B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman Primates

B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman Primates

ABSTRACT We investigated the distribution, virulence, and pathogenic characteristics of mutated SARS-CoV-2 to clarify the association between virulence and the viral spreading ability of current and future circulating strains. Chinese rhesus macaques were infected with ancestral SARS-CoV-2 strain GD...

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Bibliographic Details
Main Authors: Yu Bai, Qian He, Jinghuan Yang, Shuaiyao Lu, Qunying Mao, Fan Gao, Lianlian Bian, Jialu Zhang, Chaoqiang An, Jianyang Liu, Xing Wu, Wenhai Yu, Zhongfang Wang, Xiaozhong Peng, Junzhi Wang, Zhenglun Liang, Miao Xu
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2 variant
viral distribution
virulence
viral shedding
nonhuman primate
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02263-22

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