ItaLynch: an ongoing Italian study to evaluate the feasibility of mainstreaming the diagnosis of Lynch syndrome in colorectal cancer patients

ItaLynch: an ongoing Italian study to evaluate the feasibility of mainstreaming the diagnosis of Lynch syndrome in colorectal cancer patients

Background: International guidelines recommend universal screening for Lynch syndrome (LS) through somatic DNA mismatch repair deficiency (dMMR) testing in all colorectal cancers (CRCs). However, LS remains largely underdiagnosed. Mainstreaming LS diagnosis through oncologist-driven genetic testing...

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Main Authors: A. Puccini, F. Grillo, M. Fassan, S. Lonardi, M. Genuardi, R. Cannizzaro, G.M. Cavestro, F. Marmorino, V. Conca, L. Salvatore, F. Bergamo, F. Tosi, F. Morano, V. Daprà, C. Molica, D. Barana, A. Guglielmi, C. Signorelli, M. D’Amico, F. Zoratto, D. Iacono, A. Morabito, G. Martini, A. Fabbroncini, M. Duro, G. Bruera, A. Auriemma, B. Bonanni, A. Percesepe, M. Dono, L. Battistuzzi, R. Labianca, L. Boni, S. Sciallero
פורמט: Article
שפה:English
יצא לאור: Elsevier 2024-03-01
סדרה:ESMO Gastrointestinal Oncology
נושאים:
DNA mismatch repair deficiency
colorectal cancer
Lynch syndrome
universal screening
reflex testing
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2949819824000050

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http://www.sciencedirect.com/science/article/pii/S2949819824000050

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