Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report
Abstract Background Focal cortical dysplasia (FCD) is a common cause of drug-resistant epilepsy. Electroencephalography (EEG) biomarkers that predict good postoperative outcomes are essential for identifying patients with focal epilepsies. Case presentation We report the case of a 21-year-old female...
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Acta Epileptologica |
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| Online Access: | https://doi.org/10.1186/s42494-023-00131-6 |
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| author | Sofía S. Sánchez-Boluarte Wilfor Aguirre-Quispe Manuel Herrera Aramburú William O. Tatum Walter De La Cruz Ramírez |
| author_facet | Sofía S. Sánchez-Boluarte Wilfor Aguirre-Quispe Manuel Herrera Aramburú William O. Tatum Walter De La Cruz Ramírez |
| author_sort | Sofía S. Sánchez-Boluarte |
| collection | DOAJ |
| description | Abstract Background Focal cortical dysplasia (FCD) is a common cause of drug-resistant epilepsy. Electroencephalography (EEG) biomarkers that predict good postoperative outcomes are essential for identifying patients with focal epilepsies. Case presentation We report the case of a 21-year-old female with seizure onset at the age of 9, characterized by left-hand dystonic posturing and impaired awareness, which evolved to bilateral tonic-clonic seizures, evaluated in a neurological referral center in Lima, Peru. During 6-h video-EEG, interictal EEG revealing focal brief potentially ictal rhythmic discharges (BIRDs) over the right frontal central region, lasting less than 10 s. The ictal features were characterized by low-voltage fast activity over the same area. Brain magnetic resonance imaging (MRI) demonstrated a focal lesion of focal cortical dysplasia type II in the right frontal lobe. The patient underwent a lesionectomy guided by electrocorticography, which showed continuous polyspikes. BIRDs showing a brief burst of spikes lasting longer than 0.5 s, were also identified on intraoperative electrocorticography (ECoG) and helped define the extent of resection. The patient obtained an Engel Outcome Class IA at 6 years of follow-up. Conclusions The atypical BIRDs on ECoG can be used as a prognostic biomarker for prolonged seizure-freedom outcome in patients with epilepsy. Additional reports are needed in developing countries with and without brain MRI lesions to advance outpatient presurgical evaluations despite limited resources. |
| first_indexed | 2024-03-12T22:12:46Z |
| format | Article |
| id | doaj.art-35269c7b912b41089d521da330faed3b |
| institution | Directory Open Access Journal |
| issn | 2524-4434 |
| language | English |
| last_indexed | 2024-03-12T22:12:46Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Epileptologica |
| spelling | doaj.art-35269c7b912b41089d521da330faed3b2023-07-23T11:29:28ZengBMCActa Epileptologica2524-44342023-07-01511510.1186/s42494-023-00131-6Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case reportSofía S. Sánchez-Boluarte0Wilfor Aguirre-Quispe1Manuel Herrera Aramburú2William O. Tatum3Walter De La Cruz Ramírez4School of Medicine, Cesar Vallejo UniversityNeurosciences, Clinical Effectiveness and Public Health Research Group, Universidad Científica del SurDepartamento de Epilepsia, Instituto Nacional de Ciencias NeurológicasDepartment of Neurology, Mayo ClinicDepartamento de Epilepsia, Instituto Nacional de Ciencias NeurológicasAbstract Background Focal cortical dysplasia (FCD) is a common cause of drug-resistant epilepsy. Electroencephalography (EEG) biomarkers that predict good postoperative outcomes are essential for identifying patients with focal epilepsies. Case presentation We report the case of a 21-year-old female with seizure onset at the age of 9, characterized by left-hand dystonic posturing and impaired awareness, which evolved to bilateral tonic-clonic seizures, evaluated in a neurological referral center in Lima, Peru. During 6-h video-EEG, interictal EEG revealing focal brief potentially ictal rhythmic discharges (BIRDs) over the right frontal central region, lasting less than 10 s. The ictal features were characterized by low-voltage fast activity over the same area. Brain magnetic resonance imaging (MRI) demonstrated a focal lesion of focal cortical dysplasia type II in the right frontal lobe. The patient underwent a lesionectomy guided by electrocorticography, which showed continuous polyspikes. BIRDs showing a brief burst of spikes lasting longer than 0.5 s, were also identified on intraoperative electrocorticography (ECoG) and helped define the extent of resection. The patient obtained an Engel Outcome Class IA at 6 years of follow-up. Conclusions The atypical BIRDs on ECoG can be used as a prognostic biomarker for prolonged seizure-freedom outcome in patients with epilepsy. Additional reports are needed in developing countries with and without brain MRI lesions to advance outpatient presurgical evaluations despite limited resources.https://doi.org/10.1186/s42494-023-00131-6ElectrocorticographyCortical dysplasia-focal epilepsy syndromeDrug-resistant epilepsyFrontal lobe epilepsy |
| spellingShingle | Sofía S. Sánchez-Boluarte Wilfor Aguirre-Quispe Manuel Herrera Aramburú William O. Tatum Walter De La Cruz Ramírez Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report Acta Epileptologica Electrocorticography Cortical dysplasia-focal epilepsy syndrome Drug-resistant epilepsy Frontal lobe epilepsy |
| title | Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report |
| title_full | Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report |
| title_fullStr | Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report |
| title_full_unstemmed | Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report |
| title_short | Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report |
| title_sort | brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection a case report |
| topic | Electrocorticography Cortical dysplasia-focal epilepsy syndrome Drug-resistant epilepsy Frontal lobe epilepsy |
| url | https://doi.org/10.1186/s42494-023-00131-6 |
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