Alternative blood transfusion triggers: a narrative review
Abstract Background Anemia, characterized by low hemoglobin levels, is a global public health concern. Anemia is an independent factor worsening outcomes in various patient groups. Blood transfusion has been the traditional treatment for anemia; its triggers, primarily based on hemoglobin levels; ho...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12871-024-02447-3 |
| _version_ | 1797273453383909376 |
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| author | Ardak Arynov Dilyara Kaidarova Barbara Kabon |
| author_facet | Ardak Arynov Dilyara Kaidarova Barbara Kabon |
| author_sort | Ardak Arynov |
| collection | DOAJ |
| description | Abstract Background Anemia, characterized by low hemoglobin levels, is a global public health concern. Anemia is an independent factor worsening outcomes in various patient groups. Blood transfusion has been the traditional treatment for anemia; its triggers, primarily based on hemoglobin levels; however, hemoglobin level is not always an ideal trigger for blood transfusion. Additionally, blood transfusion worsens clinical outcomes in certain patient groups. This narrative review explores alternative triggers for red blood cell transfusion and their physiological basis. Main Text The review delves into the physiology of oxygen transport and highlights the limitations of using hemoglobin levels alone as transfusion trigger. The main aim of blood transfusion is to optimize oxygen delivery, necessitating an individualized approach based on clinical signs of anemia and the balance between oxygen delivery and consumption, reflected by the oxygen extraction rate. The narrative review covers different alternative triggers. It presents insights into their diagnostic value and clinical applications, emphasizing the need for personalized transfusion strategies. Conclusion Anemia and blood transfusion are significant factors affecting patient outcomes. While restrictive transfusion strategies are widely recommended, they may not account for the nuances of specific patient populations. The search for alternative transfusion triggers is essential to tailor transfusion therapy effectively, especially in patients with comorbidities or unique clinical profiles. Investigating alternative triggers not only enhances patient care by identifying more precise indicators but also minimizes transfusion-related risks, optimizes blood product utilization, and ensures availability when needed. Personalized transfusion strategies based on alternative triggers hold the potential to improve outcomes in various clinical scenarios, addressing anemia’s complex challenges in healthcare. Further research and evidence are needed to refine these alternative triggers and guide their implementation in clinical practice. |
| first_indexed | 2024-03-07T14:44:28Z |
| format | Article |
| id | doaj.art-350b38d95a5648c3b1a08c1ade5862a4 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-03-07T14:44:28Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-350b38d95a5648c3b1a08c1ade5862a42024-03-05T20:05:02ZengBMCBMC Anesthesiology1471-22532024-02-0124111210.1186/s12871-024-02447-3Alternative blood transfusion triggers: a narrative reviewArdak Arynov0Dilyara Kaidarova1Barbara Kabon2Department of Anesthesiology and Intensive Care, Kazakh Institute of Oncology and RadiologyKazakh Institute of Oncology and RadiologyDepartment of Anaesthesia, General Intensive Medicine and Pain Medicine Medical, University of ViennaAbstract Background Anemia, characterized by low hemoglobin levels, is a global public health concern. Anemia is an independent factor worsening outcomes in various patient groups. Blood transfusion has been the traditional treatment for anemia; its triggers, primarily based on hemoglobin levels; however, hemoglobin level is not always an ideal trigger for blood transfusion. Additionally, blood transfusion worsens clinical outcomes in certain patient groups. This narrative review explores alternative triggers for red blood cell transfusion and their physiological basis. Main Text The review delves into the physiology of oxygen transport and highlights the limitations of using hemoglobin levels alone as transfusion trigger. The main aim of blood transfusion is to optimize oxygen delivery, necessitating an individualized approach based on clinical signs of anemia and the balance between oxygen delivery and consumption, reflected by the oxygen extraction rate. The narrative review covers different alternative triggers. It presents insights into their diagnostic value and clinical applications, emphasizing the need for personalized transfusion strategies. Conclusion Anemia and blood transfusion are significant factors affecting patient outcomes. While restrictive transfusion strategies are widely recommended, they may not account for the nuances of specific patient populations. The search for alternative transfusion triggers is essential to tailor transfusion therapy effectively, especially in patients with comorbidities or unique clinical profiles. Investigating alternative triggers not only enhances patient care by identifying more precise indicators but also minimizes transfusion-related risks, optimizes blood product utilization, and ensures availability when needed. Personalized transfusion strategies based on alternative triggers hold the potential to improve outcomes in various clinical scenarios, addressing anemia’s complex challenges in healthcare. Further research and evidence are needed to refine these alternative triggers and guide their implementation in clinical practice.https://doi.org/10.1186/s12871-024-02447-3AnemiaBlood transfusionTransfusion triggersOxygen deliveryOxygen consumption |
| spellingShingle | Ardak Arynov Dilyara Kaidarova Barbara Kabon Alternative blood transfusion triggers: a narrative review BMC Anesthesiology Anemia Blood transfusion Transfusion triggers Oxygen delivery Oxygen consumption |
| title | Alternative blood transfusion triggers: a narrative review |
| title_full | Alternative blood transfusion triggers: a narrative review |
| title_fullStr | Alternative blood transfusion triggers: a narrative review |
| title_full_unstemmed | Alternative blood transfusion triggers: a narrative review |
| title_short | Alternative blood transfusion triggers: a narrative review |
| title_sort | alternative blood transfusion triggers a narrative review |
| topic | Anemia Blood transfusion Transfusion triggers Oxygen delivery Oxygen consumption |
| url | https://doi.org/10.1186/s12871-024-02447-3 |
| work_keys_str_mv | AT ardakarynov alternativebloodtransfusiontriggersanarrativereview AT dilyarakaidarova alternativebloodtransfusiontriggersanarrativereview AT barbarakabon alternativebloodtransfusiontriggersanarrativereview |