Optimal Paths Between Parameter Estimates in Non-linear ODE Systems Using the Nudged Elastic Band Method

Optimal Paths Between Parameter Estimates in Non-linear ODE Systems Using the Nudged Elastic Band Method

Ordinary differential equation (ODE) models are frequently used to mathematically represent the dynamic behavior of cellular components, e.g., for describing biochemical reaction networks. Solutions of these ODE models depend non-linearly on parameters, which can be estimated using experimental data...

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Bibliographic Details
Main Authors: Christian Tönsing, Jens Timmer, Clemens Kreutz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physics
Subjects:
ODE models
parameter estimation
optimization
optimal paths
nudged elastic band
systems biology
Online Access:https://www.frontiersin.org/article/10.3389/fphy.2019.00149/full

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