β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise
Obese individuals present anomalous immune/inflammatory responses with dysregulations in neuroendocrine responses and immune/stress feedback mechanisms. In this context, exercise and β2 adrenergic activation present monocyte-mediated anti-inflammatory effects that are modulated by obesity. However,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1438 |
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| author | Isabel Gálvez Leticia Martín-Cordero María Dolores Hinchado Eduardo Ortega |
| author_facet | Isabel Gálvez Leticia Martín-Cordero María Dolores Hinchado Eduardo Ortega |
| author_sort | Isabel Gálvez |
| collection | DOAJ |
| description | Obese individuals present anomalous immune/inflammatory responses with dysregulations in neuroendocrine responses and immune/stress feedback mechanisms. In this context, exercise and β2 adrenergic activation present monocyte-mediated anti-inflammatory effects that are modulated by obesity. However, these anti-inflammatory effects could immunocompromise the monocyte-mediated innate response against a pathogen challenge. Thus, the objective of this work was to evaluate the effect of obesity, and exercise in this condition, on the β2 adrenergic regulation of the phagocytic and microbicide capacity of circulating monocytes. C57BL/6J mice were allocated to different sedentary or exercised, lean or obese groups. Obese mice showed a lower monocyte-mediated innate response than that of lean mice. Globally, selective β2 adrenergic receptor agonist terbutaline decreased the innate response of monocytes from lean and obese sedentary animals, whereas exercise stimulated it. Exercise modulates β2 adrenergic regulation of the innate response in lean and obese animals, with a global stimulatory or neutral effect, thus abolishing the inhibitory effect of terbutaline occurring in sedentary animals. These effects cannot be explained only by changes in the surface expression of toll-like receptors. Therefore, in general, terbutaline does not hinder the effects of regular exercise, but regular exercise does abolish the effects of terbutaline in sedentary individuals. |
| first_indexed | 2024-03-10T19:47:27Z |
| format | Article |
| id | doaj.art-3505bc5c162f4190b46be99b811aa259 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:47:27Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3505bc5c162f4190b46be99b811aa2592023-11-20T00:39:49ZengMDPI AGNutrients2072-66432020-05-01125143810.3390/nu12051438β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and ExerciseIsabel Gálvez0Leticia Martín-Cordero1María Dolores Hinchado2Eduardo Ortega3Grupo de Investigación en Inmunofisiología, Departamento de Enfermería, Facultad de Medicina, Universidad de Extremadura, 06071 Badajoz, SpainInstituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06071 Badajoz, SpainInstituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06071 Badajoz, SpainInstituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06071 Badajoz, SpainObese individuals present anomalous immune/inflammatory responses with dysregulations in neuroendocrine responses and immune/stress feedback mechanisms. In this context, exercise and β2 adrenergic activation present monocyte-mediated anti-inflammatory effects that are modulated by obesity. However, these anti-inflammatory effects could immunocompromise the monocyte-mediated innate response against a pathogen challenge. Thus, the objective of this work was to evaluate the effect of obesity, and exercise in this condition, on the β2 adrenergic regulation of the phagocytic and microbicide capacity of circulating monocytes. C57BL/6J mice were allocated to different sedentary or exercised, lean or obese groups. Obese mice showed a lower monocyte-mediated innate response than that of lean mice. Globally, selective β2 adrenergic receptor agonist terbutaline decreased the innate response of monocytes from lean and obese sedentary animals, whereas exercise stimulated it. Exercise modulates β2 adrenergic regulation of the innate response in lean and obese animals, with a global stimulatory or neutral effect, thus abolishing the inhibitory effect of terbutaline occurring in sedentary animals. These effects cannot be explained only by changes in the surface expression of toll-like receptors. Therefore, in general, terbutaline does not hinder the effects of regular exercise, but regular exercise does abolish the effects of terbutaline in sedentary individuals.https://www.mdpi.com/2072-6643/12/5/1438β2 adrenergic receptorsterbutalineobesityexercisemonocytesphagocytosis |
| spellingShingle | Isabel Gálvez Leticia Martín-Cordero María Dolores Hinchado Eduardo Ortega β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise Nutrients β2 adrenergic receptors terbutaline obesity exercise monocytes phagocytosis |
| title | β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise |
| title_full | β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise |
| title_fullStr | β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise |
| title_full_unstemmed | β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise |
| title_short | β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise |
| title_sort | β2 adrenergic regulation of the phagocytic and microbicide capacity of circulating monocytes influence of obesity and exercise |
| topic | β2 adrenergic receptors terbutaline obesity exercise monocytes phagocytosis |
| url | https://www.mdpi.com/2072-6643/12/5/1438 |
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