Corneal antinociceptive effect of (-)-α-bisabolol
Context: (-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. Objective: To evaluate the corneal antinociceptive efficacy of BISA and to analyze the be...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Pharmaceutical Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/13880209.2017.1285944 |
| _version_ | 1818161377964982272 |
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| author | Gisele Façanha Diógenes Teixeira Flávio Nogueira da Costa Adriana Rolim Campos |
| author_facet | Gisele Façanha Diógenes Teixeira Flávio Nogueira da Costa Adriana Rolim Campos |
| author_sort | Gisele Façanha Diógenes Teixeira |
| collection | DOAJ |
| description | Context: (-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. Objective: To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent. Materials and methods: Acute corneal nociception was induced by the local application of hypertonic saline (5 M NaCl; 20 μL) to the corneal surface of Swiss mice (n = 8/group) 60 min after topical treatment with solutions or ointment containing BISA (50–200 mg/mL). The number of eye wipes performed with the ipsilateral forepaw was counted for a period of 30 s. Control groups (vehicles) were included. Results: BISA (50, 100 or 200 mg/mL) solubilized with Tween 80 did not reduce the number of eye wipes. Animals treated with the ointment (BISA 50, 100 or 200 mg/mL; p < 0.001), as well the solution containing propylene glycol (BISA 100 mg/mL; p < 0.05), showed significant reduction in the number of nociceptive behaviours. Solutions containing propylene glycol and isopropyl myristate had no effects. Discussion and conclusion: BISA possess corneal antinociceptive activity. Although the ointment presented antinociceptive effect, it is concluded that BISA when associated with propylene glycol has better potential for corneal nociceptive pain since it is more comfortable to use, leading to greater acceptance by patients. |
| first_indexed | 2024-12-11T16:16:49Z |
| format | Article |
| id | doaj.art-34ff87e1e0b340b7add077109a697198 |
| institution | Directory Open Access Journal |
| issn | 1388-0209 1744-5116 |
| language | English |
| last_indexed | 2024-12-11T16:16:49Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Pharmaceutical Biology |
| spelling | doaj.art-34ff87e1e0b340b7add077109a6971982022-12-22T00:58:55ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162017-01-015511089109210.1080/13880209.2017.12859441285944Corneal antinociceptive effect of (-)-α-bisabololGisele Façanha Diógenes Teixeira0Flávio Nogueira da Costa1Adriana Rolim Campos2, University of Fortaleza (Unifor), University of Fortaleza (Unifor), University of Fortaleza (Unifor)Context: (-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. Objective: To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent. Materials and methods: Acute corneal nociception was induced by the local application of hypertonic saline (5 M NaCl; 20 μL) to the corneal surface of Swiss mice (n = 8/group) 60 min after topical treatment with solutions or ointment containing BISA (50–200 mg/mL). The number of eye wipes performed with the ipsilateral forepaw was counted for a period of 30 s. Control groups (vehicles) were included. Results: BISA (50, 100 or 200 mg/mL) solubilized with Tween 80 did not reduce the number of eye wipes. Animals treated with the ointment (BISA 50, 100 or 200 mg/mL; p < 0.001), as well the solution containing propylene glycol (BISA 100 mg/mL; p < 0.05), showed significant reduction in the number of nociceptive behaviours. Solutions containing propylene glycol and isopropyl myristate had no effects. Discussion and conclusion: BISA possess corneal antinociceptive activity. Although the ointment presented antinociceptive effect, it is concluded that BISA when associated with propylene glycol has better potential for corneal nociceptive pain since it is more comfortable to use, leading to greater acceptance by patients.http://dx.doi.org/10.1080/13880209.2017.1285944sesquiterpenesolubilizing agentscorneal pain |
| spellingShingle | Gisele Façanha Diógenes Teixeira Flávio Nogueira da Costa Adriana Rolim Campos Corneal antinociceptive effect of (-)-α-bisabolol Pharmaceutical Biology sesquiterpene solubilizing agents corneal pain |
| title | Corneal antinociceptive effect of (-)-α-bisabolol |
| title_full | Corneal antinociceptive effect of (-)-α-bisabolol |
| title_fullStr | Corneal antinociceptive effect of (-)-α-bisabolol |
| title_full_unstemmed | Corneal antinociceptive effect of (-)-α-bisabolol |
| title_short | Corneal antinociceptive effect of (-)-α-bisabolol |
| title_sort | corneal antinociceptive effect of α bisabolol |
| topic | sesquiterpene solubilizing agents corneal pain |
| url | http://dx.doi.org/10.1080/13880209.2017.1285944 |
| work_keys_str_mv | AT giselefacanhadiogenesteixeira cornealantinociceptiveeffectofabisabolol AT flavionogueiradacosta cornealantinociceptiveeffectofabisabolol AT adrianarolimcampos cornealantinociceptiveeffectofabisabolol |