Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells. Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. By analysing iNKT cells from lymphoid tiss...

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Bibliographic Details
Main Authors: Rebeca Jimeno, Marta Lebrusant-Fernandez, Christian Margreitter, Beth Lucas, Natacha Veerapen, Gavin Kelly, Gurdyal S Besra, Franca Fraternali, Jo Spencer, Graham Anderson, Patricia Barral
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
NKT cell
TCR
lipid antigen
Online Access:https://elifesciences.org/articles/51663

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