Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate
This study aims to enhance the targeted delivery of a powerful antioxidant, ferulate (FA), by developing a controlled release formulation (CRF) based on the incorporation of layered double hydroxide and Tween-80 polymeric surfactant. The layered double hydroxide-ferulate (LDH-FA) synthesized by co-p...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2024-04-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://journal.ugm.ac.id/ijc/article/view/91497 |
| _version_ | 1797232803284254720 |
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| author | Sharifah Norain Mohd Sharif Norhayati Hashim Illyas Md Isa Maizatul Najwa Jajuli Afif Arifin Norlaili Abu Bakar Mazidah Mamat Suyanta Suyanta |
| author_facet | Sharifah Norain Mohd Sharif Norhayati Hashim Illyas Md Isa Maizatul Najwa Jajuli Afif Arifin Norlaili Abu Bakar Mazidah Mamat Suyanta Suyanta |
| author_sort | Sharifah Norain Mohd Sharif |
| collection | DOAJ |
| description | This study aims to enhance the targeted delivery of a powerful antioxidant, ferulate (FA), by developing a controlled release formulation (CRF) based on the incorporation of layered double hydroxide and Tween-80 polymeric surfactant. The layered double hydroxide-ferulate (LDH-FA) synthesized by co-precipitation method was homogenously mixed with the Tween-80 coater under continuous stirring. The successful Tween-80 coating was verified with PXRD analysis and supported by FTIR. No changes in interlayer distance between LDH-FA (at 17.4 and 8.7 Å) and LDH-FA-T80 (at 17.6 and 8.6 Å) were observed in the PXRD pattern. TGA/DTG analysis demonstrated good thermal stability of LDH-FA-T80, with the ability to withstand extreme temperatures up to 460 °C. The association of Tween-80 with LDH-FA progressively sustained the release time of FA in each aqueous solution, with a release time of up to 440 min. For both LDH-FA and LDH-FA-T80, the release of FA is through dissolution and anion exchange release mechanism (regulated by pseudo-second-order kinetic model). The study's findings suggest practical applications of FA in the pharmaceutical industry by implying the retarding effect triggered by Tween-80, offering new insights for the application of CRF to enhance the therapeutic effect of FA. |
| first_indexed | 2024-04-24T16:06:05Z |
| format | Article |
| id | doaj.art-350ab5f72b354f0385d14e74946d1933 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-04-24T16:06:05Z |
| publishDate | 2024-04-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-350ab5f72b354f0385d14e74946d19332024-04-01T04:11:25ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782024-04-0124254355910.22146/ijc.9149735410Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-FerulateSharifah Norain Mohd Sharif0Norhayati Hashim1Illyas Md Isa2Maizatul Najwa Jajuli3Afif Arifin4Norlaili Abu Bakar5Mazidah Mamat6Suyanta Suyanta7Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, Malaysia; Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, MalaysiaDepartment of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, Malaysia; Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, MalaysiaDepartment of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, Malaysia; Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, MalaysiaDepartment of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, Malaysia; Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, MalaysiaTamhidi Centre, Universiti Sains Islam Malaysia, Bandar Baru Nilai, Nilai 71800, MalaysiaDepartment of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim 35900, MalaysiaSchool of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu 21030, MalaysiaDepartment of Chemistry Education, Faculty of Mathematics and Natural Sciences, Yogyakarta State University, Yogyakarta 55281, IndonesiaThis study aims to enhance the targeted delivery of a powerful antioxidant, ferulate (FA), by developing a controlled release formulation (CRF) based on the incorporation of layered double hydroxide and Tween-80 polymeric surfactant. The layered double hydroxide-ferulate (LDH-FA) synthesized by co-precipitation method was homogenously mixed with the Tween-80 coater under continuous stirring. The successful Tween-80 coating was verified with PXRD analysis and supported by FTIR. No changes in interlayer distance between LDH-FA (at 17.4 and 8.7 Å) and LDH-FA-T80 (at 17.6 and 8.6 Å) were observed in the PXRD pattern. TGA/DTG analysis demonstrated good thermal stability of LDH-FA-T80, with the ability to withstand extreme temperatures up to 460 °C. The association of Tween-80 with LDH-FA progressively sustained the release time of FA in each aqueous solution, with a release time of up to 440 min. For both LDH-FA and LDH-FA-T80, the release of FA is through dissolution and anion exchange release mechanism (regulated by pseudo-second-order kinetic model). The study's findings suggest practical applications of FA in the pharmaceutical industry by implying the retarding effect triggered by Tween-80, offering new insights for the application of CRF to enhance the therapeutic effect of FA.https://journal.ugm.ac.id/ijc/article/view/91497controlled release formulationlayered double hydroxidetween-80, ferulateintercalation |
| spellingShingle | Sharifah Norain Mohd Sharif Norhayati Hashim Illyas Md Isa Maizatul Najwa Jajuli Afif Arifin Norlaili Abu Bakar Mazidah Mamat Suyanta Suyanta Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate Indonesian Journal of Chemistry controlled release formulation layered double hydroxide tween-80, ferulate intercalation |
| title | Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate |
| title_full | Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate |
| title_fullStr | Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate |
| title_full_unstemmed | Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate |
| title_short | Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate |
| title_sort | tween 80 coating in enhancing physicochemical stability kinetics and release mechanism of layered double hydroxide ferulate |
| topic | controlled release formulation layered double hydroxide tween-80, ferulate intercalation |
| url | https://journal.ugm.ac.id/ijc/article/view/91497 |
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