TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO
The article is devoted to the investigation of the possibility of immobilized on the surface of the titanium implantable devices (model plates, “U-shaped” brackets) antimicrobial substances.Material and methods. The object of research were modeling titanium plates and titanium “U-shaped” brackets fo...
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Format: | Article |
Language: | English |
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Siberian State Medical University (Tomsk)
2016-06-01
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Series: | Бюллетень сибирской медицины |
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Online Access: | https://bulletin.ssmu.ru/jour/article/view/585 |
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author | V. V. Sheykin Y. A. Shelikhova E. N. Moskvitina A. N. Osipov V. V. Yermakov V. S. Chuchalin A. N. Melenteva |
author_facet | V. V. Sheykin Y. A. Shelikhova E. N. Moskvitina A. N. Osipov V. V. Yermakov V. S. Chuchalin A. N. Melenteva |
author_sort | V. V. Sheykin |
collection | DOAJ |
description | The article is devoted to the investigation of the possibility of immobilized on the surface of the titanium implantable devices (model plates, “U-shaped” brackets) antimicrobial substances.Material and methods. The object of research were modeling titanium plates and titanium “U-shaped” brackets for implantation. Ciprofloxacin, hydroxypropylmethylcellulose and methylcellulose has been proposed as materials for the creation of antimicrobial pharmaceutical composition to immobilization. The antimicrobial properties of titanium implantable “U-shaped” brackets with ciprofloxacin was evaluated for potential antimicrobial activity against medically important bacterial (S. aureus, P. aeruginosa, E. coli, E. faecalis and S. pyogenes) using method of diffusion in agar. Results. The results showed the possibility of putting and holding а ciprofloxacin in grooves on the modified surface of titanium implants. In the course of the study was developed a pharmaceutical composition, comprising ciprofloxacin and hydroxypropylmethylcellulose. The results showed high antimicrobial activity of pharmaceutical composition with ciprofloxacin against the test organisms (S. aureus, P. aeruginosa, E. coli, E. faecalis and S. pyogenes). |
first_indexed | 2024-04-10T01:07:16Z |
format | Article |
id | doaj.art-3501ff64954442cc83c3329fbbd3b8ac |
institution | Directory Open Access Journal |
issn | 1682-0363 1819-3684 |
language | English |
last_indexed | 2024-04-10T01:07:16Z |
publishDate | 2016-06-01 |
publisher | Siberian State Medical University (Tomsk) |
record_format | Article |
series | Бюллетень сибирской медицины |
spelling | doaj.art-3501ff64954442cc83c3329fbbd3b8ac2023-03-13T09:58:22ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842016-06-01152768410.20538/1682-0363-2016-2-76-84534TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITROV. V. Sheykin0Y. A. Shelikhova1E. N. Moskvitina2A. N. Osipov3V. V. Yermakov4V. S. Chuchalin5A. N. Melenteva6Сибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскСибирский федеральный научно-клинический центр Федерального медико-биологического агентства, Томская обл., СеверсТомский медицинский инструмент, ТомскТомский медицинский инструмент, ТомскСибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскThe article is devoted to the investigation of the possibility of immobilized on the surface of the titanium implantable devices (model plates, “U-shaped” brackets) antimicrobial substances.Material and methods. The object of research were modeling titanium plates and titanium “U-shaped” brackets for implantation. Ciprofloxacin, hydroxypropylmethylcellulose and methylcellulose has been proposed as materials for the creation of antimicrobial pharmaceutical composition to immobilization. The antimicrobial properties of titanium implantable “U-shaped” brackets with ciprofloxacin was evaluated for potential antimicrobial activity against medically important bacterial (S. aureus, P. aeruginosa, E. coli, E. faecalis and S. pyogenes) using method of diffusion in agar. Results. The results showed the possibility of putting and holding а ciprofloxacin in grooves on the modified surface of titanium implants. In the course of the study was developed a pharmaceutical composition, comprising ciprofloxacin and hydroxypropylmethylcellulose. The results showed high antimicrobial activity of pharmaceutical composition with ciprofloxacin against the test organisms (S. aureus, P. aeruginosa, E. coli, E. faecalis and S. pyogenes).https://bulletin.ssmu.ru/jour/article/view/585имплантат«п-образная» скобкаципрофлоксацинфармацевтическая композицияантимикробная активность |
spellingShingle | V. V. Sheykin Y. A. Shelikhova E. N. Moskvitina A. N. Osipov V. V. Yermakov V. S. Chuchalin A. N. Melenteva TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO Бюллетень сибирской медицины имплантат «п-образная» скобка ципрофлоксацин фармацевтическая композиция антимикробная активность |
title | TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO |
title_full | TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO |
title_fullStr | TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO |
title_full_unstemmed | TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO |
title_short | TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO |
title_sort | technological basis for the creation of implants with a pharmaceutical composition of ciprofloxacin and their antimicrobial activity in experiments in vitro |
topic | имплантат «п-образная» скобка ципрофлоксацин фармацевтическая композиция антимикробная активность |
url | https://bulletin.ssmu.ru/jour/article/view/585 |
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