A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

ABSTRACT Coronaviruses (CoVs) encode nonstructural proteins 1–16 (nsps 1–16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis. RDV resistance mutations have been reported only in the nonstruc...

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Bibliographic Details
Main Authors: Samantha L. Grimes, Young J. Choi, Anoosha Banerjee, Gabriel Small, Jordan Anderson-Daniels, Jennifer Gribble, Andrea J. Pruijssers, Maria L. Agostini, Alexandra Abu-Shmais, Xiaotao Lu, Seth A. Darst, Elizabeth Campbell, Mark R. Denison
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
coronavirus
murine hepatitis virus (MHV)
SARS-CoV-2
nsp13
helicase
remdesivir
Online Access:https://journals.asm.org/doi/10.1128/mbio.01060-23

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