Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction
ObjectiveTo study the associations of non-alcoholic fatty liver disease (NAFLD), chronic kidney disease (CKD), and serum uric acid (SUA) in patients with post–myocardial infarction (MI) patients, and the relationship of SUA with 12-year mortality risk.MethodsWe included 3,396 patients (60–80 years...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1240099/full |
| _version_ | 1797661908408467456 |
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| author | Luc Heerkens Anniek C. van Westing Trudy Voortman Isabella Kardys Eric Boersma Johanna M. Geleijnse |
| author_facet | Luc Heerkens Anniek C. van Westing Trudy Voortman Isabella Kardys Eric Boersma Johanna M. Geleijnse |
| author_sort | Luc Heerkens |
| collection | DOAJ |
| description | ObjectiveTo study the associations of non-alcoholic fatty liver disease (NAFLD), chronic kidney disease (CKD), and serum uric acid (SUA) in patients with post–myocardial infarction (MI) patients, and the relationship of SUA with 12-year mortality risk.MethodsWe included 3,396 patients (60–80 years old, 78% men) of the Alpha Omega Cohort. Multivariable prevalence ratios (PRs) were obtained for the association of NAFLD [fatty liver index (FLI), ≥77 (women) and ≥79 (men)] with CKD [estimated glomerular filtration rate (eGFR), <60 mL/min per 1.73 m2]. We calculated sensitivity and specificity of SUA to detect the (combined) presence and absence of NAFLD and CKD. Cause-specific mortality was monitored from enrolment (2002–2006) through December 2018. Hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality in SUA categories were obtained from multivariable Cox models.ResultsMedian baseline FLI was 67 (men, 68; women, 64), and mean ± SD eGFR was 81 ± 20 mL/min per 1.73 m2 (17% with CKD). Sex-specific FLI was associated with higher CKD prevalence (PRtertile3 vs. tertile1, 1.94; 95% confidence interval: 1.57, 2.39). Baseline SUA was 0.36 ± 0.09 mmol/L. With increasing SUA concentrations, specificity for the presence of NAFLD, CKD, or both increased, and sensitivity decreased. During 12 (interquartile range, 9–14) years of follow-up, 1,592 patients died (713 from CVD). HRs ranged from 1.08 (0.88, 1.32) for SUA ≤0.25 mmol/L to 2.13 (1.75, 2.60) for SUA >0.50 mmol/L vs. SUA >0.30–0.35 mmol/L for all-cause mortality. For CVD mortality, HRs ranged from 1.05 (0.77, 1.44) to 2.43 (1.83, 3.25).ConclusionsNAFLD and CKD were strongly associated, which was reflected by higher SUA concentrations. SUA was a strong predictor of 12-year mortality risk after MI. |
| first_indexed | 2024-03-11T18:52:27Z |
| format | Article |
| id | doaj.art-35234ef744c4473bb8fb9ed59abe6551 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T18:52:27Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-35234ef744c4473bb8fb9ed59abe65512023-10-11T07:43:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12400991240099Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarctionLuc Heerkens0Anniek C. van Westing1Trudy Voortman2Isabella Kardys3Eric Boersma4Johanna M. Geleijnse5Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, NetherlandsDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, NetherlandsDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, NetherlandsDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, NetherlandsObjectiveTo study the associations of non-alcoholic fatty liver disease (NAFLD), chronic kidney disease (CKD), and serum uric acid (SUA) in patients with post–myocardial infarction (MI) patients, and the relationship of SUA with 12-year mortality risk.MethodsWe included 3,396 patients (60–80 years old, 78% men) of the Alpha Omega Cohort. Multivariable prevalence ratios (PRs) were obtained for the association of NAFLD [fatty liver index (FLI), ≥77 (women) and ≥79 (men)] with CKD [estimated glomerular filtration rate (eGFR), <60 mL/min per 1.73 m2]. We calculated sensitivity and specificity of SUA to detect the (combined) presence and absence of NAFLD and CKD. Cause-specific mortality was monitored from enrolment (2002–2006) through December 2018. Hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality in SUA categories were obtained from multivariable Cox models.ResultsMedian baseline FLI was 67 (men, 68; women, 64), and mean ± SD eGFR was 81 ± 20 mL/min per 1.73 m2 (17% with CKD). Sex-specific FLI was associated with higher CKD prevalence (PRtertile3 vs. tertile1, 1.94; 95% confidence interval: 1.57, 2.39). Baseline SUA was 0.36 ± 0.09 mmol/L. With increasing SUA concentrations, specificity for the presence of NAFLD, CKD, or both increased, and sensitivity decreased. During 12 (interquartile range, 9–14) years of follow-up, 1,592 patients died (713 from CVD). HRs ranged from 1.08 (0.88, 1.32) for SUA ≤0.25 mmol/L to 2.13 (1.75, 2.60) for SUA >0.50 mmol/L vs. SUA >0.30–0.35 mmol/L for all-cause mortality. For CVD mortality, HRs ranged from 1.05 (0.77, 1.44) to 2.43 (1.83, 3.25).ConclusionsNAFLD and CKD were strongly associated, which was reflected by higher SUA concentrations. SUA was a strong predictor of 12-year mortality risk after MI.https://www.frontiersin.org/articles/10.3389/fendo.2023.1240099/fullnon-alcoholic fatty liver diseasekidney diseasesglomerular filtration rateuric acidmortality |
| spellingShingle | Luc Heerkens Anniek C. van Westing Trudy Voortman Isabella Kardys Eric Boersma Johanna M. Geleijnse Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction Frontiers in Endocrinology non-alcoholic fatty liver disease kidney diseases glomerular filtration rate uric acid mortality |
| title | Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction |
| title_full | Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction |
| title_fullStr | Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction |
| title_full_unstemmed | Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction |
| title_short | Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction |
| title_sort | serum uric acid is related to liver and kidney disease and 12 year mortality risk after myocardial infarction |
| topic | non-alcoholic fatty liver disease kidney diseases glomerular filtration rate uric acid mortality |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1240099/full |
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