Neuro-ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertension
Abstract Background Idiopathic intracranial hypertension (IIH) is a disorder of unidentified etiology characterized by raised intracranial pressure (ICP) without clinical, laboratory, or radiological evidence of intracranial pathology. The aim of this work was to determine the visual outcome in newl...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-05-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
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| Online Access: | http://link.springer.com/article/10.1186/s41983-019-0081-z |
| _version_ | 1818505911199596544 |
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| author | Wafik Said Bahnasy Yasser Abo Elfotoh El-Heneedy Mahmoud Ebrahim Mostafa Elhassanien Amr Fawzy Sharaf Hagar Ahmed Khalid |
| author_facet | Wafik Said Bahnasy Yasser Abo Elfotoh El-Heneedy Mahmoud Ebrahim Mostafa Elhassanien Amr Fawzy Sharaf Hagar Ahmed Khalid |
| author_sort | Wafik Said Bahnasy |
| collection | DOAJ |
| description | Abstract Background Idiopathic intracranial hypertension (IIH) is a disorder of unidentified etiology characterized by raised intracranial pressure (ICP) without clinical, laboratory, or radiological evidence of intracranial pathology. The aim of this work was to determine the visual outcome in newly diagnosed IIH patients. Methods The study included 68 IIH patients; 59 responded to medical treatment and nine needed lumboperitoneal shunting (LPS). Patients were submitted to papilledema grading using Frisén Scale, water CSF manometry, brain MRI/MRV, mean deviation of visual field examination (MD-VFE), optic nerve sheath diameter (ONSD), average optic disc optical coherence tomography–retinal nerve fiber layer (OCT–RNFL) thickness, and pattern–reversal visual evoked potential (VEP). Results Patients needed LPS showed statistically significant increase in baseline papilledema grade, MD-VFE, ONSD, average OCT–RNFL thickness, and P100 VEP latency. On the other hand, both studied groups showed statistically non-significant differences regarding the patients’ ages and opening CSF pressure. Conclusion Newly diagnosed IIH patients’ evaluation must be based on multimodality neuro-ophthalmological assessment where papilledema grade, MD-VFE, and OCT–RNFL are valuable biomarkers of PVD while P100 VEP latency delay is a predictor of poor visual outcome and ONSD is an early indicator of elevated ICP regression after LPS surgery. |
| first_indexed | 2024-12-10T21:57:18Z |
| format | Article |
| id | doaj.art-350a25b7f1084a58a42571d2208aa21d |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-10T21:57:18Z |
| publishDate | 2019-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-350a25b7f1084a58a42571d2208aa21d2022-12-22T01:32:00ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292019-05-015511810.1186/s41983-019-0081-zNeuro-ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertensionWafik Said Bahnasy0Yasser Abo Elfotoh El-Heneedy1Mahmoud Ebrahim Mostafa Elhassanien2Amr Fawzy Sharaf3Hagar Ahmed Khalid4Department of Neuropsychiatry, Faculty of Medicine, Tanta UniversityDepartment of Neuropsychiatry, Faculty of Medicine, Tanta UniversityDepartment of Neuropsychiatry, Faculty of Medicine, Tanta UniversityDepartment of Neuropsychiatry, Faculty of Medicine, Tanta UniversityDepartment of Neuropsychiatry, Faculty of Medicine, Tanta UniversityAbstract Background Idiopathic intracranial hypertension (IIH) is a disorder of unidentified etiology characterized by raised intracranial pressure (ICP) without clinical, laboratory, or radiological evidence of intracranial pathology. The aim of this work was to determine the visual outcome in newly diagnosed IIH patients. Methods The study included 68 IIH patients; 59 responded to medical treatment and nine needed lumboperitoneal shunting (LPS). Patients were submitted to papilledema grading using Frisén Scale, water CSF manometry, brain MRI/MRV, mean deviation of visual field examination (MD-VFE), optic nerve sheath diameter (ONSD), average optic disc optical coherence tomography–retinal nerve fiber layer (OCT–RNFL) thickness, and pattern–reversal visual evoked potential (VEP). Results Patients needed LPS showed statistically significant increase in baseline papilledema grade, MD-VFE, ONSD, average OCT–RNFL thickness, and P100 VEP latency. On the other hand, both studied groups showed statistically non-significant differences regarding the patients’ ages and opening CSF pressure. Conclusion Newly diagnosed IIH patients’ evaluation must be based on multimodality neuro-ophthalmological assessment where papilledema grade, MD-VFE, and OCT–RNFL are valuable biomarkers of PVD while P100 VEP latency delay is a predictor of poor visual outcome and ONSD is an early indicator of elevated ICP regression after LPS surgery.http://link.springer.com/article/10.1186/s41983-019-0081-zIdiopathic intracranial hypertensionPapilledemaAutomated perimetryOptic nerve sheath diameterOptical coherence tomographyVisual evoked potential |
| spellingShingle | Wafik Said Bahnasy Yasser Abo Elfotoh El-Heneedy Mahmoud Ebrahim Mostafa Elhassanien Amr Fawzy Sharaf Hagar Ahmed Khalid Neuro-ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertension The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Idiopathic intracranial hypertension Papilledema Automated perimetry Optic nerve sheath diameter Optical coherence tomography Visual evoked potential |
| title | Neuro-ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertension |
| title_full | Neuro-ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertension |
| title_fullStr | Neuro-ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertension |
| title_full_unstemmed | Neuro-ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertension |
| title_short | Neuro-ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertension |
| title_sort | neuro ophthalmological biomarkers of visual outcome in newly diagnosed idiopathic intracranial hypertension |
| topic | Idiopathic intracranial hypertension Papilledema Automated perimetry Optic nerve sheath diameter Optical coherence tomography Visual evoked potential |
| url | http://link.springer.com/article/10.1186/s41983-019-0081-z |
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