investigators carried out an analysis of the efficacy and safety of secukinumab (SEC) in the randomized placebocontrolled trials (RPCTs) FUTURE 1 and FUTURE 2, as well as a subanalysis of the data obtained in the Russian population of patients with active psoriatic arthritis (PsA). The FUTURE 1...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2017-04-01
|
| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/3003 |
| _version_ | 1826555870443470848 |
|---|---|
| author | T. V. Korotaeva E. G. Zotkin O. B. Nesmeyanova N. N. Vezikova O. B. Ershova N. V. Izmozzherova M. S. Petrova A. A. Kastanyan S. P. Yakupova A. S. Agafina M. L. Stanislav E. A. Novoderezhkina E. L. Nasonov P. J. Mease |
| author_facet | T. V. Korotaeva E. G. Zotkin O. B. Nesmeyanova N. N. Vezikova O. B. Ershova N. V. Izmozzherova M. S. Petrova A. A. Kastanyan S. P. Yakupova A. S. Agafina M. L. Stanislav E. A. Novoderezhkina E. L. Nasonov P. J. Mease |
| author_sort | T. V. Korotaeva |
| collection | DOAJ |
| description | The investigators carried out an analysis of the efficacy and safety of secukinumab (SEC) in the randomized placebocontrolled trials (RPCTs) FUTURE 1 and FUTURE 2, as well as a subanalysis of the data obtained in the Russian population of patients with active psoriatic arthritis (PsA). The FUTURE 1 and FUTURE 2 trials enrolled a total of 1003 patients with active PsA. They received SEC (n = 703) or placebo (PL) (n = 300). The use of SEC 300 or 150 mg without previous intravenous (IV) loading dose or either 150 or 75 mg with the IV loading dose led to a significant improvement in patients with PsA. The positive changes in the main clinical manifestations of PsA at 24 weeks persisted until 52 weeks of therapy. SEC was effective in both the patients who had not previously received tumor necrosis factor-α inhibitors and those who had previously taken these drugs, and the result of therapy did not depend on concomitant methotrexate use.The incidence of cancer was low and comparable in the SEC and PL groups. Analysis of the combined data on the safety of the two RPCTs showed that the treatment duration-adjusted incidence of malignant neoplasms was 0.5 per 100 patient-years in the SEC groups and 0.9 in the PL groups. The safety profile of SEC in these RPCTs corresponds to that in the previous studies of the drug.The data from the pooled analysis of the Russian subpopulation of patients with PsA fully agree with the results obtained in the evaluation of all the patients included in FUTURE 1 and FUTURE 2 and confirm the most important role of IL-17А in the pathogenesis of PsA. |
| first_indexed | 2024-04-09T22:22:35Z |
| format | Article |
| id | doaj.art-34fb875b67194d3092c5fcc5ffa735cb |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2025-03-14T08:03:41Z |
| publishDate | 2017-04-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-34fb875b67194d3092c5fcc5ffa735cb2025-03-02T13:23:49ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922017-04-0155215115810.14412/1995-4484-2017-151-1582691Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2T. V. Korotaeva0E. G. Zotkin1O. B. Nesmeyanova2N. N. Vezikova3O. B. Ershova4N. V. Izmozzherova5M. S. Petrova6A. A. Kastanyan7S. P. Yakupova8A. S. Agafina9M. L. Stanislav10E. A. Novoderezhkina11E. L. Nasonov12P. J. Mease13V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyChelyabinsk Regional Clinical HospitalV.A. Baranov Republican HospitalN.V. Solovyev Clinical Hospital of Emergency Medical CareUral State Medical University, Ministry of Health of RussiaClinical Rheumatology Hospital Twenty-FiveRostov State Medical University, Ministry of Health of RussiaOOO «Your Health» Research Medical ComplexCity Hospital Forty, Kurortnyi DistrictV.A. Nasonova Research Institute of RheumatologyOOO «Novartis Farma»V.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaSwedish Medical Center and University of WashingtonThe investigators carried out an analysis of the efficacy and safety of secukinumab (SEC) in the randomized placebocontrolled trials (RPCTs) FUTURE 1 and FUTURE 2, as well as a subanalysis of the data obtained in the Russian population of patients with active psoriatic arthritis (PsA). The FUTURE 1 and FUTURE 2 trials enrolled a total of 1003 patients with active PsA. They received SEC (n = 703) or placebo (PL) (n = 300). The use of SEC 300 or 150 mg without previous intravenous (IV) loading dose or either 150 or 75 mg with the IV loading dose led to a significant improvement in patients with PsA. The positive changes in the main clinical manifestations of PsA at 24 weeks persisted until 52 weeks of therapy. SEC was effective in both the patients who had not previously received tumor necrosis factor-α inhibitors and those who had previously taken these drugs, and the result of therapy did not depend on concomitant methotrexate use.The incidence of cancer was low and comparable in the SEC and PL groups. Analysis of the combined data on the safety of the two RPCTs showed that the treatment duration-adjusted incidence of malignant neoplasms was 0.5 per 100 patient-years in the SEC groups and 0.9 in the PL groups. The safety profile of SEC in these RPCTs corresponds to that in the previous studies of the drug.The data from the pooled analysis of the Russian subpopulation of patients with PsA fully agree with the results obtained in the evaluation of all the patients included in FUTURE 1 and FUTURE 2 and confirm the most important role of IL-17А in the pathogenesis of PsA.https://rsp.mediar-press.net/rsp/article/view/3003psoriatic arthritissecukinumabefficacysafetyinterleukin-17 |
| spellingShingle | T. V. Korotaeva E. G. Zotkin O. B. Nesmeyanova N. N. Vezikova O. B. Ershova N. V. Izmozzherova M. S. Petrova A. A. Kastanyan S. P. Yakupova A. S. Agafina M. L. Stanislav E. A. Novoderezhkina E. L. Nasonov P. J. Mease Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2 Научно-практическая ревматология psoriatic arthritis secukinumab efficacy safety interleukin-17 |
| title | Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2 |
| title_full | Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2 |
| title_fullStr | Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2 |
| title_full_unstemmed | Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2 |
| title_short | Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2 |
| title_sort | use of the interleukin 17a inhibitor secukinumab in psoriatic arthritis a subanalysis of the russian population in the international randomized clinical trials future 1 and future 2 |
| topic | psoriatic arthritis secukinumab efficacy safety interleukin-17 |
| url | https://rsp.mediar-press.net/rsp/article/view/3003 |
| work_keys_str_mv | AT tvkorotaeva useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT egzotkin useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT obnesmeyanova useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT nnvezikova useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT obershova useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT nvizmozzherova useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT mspetrova useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT aakastanyan useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT spyakupova useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT asagafina useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT mlstanislav useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT eanovoderezhkina useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT elnasonov useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 AT pjmease useoftheinterleukin17ainhibitorsecukinumabinpsoriaticarthritisasubanalysisoftherussianpopulationintheinternationalrandomizedclinicaltrialsfuture1andfuture2 |