TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO

The article is devoted to the investigation of the possibility of immobilized on the surface of the titanium implantable devices (model plates, “U-shaped” brackets) antimicrobial substances.Material and methods. The object of research were modeling titanium plates and titanium “U-shaped” brackets fo...

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Main Authors: V. V. Sheykin, Y. A. Shelikhova, E. N. Moskvitina, A. N. Osipov, V. V. Yermakov, V. S. Chuchalin, A. N. Melenteva
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2016-06-01
Series:Бюллетень сибирской медицины
Subjects:
Online Access:https://bulletin.ssmu.ru/jour/article/view/585
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author V. V. Sheykin
Y. A. Shelikhova
E. N. Moskvitina
A. N. Osipov
V. V. Yermakov
V. S. Chuchalin
A. N. Melenteva
author_facet V. V. Sheykin
Y. A. Shelikhova
E. N. Moskvitina
A. N. Osipov
V. V. Yermakov
V. S. Chuchalin
A. N. Melenteva
author_sort V. V. Sheykin
collection DOAJ
description The article is devoted to the investigation of the possibility of immobilized on the surface of the titanium implantable devices (model plates, “U-shaped” brackets) antimicrobial substances.Material and methods. The object of research were modeling titanium plates and titanium “U-shaped” brackets for implantation. Ciprofloxacin, hydroxypropylmethylcellulose and methylcellulose has been proposed as materials for the creation of antimicrobial pharmaceutical composition to immobilization. The antimicrobial properties of titanium implantable “U-shaped” brackets with ciprofloxacin was evaluated for potential antimicrobial activity against medically important bacterial (S. aureus, P. aeruginosa, E. coli, E. faecalis and S. pyogenes) using method of diffusion in agar. Results. The results showed the possibility of putting and holding а ciprofloxacin in grooves on the modified surface of titanium implants. In the course of the study was developed a pharmaceutical composition, comprising ciprofloxacin and hydroxypropylmethylcellulose. The results showed high antimicrobial activity of pharmaceutical composition with ciprofloxacin against the test organisms (S. aureus, P. aeruginosa, E. coli, E. faecalis and S. pyogenes).
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spelling doaj.art-3501ff64954442cc83c3329fbbd3b8ac2023-03-13T09:58:22ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842016-06-01152768410.20538/1682-0363-2016-2-76-84534TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITROV. V. Sheykin0Y. A. Shelikhova1E. N. Moskvitina2A. N. Osipov3V. V. Yermakov4V. S. Chuchalin5A. N. Melenteva6Сибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскСибирский федеральный научно-клинический центр Федерального медико-биологического агентства, Томская обл., СеверсТомский медицинский инструмент, ТомскТомский медицинский инструмент, ТомскСибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскThe article is devoted to the investigation of the possibility of immobilized on the surface of the titanium implantable devices (model plates, “U-shaped” brackets) antimicrobial substances.Material and methods. The object of research were modeling titanium plates and titanium “U-shaped” brackets for implantation. Ciprofloxacin, hydroxypropylmethylcellulose and methylcellulose has been proposed as materials for the creation of antimicrobial pharmaceutical composition to immobilization. The antimicrobial properties of titanium implantable “U-shaped” brackets with ciprofloxacin was evaluated for potential antimicrobial activity against medically important bacterial (S. aureus, P. aeruginosa, E. coli, E. faecalis and S. pyogenes) using method of diffusion in agar. Results. The results showed the possibility of putting and holding а ciprofloxacin in grooves on the modified surface of titanium implants. In the course of the study was developed a pharmaceutical composition, comprising ciprofloxacin and hydroxypropylmethylcellulose. The results showed high antimicrobial activity of pharmaceutical composition with ciprofloxacin against the test organisms (S. aureus, P. aeruginosa, E. coli, E. faecalis and S. pyogenes).https://bulletin.ssmu.ru/jour/article/view/585имплантат«п-образная» скобкаципрофлоксацинфармацевтическая композицияантимикробная активность
spellingShingle V. V. Sheykin
Y. A. Shelikhova
E. N. Moskvitina
A. N. Osipov
V. V. Yermakov
V. S. Chuchalin
A. N. Melenteva
TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO
Бюллетень сибирской медицины
имплантат
«п-образная» скобка
ципрофлоксацин
фармацевтическая композиция
антимикробная активность
title TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO
title_full TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO
title_fullStr TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO
title_full_unstemmed TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO
title_short TECHNOLOGICAL BASIS FOR THE CREATION OF IMPLANTS WITH A PHARMACEUTICAL COMPOSITION OF CIPROFLOXACIN AND THEIR ANTIMICROBIAL ACTIVITY IN EXPERIMENTS IN VITRO
title_sort technological basis for the creation of implants with a pharmaceutical composition of ciprofloxacin and their antimicrobial activity in experiments in vitro
topic имплантат
«п-образная» скобка
ципрофлоксацин
фармацевтическая композиция
антимикробная активность
url https://bulletin.ssmu.ru/jour/article/view/585
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