Metabolites: a converging node of host and microbe to explain meta-organism
Meta-organisms encompassing the host and resident microbiota play a significant role in combatting diseases and responding to stress. Hence, there is growing traction to build a knowledge base about this ecosystem, particularly to characterize the bidirectional relationship between the host and micr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1337368/full |
| _version_ | 1797276730993410048 |
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| author | Nabarun Chakraborty |
| author_facet | Nabarun Chakraborty |
| author_sort | Nabarun Chakraborty |
| collection | DOAJ |
| description | Meta-organisms encompassing the host and resident microbiota play a significant role in combatting diseases and responding to stress. Hence, there is growing traction to build a knowledge base about this ecosystem, particularly to characterize the bidirectional relationship between the host and microbiota. In this context, metabolomics has emerged as the major converging node of this entire ecosystem. Systematic comprehension of this resourceful omics component can elucidate the organism-specific response trajectory and the communication grid across the ecosystem embodying meta-organisms. Translating this knowledge into designing nutraceuticals and next-generation therapy are ongoing. Its major hindrance is a significant knowledge gap about the underlying mechanisms maintaining a delicate balance within this ecosystem. To bridge this knowledge gap, a holistic picture of the available information has been presented with a primary focus on the microbiota-metabolite relationship dynamics. The central theme of this article is the gut-brain axis and the participating microbial metabolites that impact cerebral functions. |
| first_indexed | 2024-03-07T15:32:24Z |
| format | Article |
| id | doaj.art-35201981d5644b11a5bb71167715f077 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-07T15:32:24Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-35201981d5644b11a5bb71167715f0772024-03-05T15:47:50ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-03-011510.3389/fmicb.2024.13373681337368Metabolites: a converging node of host and microbe to explain meta-organismNabarun ChakrabortyMeta-organisms encompassing the host and resident microbiota play a significant role in combatting diseases and responding to stress. Hence, there is growing traction to build a knowledge base about this ecosystem, particularly to characterize the bidirectional relationship between the host and microbiota. In this context, metabolomics has emerged as the major converging node of this entire ecosystem. Systematic comprehension of this resourceful omics component can elucidate the organism-specific response trajectory and the communication grid across the ecosystem embodying meta-organisms. Translating this knowledge into designing nutraceuticals and next-generation therapy are ongoing. Its major hindrance is a significant knowledge gap about the underlying mechanisms maintaining a delicate balance within this ecosystem. To bridge this knowledge gap, a holistic picture of the available information has been presented with a primary focus on the microbiota-metabolite relationship dynamics. The central theme of this article is the gut-brain axis and the participating microbial metabolites that impact cerebral functions.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1337368/fullmetabolitemicrobiomemetagenomicsholobiontfecal microbesgut brain axis |
| spellingShingle | Nabarun Chakraborty Metabolites: a converging node of host and microbe to explain meta-organism Frontiers in Microbiology metabolite microbiome metagenomics holobiont fecal microbes gut brain axis |
| title | Metabolites: a converging node of host and microbe to explain meta-organism |
| title_full | Metabolites: a converging node of host and microbe to explain meta-organism |
| title_fullStr | Metabolites: a converging node of host and microbe to explain meta-organism |
| title_full_unstemmed | Metabolites: a converging node of host and microbe to explain meta-organism |
| title_short | Metabolites: a converging node of host and microbe to explain meta-organism |
| title_sort | metabolites a converging node of host and microbe to explain meta organism |
| topic | metabolite microbiome metagenomics holobiont fecal microbes gut brain axis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1337368/full |
| work_keys_str_mv | AT nabarunchakraborty metabolitesaconvergingnodeofhostandmicrobetoexplainmetaorganism |