Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
<p>The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2011-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v07p0762.htm |
| _version_ | 1818020835382788096 |
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| author | Yu Nie, Bian-Mei Han, Xue-Bin Liu, Jin-Jing Yang, Fang Wang, Xiang-Feng Cong, Xi Chen |
| author_facet | Yu Nie, Bian-Mei Han, Xue-Bin Liu, Jin-Jing Yang, Fang Wang, Xiang-Feng Cong, Xi Chen |
| author_sort | Yu Nie, Bian-Mei Han, Xue-Bin Liu, Jin-Jing Yang, Fang Wang, Xiang-Feng Cong, Xi Chen |
| collection | DOAJ |
| description | <p>The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD.</p> |
| first_indexed | 2024-04-14T08:10:45Z |
| format | Article |
| id | doaj.art-351f6dc18bac47998c3d53cf0716de13 |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-04-14T08:10:45Z |
| publishDate | 2011-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-351f6dc18bac47998c3d53cf0716de132022-12-22T02:04:34ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882011-01-0176762768Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem CellsYu Nie, Bian-Mei Han, Xue-Bin Liu, Jin-Jing Yang, Fang Wang, Xiang-Feng Cong, Xi Chen<p>The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD.</p>http://www.biolsci.org/v07p0762.htm |
| spellingShingle | Yu Nie, Bian-Mei Han, Xue-Bin Liu, Jin-Jing Yang, Fang Wang, Xiang-Feng Cong, Xi Chen Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells International Journal of Biological Sciences |
| title | Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells |
| title_full | Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells |
| title_fullStr | Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells |
| title_full_unstemmed | Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells |
| title_short | Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells |
| title_sort | identification of micrornas involved in hypoxia and serum deprivation induced apoptosis in mesenchymal stem cells |
| url | http://www.biolsci.org/v07p0762.htm |
| work_keys_str_mv | AT yuniebianmeihanxuebinliujinjingyangfangwangxiangfengcongxichen identificationofmicrornasinvolvedinhypoxiaandserumdeprivationinducedapoptosisinmesenchymalstemcells |