Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights
Osteoarthritis (OA) is a chronic arthritic disease characterized by cartilage degradation, synovial inflammation, and subchondral bone lesions. The studies on the pathogenesis of OA are complex and diverse. The roles of receptors signaling in chondrocyte anabolism, inflammatory factors expression of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-07-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0075 |
| _version_ | 1797998097070030848 |
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| author | Lei Li Meng Li Changqing Xu Chen Zhu Gang Yao Shiyuan Fang |
| author_facet | Lei Li Meng Li Changqing Xu Chen Zhu Gang Yao Shiyuan Fang |
| author_sort | Lei Li |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a chronic arthritic disease characterized by cartilage degradation, synovial inflammation, and subchondral bone lesions. The studies on the pathogenesis of OA are complex and diverse. The roles of receptors signaling in chondrocyte anabolism, inflammatory factors expression of synovial fibroblast, and angiogenesis in subchondral bone are particularly important for exploring the pathological mechanism of OA and clinical diagnosis and treatment. By reviewing the relevant literature, this article elaborates on the abnormal expression of receptors and the signaling transduction pathways from different pathological changes of OA anatomical components, aiming to provide new research ideas and clinical therapeutic value for OA pathogenesis. |
| first_indexed | 2024-04-11T10:43:06Z |
| format | Article |
| id | doaj.art-35140ef4f5ae465ab8049c2c65e12016 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-11T10:43:06Z |
| publishDate | 2022-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-35140ef4f5ae465ab8049c2c65e120162022-12-22T04:29:08ZengDe GruyterOpen Life Sciences2391-54122022-07-0117169570910.1515/biol-2022-0075Effect of cell receptors in the pathogenesis of osteoarthritis: Current insightsLei Li0Meng Li1Changqing Xu2Chen Zhu3Gang Yao4Shiyuan Fang5Department of Orthopaedics, The First Affiliated Hospital of University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui, ChinaDepartment of Orthopaedics, Dongxihu District People’s Hospital Affiliated to Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui, ChinaOsteoarthritis (OA) is a chronic arthritic disease characterized by cartilage degradation, synovial inflammation, and subchondral bone lesions. The studies on the pathogenesis of OA are complex and diverse. The roles of receptors signaling in chondrocyte anabolism, inflammatory factors expression of synovial fibroblast, and angiogenesis in subchondral bone are particularly important for exploring the pathological mechanism of OA and clinical diagnosis and treatment. By reviewing the relevant literature, this article elaborates on the abnormal expression of receptors and the signaling transduction pathways from different pathological changes of OA anatomical components, aiming to provide new research ideas and clinical therapeutic value for OA pathogenesis.https://doi.org/10.1515/biol-2022-0075receptorosteoarthritiscartilagesynoviumsubchondral bone |
| spellingShingle | Lei Li Meng Li Changqing Xu Chen Zhu Gang Yao Shiyuan Fang Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights Open Life Sciences receptor osteoarthritis cartilage synovium subchondral bone |
| title | Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights |
| title_full | Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights |
| title_fullStr | Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights |
| title_full_unstemmed | Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights |
| title_short | Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights |
| title_sort | effect of cell receptors in the pathogenesis of osteoarthritis current insights |
| topic | receptor osteoarthritis cartilage synovium subchondral bone |
| url | https://doi.org/10.1515/biol-2022-0075 |
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