Activation of astrocyte Gq pathway in hippocampal CA1 region attenuates anesthesia/surgery induced cognitive dysfunction in aged mice

Activation of astrocyte Gq pathway in hippocampal CA1 region attenuates anesthesia/surgery induced cognitive dysfunction in aged mice

The elderly are particularly vulnerable to brain dysfunction after fracture surgery, but the mechanism underlying the cognitive decline due to anesthesia/surgery is not well understood. In this study, we observed hippocampus-dependent cognitive impairment in aged mice undergoing anesthesia and tibia...

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Bibliographic Details
Main Authors: Xupeng Wang, Yanan Li, Juan Zhao, Jiaxu Yu, Qi Zhang, Fang Xu, Yahui Zhang, Qi Zhou, Chunping Yin, Zhiyong Hou, Qiujun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
POCD
astrocyte
synaptic plasticity
chemical genetics
aged mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1040569/full

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