The Influence of Oral Drotaverine Administration on Materno–Fetal Circulation during the Second and Third Trimester of Pregnancy
<i>Background and Objectives</i>: The study aimed to evaluate the effect of the oral administration of drotaverine on maternal and fetal circulation as measured by Doppler sonography in women with a risk of preterm birth. <i>Materials and Methods</i>: The present prospective...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/2/235 |
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| author | Paweł Rzymski Katarzyna Maria Tomczyk Maciej Wilczak |
| author_facet | Paweł Rzymski Katarzyna Maria Tomczyk Maciej Wilczak |
| author_sort | Paweł Rzymski |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The study aimed to evaluate the effect of the oral administration of drotaverine on maternal and fetal circulation as measured by Doppler sonography in women with a risk of preterm birth. <i>Materials and Methods</i>: The present prospective study was conducted on 34 women with singleton pregnancy at 26–36 weeks of gestation. Doppler flow and pulsatility index (PI) assessments of the umbilical artery, fetal middle cerebral artery, and uterine arteries were performed before and 90–120 min after oral drotaverine administration. <i>Results</i>: There were no statistically significant differences between the Doppler assessment (PI Uma—umbilical artery, MCA—middle cerebral artery, and ltUta—left uterine artery) before drotaverine administration and 90–120 min after oral intake, but there were statistically significant differences between the PI assessment of the rtUta (right uterine artery, 0.55 vs. 0.75, <i>p</i> = 0.05) and the mean of the Uta (0.66 vs. 0.74, <i>p</i> = 0.03). For changes in the CUR (cerebro–umbilical ratio) and % changes in the CUR and mean PI of the Uta, there was no correlation with obstetric history, AFI (amniotic fluid index), gestation week, infertility history, systolic pressure, or diastolic pressure. There was a statistically positive correlation between changes in the CUR and % change in the CUR and body weight and in height. <i>Conclusions</i>: Drotaverine has no statistically significant influence on the MCA and Uma PI. The oral administration of drotaverine has an impact on PI rtUta and the mean PI Uta. |
| first_indexed | 2024-03-09T21:29:20Z |
| format | Article |
| id | doaj.art-3500809f61924b5b8d4b61f9d6811159 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T21:29:20Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-3500809f61924b5b8d4b61f9d68111592023-11-23T21:00:08ZengMDPI AGMedicina1010-660X1648-91442022-02-0158223510.3390/medicina58020235The Influence of Oral Drotaverine Administration on Materno–Fetal Circulation during the Second and Third Trimester of PregnancyPaweł Rzymski0Katarzyna Maria Tomczyk1Maciej Wilczak2Department of Mother’s and Child’s Health, Gynecologic and Obstetrical University Hospital, Poznan University of Medical Sciences, Polna St 33, 60-535 Poznan, PolandDepartment of Mother’s and Child’s Health, Gynecologic and Obstetrical University Hospital, Poznan University of Medical Sciences, Polna St 33, 60-535 Poznan, PolandDepartment of Mother’s and Child’s Health, Gynecologic and Obstetrical University Hospital, Poznan University of Medical Sciences, Polna St 33, 60-535 Poznan, Poland<i>Background and Objectives</i>: The study aimed to evaluate the effect of the oral administration of drotaverine on maternal and fetal circulation as measured by Doppler sonography in women with a risk of preterm birth. <i>Materials and Methods</i>: The present prospective study was conducted on 34 women with singleton pregnancy at 26–36 weeks of gestation. Doppler flow and pulsatility index (PI) assessments of the umbilical artery, fetal middle cerebral artery, and uterine arteries were performed before and 90–120 min after oral drotaverine administration. <i>Results</i>: There were no statistically significant differences between the Doppler assessment (PI Uma—umbilical artery, MCA—middle cerebral artery, and ltUta—left uterine artery) before drotaverine administration and 90–120 min after oral intake, but there were statistically significant differences between the PI assessment of the rtUta (right uterine artery, 0.55 vs. 0.75, <i>p</i> = 0.05) and the mean of the Uta (0.66 vs. 0.74, <i>p</i> = 0.03). For changes in the CUR (cerebro–umbilical ratio) and % changes in the CUR and mean PI of the Uta, there was no correlation with obstetric history, AFI (amniotic fluid index), gestation week, infertility history, systolic pressure, or diastolic pressure. There was a statistically positive correlation between changes in the CUR and % change in the CUR and body weight and in height. <i>Conclusions</i>: Drotaverine has no statistically significant influence on the MCA and Uma PI. The oral administration of drotaverine has an impact on PI rtUta and the mean PI Uta.https://www.mdpi.com/1648-9144/58/2/235Doppler sonographydrotaverinepreterm birthmaterno–fetal circulation |
| spellingShingle | Paweł Rzymski Katarzyna Maria Tomczyk Maciej Wilczak The Influence of Oral Drotaverine Administration on Materno–Fetal Circulation during the Second and Third Trimester of Pregnancy Medicina Doppler sonography drotaverine preterm birth materno–fetal circulation |
| title | The Influence of Oral Drotaverine Administration on Materno–Fetal Circulation during the Second and Third Trimester of Pregnancy |
| title_full | The Influence of Oral Drotaverine Administration on Materno–Fetal Circulation during the Second and Third Trimester of Pregnancy |
| title_fullStr | The Influence of Oral Drotaverine Administration on Materno–Fetal Circulation during the Second and Third Trimester of Pregnancy |
| title_full_unstemmed | The Influence of Oral Drotaverine Administration on Materno–Fetal Circulation during the Second and Third Trimester of Pregnancy |
| title_short | The Influence of Oral Drotaverine Administration on Materno–Fetal Circulation during the Second and Third Trimester of Pregnancy |
| title_sort | influence of oral drotaverine administration on materno fetal circulation during the second and third trimester of pregnancy |
| topic | Doppler sonography drotaverine preterm birth materno–fetal circulation |
| url | https://www.mdpi.com/1648-9144/58/2/235 |
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