Comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type II diabetes
Introduction: Type 2 diabetes is the most common metabolic diseases in developed and developing countries with no effective treatment options. This study purpose was to compare different regimens of oral anti-diabetic therapy effects on the type 2 diabetic patients while fasting during Ramadan. Meth...
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| Format: | Article |
| Language: | English |
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Negah Institute for Scientific Communication
2018-04-01
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| Series: | International Journal of Biomedicine and Public Health |
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| Online Access: | http://www.ijbmph.com/article_61057_e131a1a08e565475e7922137717c538a.pdf |
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| author | Mernoosh Zakerkish Hajiyeh Bibi Shahbaziyan Majid Karandish Homira Rashidi Seyed Peyman Payami |
| author_facet | Mernoosh Zakerkish Hajiyeh Bibi Shahbaziyan Majid Karandish Homira Rashidi Seyed Peyman Payami |
| author_sort | Mernoosh Zakerkish |
| collection | DOAJ |
| description | Introduction: Type 2 diabetes is the most common metabolic diseases in developed and developing countries with no effective treatment options. This study purpose was to compare different regimens of oral anti-diabetic therapy effects on the type 2 diabetic patients while fasting during Ramadan. Methods: In the double-blind controlled trial 90 patients with type 2 diabetes were divided randomly into three groups: 30 patients continued the previous dose of sulfonylurea (Group 1), 30 participants received a dose which was 25% lower than the previous sulfonylurea dose (group 2), and in the last 30 patients, repaglinide was replaced sulfonylurea (Group 3). Glucose, glycosylated hemoglobin (HbA1C), fructosamine, total cholesterol, low-density lipoprotein (LDL), high density lipoprotein (HDL), and triglycerides levels were measured in all participants before and after Ramadan. The weight and BMI were also controlled. Results: In all intervention groups a significant decreasing was seen in the body weight, BMI, fructoseamine, total cholesterol, and LDL; and also, a significant increasing was seen in HDL. The hypoglycemia incidence was significantly lower in Group 3 than Group 1. The results in fructosamine reduction and HDL cholesterol increasing were significantly better in Group 3 compared to Group 2 (P<0.05). Significant changes were not seen in total cholesterol, LDL, triglyceride, FBS, and HbA1C levels among the three treatment groups during Ramadan. Conclusion: The repaglinide consumption in comparing with sulfonylurea in patients with diabetes during Ramadan can cause fewer hypoglycemia, and better glycemic, and lipid control. |
| first_indexed | 2024-12-14T07:36:02Z |
| format | Article |
| id | doaj.art-350e13c8d98947d7a2a78c7096eb4add |
| institution | Directory Open Access Journal |
| issn | 2588-5375 2588-5375 |
| language | English |
| last_indexed | 2024-12-14T07:36:02Z |
| publishDate | 2018-04-01 |
| publisher | Negah Institute for Scientific Communication |
| record_format | Article |
| series | International Journal of Biomedicine and Public Health |
| spelling | doaj.art-350e13c8d98947d7a2a78c7096eb4add2022-12-21T23:11:11ZengNegah Institute for Scientific CommunicationInternational Journal of Biomedicine and Public Health2588-53752588-53752018-04-0112596610.22631/ijbmph.2018.118140.102061057Comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type II diabetesMernoosh Zakerkish0Hajiyeh Bibi Shahbaziyan1Majid Karandish2Homira Rashidi3Seyed Peyman Payami4Department of Endocrinology, Health Research Institution, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Endocrinology, Diabetes Research Center,Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Nutrition, Faculty of Paramedicine, Diabetes Research Center,Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Endocrinology, Diabetes Research Center,Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Endocrinology, Diabetes Research Center,Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Introduction: Type 2 diabetes is the most common metabolic diseases in developed and developing countries with no effective treatment options. This study purpose was to compare different regimens of oral anti-diabetic therapy effects on the type 2 diabetic patients while fasting during Ramadan. Methods: In the double-blind controlled trial 90 patients with type 2 diabetes were divided randomly into three groups: 30 patients continued the previous dose of sulfonylurea (Group 1), 30 participants received a dose which was 25% lower than the previous sulfonylurea dose (group 2), and in the last 30 patients, repaglinide was replaced sulfonylurea (Group 3). Glucose, glycosylated hemoglobin (HbA1C), fructosamine, total cholesterol, low-density lipoprotein (LDL), high density lipoprotein (HDL), and triglycerides levels were measured in all participants before and after Ramadan. The weight and BMI were also controlled. Results: In all intervention groups a significant decreasing was seen in the body weight, BMI, fructoseamine, total cholesterol, and LDL; and also, a significant increasing was seen in HDL. The hypoglycemia incidence was significantly lower in Group 3 than Group 1. The results in fructosamine reduction and HDL cholesterol increasing were significantly better in Group 3 compared to Group 2 (P<0.05). Significant changes were not seen in total cholesterol, LDL, triglyceride, FBS, and HbA1C levels among the three treatment groups during Ramadan. Conclusion: The repaglinide consumption in comparing with sulfonylurea in patients with diabetes during Ramadan can cause fewer hypoglycemia, and better glycemic, and lipid control.http://www.ijbmph.com/article_61057_e131a1a08e565475e7922137717c538a.pdfhypoglycemiametforminrepaglinidesulfonylureatype ii diabetes |
| spellingShingle | Mernoosh Zakerkish Hajiyeh Bibi Shahbaziyan Majid Karandish Homira Rashidi Seyed Peyman Payami Comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type II diabetes International Journal of Biomedicine and Public Health hypoglycemia metformin repaglinide sulfonylurea type ii diabetes |
| title | Comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type II diabetes |
| title_full | Comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type II diabetes |
| title_fullStr | Comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type II diabetes |
| title_full_unstemmed | Comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type II diabetes |
| title_short | Comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type II diabetes |
| title_sort | comparison of the effectiveness of different oral glucose lowering drugs in fasting patients with type ii diabetes |
| topic | hypoglycemia metformin repaglinide sulfonylurea type ii diabetes |
| url | http://www.ijbmph.com/article_61057_e131a1a08e565475e7922137717c538a.pdf |
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