Advances and applications of nanoparticles in cancer therapy
Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for e...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
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| Series: | MedComm – Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mog2.67 |
| _version_ | 1797235592806793216 |
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| author | Xianzhou Huang Tao He Xiuqi Liang Zhongzheng Xiang Chao Liu Shiyao Zhou Rui Luo Liping Bai Xiaorong Kou Xinchao Li Rui Wu Xinyu Gou Xinyue Wu Dongxue Huang Wangxian Fu Yingjie Li Ruhan Chen Ningyue Xu Yixi Wang Hao Le Tao Chen Yangsong Xu Yuting Tang Changyang Gong |
| author_facet | Xianzhou Huang Tao He Xiuqi Liang Zhongzheng Xiang Chao Liu Shiyao Zhou Rui Luo Liping Bai Xiaorong Kou Xinchao Li Rui Wu Xinyu Gou Xinyue Wu Dongxue Huang Wangxian Fu Yingjie Li Ruhan Chen Ningyue Xu Yixi Wang Hao Le Tao Chen Yangsong Xu Yuting Tang Changyang Gong |
| author_sort | Xianzhou Huang |
| collection | DOAJ |
| description | Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy. |
| first_indexed | 2024-04-24T16:50:25Z |
| format | Article |
| id | doaj.art-34ffa542c8ff4e709136348e7e9cae10 |
| institution | Directory Open Access Journal |
| issn | 2769-6448 |
| language | English |
| last_indexed | 2024-04-24T16:50:25Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Oncology |
| spelling | doaj.art-34ffa542c8ff4e709136348e7e9cae102024-03-29T03:56:48ZengWileyMedComm – Oncology2769-64482024-03-0131n/an/a10.1002/mog2.67Advances and applications of nanoparticles in cancer therapyXianzhou Huang0Tao He1Xiuqi Liang2Zhongzheng Xiang3Chao Liu4Shiyao Zhou5Rui Luo6Liping Bai7Xiaorong Kou8Xinchao Li9Rui Wu10Xinyu Gou11Xinyue Wu12Dongxue Huang13Wangxian Fu14Yingjie Li15Ruhan Chen16Ningyue Xu17Yixi Wang18Hao Le19Tao Chen20Yangsong Xu21Yuting Tang22Changyang Gong23Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Head and Neck Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Head and Neck Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu ChinaAbstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.https://doi.org/10.1002/mog2.67biomaterialscancer therapydrug deliverygene deliverynanoparticle |
| spellingShingle | Xianzhou Huang Tao He Xiuqi Liang Zhongzheng Xiang Chao Liu Shiyao Zhou Rui Luo Liping Bai Xiaorong Kou Xinchao Li Rui Wu Xinyu Gou Xinyue Wu Dongxue Huang Wangxian Fu Yingjie Li Ruhan Chen Ningyue Xu Yixi Wang Hao Le Tao Chen Yangsong Xu Yuting Tang Changyang Gong Advances and applications of nanoparticles in cancer therapy MedComm – Oncology biomaterials cancer therapy drug delivery gene delivery nanoparticle |
| title | Advances and applications of nanoparticles in cancer therapy |
| title_full | Advances and applications of nanoparticles in cancer therapy |
| title_fullStr | Advances and applications of nanoparticles in cancer therapy |
| title_full_unstemmed | Advances and applications of nanoparticles in cancer therapy |
| title_short | Advances and applications of nanoparticles in cancer therapy |
| title_sort | advances and applications of nanoparticles in cancer therapy |
| topic | biomaterials cancer therapy drug delivery gene delivery nanoparticle |
| url | https://doi.org/10.1002/mog2.67 |
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