Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases
Highlights Accumulating evidences show that the alterations in the gut microbiota associated to metabolic diseases are different in men and women, and these differences may influence sex differences in the development and prevalence of metabolic diseases. The key aspects involved in these pathologie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-023-00490-2 |
| _version_ | 1811166050093367296 |
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| author | Jose Antonio Santos-Marcos Marina Mora-Ortiz Manuel Tena-Sempere Jose Lopez-Miranda Antonio Camargo |
| author_facet | Jose Antonio Santos-Marcos Marina Mora-Ortiz Manuel Tena-Sempere Jose Lopez-Miranda Antonio Camargo |
| author_sort | Jose Antonio Santos-Marcos |
| collection | DOAJ |
| description | Highlights Accumulating evidences show that the alterations in the gut microbiota associated to metabolic diseases are different in men and women, and these differences may influence sex differences in the development and prevalence of metabolic diseases. The key aspects involved in these pathologies include lipopolysaccharide-inflammation, gut barrier integrity, gut microbiota-derived metabolites and gut–brain axis. Sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in the sexual dimorphism of gut microbiota. The influence of sex hormones is reflected both in men and women, and among women themselves due to hormonal changes associated with the menopause. The interaction between sex steroids and the gut microbiota plays a prominent role in the development of metabolic diseases. |
| first_indexed | 2024-04-10T15:47:13Z |
| format | Article |
| id | doaj.art-351f746fa12f4b5db6a8ade23e924183 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-10T15:47:13Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-351f746fa12f4b5db6a8ade23e9241832023-02-12T12:02:33ZengBMCBiology of Sex Differences2042-64102023-02-0114112410.1186/s13293-023-00490-2Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseasesJose Antonio Santos-Marcos0Marina Mora-Ortiz1Manuel Tena-Sempere2Jose Lopez-Miranda3Antonio Camargo4Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofia University HospitalLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofia University HospitalMaimónides Biomedical Research Institute of Córdoba (IMIBIC)Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofia University HospitalLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofia University HospitalHighlights Accumulating evidences show that the alterations in the gut microbiota associated to metabolic diseases are different in men and women, and these differences may influence sex differences in the development and prevalence of metabolic diseases. The key aspects involved in these pathologies include lipopolysaccharide-inflammation, gut barrier integrity, gut microbiota-derived metabolites and gut–brain axis. Sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in the sexual dimorphism of gut microbiota. The influence of sex hormones is reflected both in men and women, and among women themselves due to hormonal changes associated with the menopause. The interaction between sex steroids and the gut microbiota plays a prominent role in the development of metabolic diseases.https://doi.org/10.1186/s13293-023-00490-2Gut microbiotaSex steroidsSex differencesObesityMetabolic syndromeType 2 diabetes |
| spellingShingle | Jose Antonio Santos-Marcos Marina Mora-Ortiz Manuel Tena-Sempere Jose Lopez-Miranda Antonio Camargo Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases Biology of Sex Differences Gut microbiota Sex steroids Sex differences Obesity Metabolic syndrome Type 2 diabetes |
| title | Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases |
| title_full | Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases |
| title_fullStr | Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases |
| title_full_unstemmed | Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases |
| title_short | Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases |
| title_sort | interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases |
| topic | Gut microbiota Sex steroids Sex differences Obesity Metabolic syndrome Type 2 diabetes |
| url | https://doi.org/10.1186/s13293-023-00490-2 |
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