Mesenchymal stem/stromal cell function in modulating cell death
Abstract Mesenchymal stem/stromal cells (MSCs) delivered as cell therapy to individuals with degenerative and/or inflammatory disorders can help improve organ features and resolve inflammation, as demonstrated in preclinical studies and to some extent in clinical studies. MSCs have trophic, homing/m...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-019-1158-4 |
| _version_ | 1818025189804343296 |
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| author | Abderrahim Naji Benoit Favier Frédéric Deschaseaux Nathalie Rouas-Freiss Masamitsu Eitoku Narufumi Suganuma |
| author_facet | Abderrahim Naji Benoit Favier Frédéric Deschaseaux Nathalie Rouas-Freiss Masamitsu Eitoku Narufumi Suganuma |
| author_sort | Abderrahim Naji |
| collection | DOAJ |
| description | Abstract Mesenchymal stem/stromal cells (MSCs) delivered as cell therapy to individuals with degenerative and/or inflammatory disorders can help improve organ features and resolve inflammation, as demonstrated in preclinical studies and to some extent in clinical studies. MSCs have trophic, homing/migration, and immunosuppression functions, with many benefits in therapeutics. MSC functions are thought to depend on the paracrine action of soluble factors and/or the expression of membrane-bound molecules, mostly belonging to the molecular class of adhesion molecules, chemokines, enzymes, growth factors, and interleukins. Cutting-edge studies underline bioactive exchanges, including that of ions, nucleic acids, proteins, and organelles transferred from MSCs to stressed cells, thereby improving the cells’ survival and function. From this aspect, MSC death modulation function appears as a decisive biological function that could carry a significant part of the therapeutic effects of MSCs. Identifying the function and modes of actions of MSCs in modulating cell death may be exploited to enhance consistency and efficiency of cell therapy that is based on MSCs as medical treatment for degenerative and/or inflammatory diseases. Here, we review the essentials of MSC functions in modulating cell death in unfit cells, and its modes of actions based on current advances and outline the clinical implications. |
| first_indexed | 2024-12-10T04:12:10Z |
| format | Article |
| id | doaj.art-34fe7d5abfc8476a9a5e3ef5a10dd672 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-10T04:12:10Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-34fe7d5abfc8476a9a5e3ef5a10dd6722022-12-22T02:02:42ZengBMCStem Cell Research & Therapy1757-65122019-02-0110111210.1186/s13287-019-1158-4Mesenchymal stem/stromal cell function in modulating cell deathAbderrahim Naji0Benoit Favier1Frédéric Deschaseaux2Nathalie Rouas-Freiss3Masamitsu Eitoku4Narufumi Suganuma5Department of Environmental Medicine, Cooperative Medicine Unit, Research and Education Faculty, Medicine Science Cluster, Kochi Medical School (KMS), Kochi UniversityCEA-Université Paris Sud INSERM U1184, IDMIT Department, IBFJ, DRFSTROMALab, UMR 5273 CNRS, INSERM U1031, Etablissement Français du Sang (EFS) Occitanie, Université de ToulouseCEA, DRF-Institut Francois Jacob, Division de recherche en hématologie et immunologie (SRHI), Hôpital Saint-LouisDepartment of Environmental Medicine, Cooperative Medicine Unit, Research and Education Faculty, Medicine Science Cluster, Kochi Medical School (KMS), Kochi UniversityDepartment of Environmental Medicine, Cooperative Medicine Unit, Research and Education Faculty, Medicine Science Cluster, Kochi Medical School (KMS), Kochi UniversityAbstract Mesenchymal stem/stromal cells (MSCs) delivered as cell therapy to individuals with degenerative and/or inflammatory disorders can help improve organ features and resolve inflammation, as demonstrated in preclinical studies and to some extent in clinical studies. MSCs have trophic, homing/migration, and immunosuppression functions, with many benefits in therapeutics. MSC functions are thought to depend on the paracrine action of soluble factors and/or the expression of membrane-bound molecules, mostly belonging to the molecular class of adhesion molecules, chemokines, enzymes, growth factors, and interleukins. Cutting-edge studies underline bioactive exchanges, including that of ions, nucleic acids, proteins, and organelles transferred from MSCs to stressed cells, thereby improving the cells’ survival and function. From this aspect, MSC death modulation function appears as a decisive biological function that could carry a significant part of the therapeutic effects of MSCs. Identifying the function and modes of actions of MSCs in modulating cell death may be exploited to enhance consistency and efficiency of cell therapy that is based on MSCs as medical treatment for degenerative and/or inflammatory diseases. Here, we review the essentials of MSC functions in modulating cell death in unfit cells, and its modes of actions based on current advances and outline the clinical implications.http://link.springer.com/article/10.1186/s13287-019-1158-4Mesenchymal stem cellCell functionCell deathCell therapy |
| spellingShingle | Abderrahim Naji Benoit Favier Frédéric Deschaseaux Nathalie Rouas-Freiss Masamitsu Eitoku Narufumi Suganuma Mesenchymal stem/stromal cell function in modulating cell death Stem Cell Research & Therapy Mesenchymal stem cell Cell function Cell death Cell therapy |
| title | Mesenchymal stem/stromal cell function in modulating cell death |
| title_full | Mesenchymal stem/stromal cell function in modulating cell death |
| title_fullStr | Mesenchymal stem/stromal cell function in modulating cell death |
| title_full_unstemmed | Mesenchymal stem/stromal cell function in modulating cell death |
| title_short | Mesenchymal stem/stromal cell function in modulating cell death |
| title_sort | mesenchymal stem stromal cell function in modulating cell death |
| topic | Mesenchymal stem cell Cell function Cell death Cell therapy |
| url | http://link.springer.com/article/10.1186/s13287-019-1158-4 |
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