The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus
Objective: Pulmonary system is a target organ for microangiopathic damage in patients with diabetes mellitus (DM). In the present study, the relationships of pulmonary functions with glycemic control, duration of diabetes, and microangiopathic complications have been assessed in type II diabetic pat...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2015-06-01
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| Series: | İstanbul Medical Journal |
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http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-association-of-pulmonary-functions-with-glycem/20974
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| _version_ | 1797918474670964736 |
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| author | Gülay Ulusal Okyay Ezgi Coşkun Yenigün Ahmet Hondur Yıldız Çoruh Çağla Pınar Taştan Uzunmehmetoğlu İsmail Safa Yıldırım |
| author_facet | Gülay Ulusal Okyay Ezgi Coşkun Yenigün Ahmet Hondur Yıldız Çoruh Çağla Pınar Taştan Uzunmehmetoğlu İsmail Safa Yıldırım |
| author_sort | Gülay Ulusal Okyay |
| collection | DOAJ |
| description | Objective: Pulmonary system is a target organ for microangiopathic damage in patients with diabetes mellitus (DM). In the present study, the relationships of pulmonary functions with glycemic control, duration of diabetes, and microangiopathic complications have been assessed in type II diabetic patients.Methods: Thirty-one type II diabetic patients with no history of either smoking or cardiopulmonary diseases were enrolled into the study. Blood tests including glycosylated hemoglobin (HbA1c) were performed. Pulmonary functions were assessed with spirometry and carbon monoxide (CO) diffusion capacity.Results: Pulmonary functions were as follows: FEV1 (%): 93.88±16.12; FVC (%): 86.48±15.76; FEV1/FVC: 94.79±12.34; DLCO (mL/min/mm Hg): 104.13±15.00; and DLVA (mL/min/mmHg/lt): 103.26±13.00. Eleven patients (35.4%) had diabetic nephropathy, 11 patients (35.4%) had retinopathy, 10 patients (32.3%) had sensorimotor neuropathy, and 10 patients (32.3%) did not have any microangiopathic complications. After adjustment for age, gender, and body mass index, there were significant associations between HbA1c and FEV1(p=0.024; r=-0.426), FVC (p=0.009, r=-0.482), and FEV1/FVC ratio (p=0.028, r=0.415). No association was observed between HbA1c and CO diffusion capacity measurements (for all p>0.05). There was no significant relationship between the duration of diabetes and pulmonary functions (for all p>0.05). Pulmonary function tests were found similar between patients having microangiopathic complications and those without them.Conclusion: Poor glycemic control may cause functional alterations of restrictive type in patients with type II DM. |
| first_indexed | 2024-04-10T13:29:49Z |
| format | Article |
| id | doaj.art-3509709be9a04f8f9af3abadf5904ff5 |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T13:29:49Z |
| publishDate | 2015-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-3509709be9a04f8f9af3abadf5904ff52023-02-15T16:11:42ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2015-06-01162485210.5152/imj.2015.3569313049054The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes MellitusGülay Ulusal Okyay0Ezgi Coşkun Yenigün1Ahmet Hondur2Yıldız Çoruh3Çağla Pınar Taştan Uzunmehmetoğlu4İsmail Safa Yıldırım5 Clinic of Internal Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Türkiye Clinic of Internal Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Türkiye Department of Ophtalmology, Gazi University Faculty of Medicine, Ankara, Türkiye Clinic of Neurology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Türkiye Clinic of Chest Disease and Tuberculosis, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Türkiye Clinic of Internal Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Türkiye Objective: Pulmonary system is a target organ for microangiopathic damage in patients with diabetes mellitus (DM). In the present study, the relationships of pulmonary functions with glycemic control, duration of diabetes, and microangiopathic complications have been assessed in type II diabetic patients.Methods: Thirty-one type II diabetic patients with no history of either smoking or cardiopulmonary diseases were enrolled into the study. Blood tests including glycosylated hemoglobin (HbA1c) were performed. Pulmonary functions were assessed with spirometry and carbon monoxide (CO) diffusion capacity.Results: Pulmonary functions were as follows: FEV1 (%): 93.88±16.12; FVC (%): 86.48±15.76; FEV1/FVC: 94.79±12.34; DLCO (mL/min/mm Hg): 104.13±15.00; and DLVA (mL/min/mmHg/lt): 103.26±13.00. Eleven patients (35.4%) had diabetic nephropathy, 11 patients (35.4%) had retinopathy, 10 patients (32.3%) had sensorimotor neuropathy, and 10 patients (32.3%) did not have any microangiopathic complications. After adjustment for age, gender, and body mass index, there were significant associations between HbA1c and FEV1(p=0.024; r=-0.426), FVC (p=0.009, r=-0.482), and FEV1/FVC ratio (p=0.028, r=0.415). No association was observed between HbA1c and CO diffusion capacity measurements (for all p>0.05). There was no significant relationship between the duration of diabetes and pulmonary functions (for all p>0.05). Pulmonary function tests were found similar between patients having microangiopathic complications and those without them.Conclusion: Poor glycemic control may cause functional alterations of restrictive type in patients with type II DM. http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-association-of-pulmonary-functions-with-glycem/20974 Diabetes mellitusglycemic controlmicroangiopathic complicationspulmonary functions |
| spellingShingle | Gülay Ulusal Okyay Ezgi Coşkun Yenigün Ahmet Hondur Yıldız Çoruh Çağla Pınar Taştan Uzunmehmetoğlu İsmail Safa Yıldırım The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus İstanbul Medical Journal Diabetes mellitus glycemic control microangiopathic complications pulmonary functions |
| title | The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus |
| title_full | The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus |
| title_fullStr | The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus |
| title_full_unstemmed | The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus |
| title_short | The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus |
| title_sort | association of pulmonary functions with glycemic control and microvascular complications in patients with type ii diabetes mellitus |
| topic | Diabetes mellitus glycemic control microangiopathic complications pulmonary functions |
| url |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-association-of-pulmonary-functions-with-glycem/20974
|
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