Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications
Our early life nutritional environment can influence several aspects of physiology, including our propensity to become obese. There is now evidence to suggest perinatal diet can also independently influence development of our innate immune system. This review will address three not-necessarily-exclu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00144/full |
| _version_ | 1818921110287155200 |
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| author | Sarah J Spencer |
| author_facet | Sarah J Spencer |
| author_sort | Sarah J Spencer |
| collection | DOAJ |
| description | Our early life nutritional environment can influence several aspects of physiology, including our propensity to become obese. There is now evidence to suggest perinatal diet can also independently influence development of our innate immune system. This review will address three not-necessarily-exclusive mechanisms by which perinatal nutrition can program neuroimmune function long-term: by predisposing the individual to obesity, by altering the gut microbiota, and by inducing epigenetic modifications that alter gene transcription throughout life. |
| first_indexed | 2024-12-20T01:32:26Z |
| format | Article |
| id | doaj.art-3518a482c701445e8ef4cd50de1bb72a |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T01:32:26Z |
| publishDate | 2013-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-3518a482c701445e8ef4cd50de1bb72a2022-12-21T19:58:05ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2013-08-01710.3389/fnins.2013.0014447983Perinatal nutrition programs neuroimmune function long-term: mechanisms and implicationsSarah J Spencer0RMIT UniversityOur early life nutritional environment can influence several aspects of physiology, including our propensity to become obese. There is now evidence to suggest perinatal diet can also independently influence development of our innate immune system. This review will address three not-necessarily-exclusive mechanisms by which perinatal nutrition can program neuroimmune function long-term: by predisposing the individual to obesity, by altering the gut microbiota, and by inducing epigenetic modifications that alter gene transcription throughout life.http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00144/fullObesityepigeneticsGut MicrobiotaHypothalamic-Pituitary-Adrenal Axisglucorticoids |
| spellingShingle | Sarah J Spencer Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications Frontiers in Neuroscience Obesity epigenetics Gut Microbiota Hypothalamic-Pituitary-Adrenal Axis glucorticoids |
| title | Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications |
| title_full | Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications |
| title_fullStr | Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications |
| title_full_unstemmed | Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications |
| title_short | Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications |
| title_sort | perinatal nutrition programs neuroimmune function long term mechanisms and implications |
| topic | Obesity epigenetics Gut Microbiota Hypothalamic-Pituitary-Adrenal Axis glucorticoids |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00144/full |
| work_keys_str_mv | AT sarahjspencer perinatalnutritionprogramsneuroimmunefunctionlongtermmechanismsandimplications |