Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality
Odorants binding to olfactory receptor neurons (ORNs) trigger bursts of action potentials, providing the brain with its only experience of the olfactory environment. Our recordings made in vivo from locust ORNs showed that odor-elicited firing patterns comprise four distinct response motifs, each de...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2023-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/79152 |
| _version_ | 1811165034281172992 |
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| author | Brian Kim Seth Haney Ana P Milan Shruti Joshi Zane Aldworth Nikolai Rulkov Alexander T Kim Maxim Bazhenov Mark A Stopfer |
| author_facet | Brian Kim Seth Haney Ana P Milan Shruti Joshi Zane Aldworth Nikolai Rulkov Alexander T Kim Maxim Bazhenov Mark A Stopfer |
| author_sort | Brian Kim |
| collection | DOAJ |
| description | Odorants binding to olfactory receptor neurons (ORNs) trigger bursts of action potentials, providing the brain with its only experience of the olfactory environment. Our recordings made in vivo from locust ORNs showed that odor-elicited firing patterns comprise four distinct response motifs, each defined by a reliable temporal profile. Different odorants could elicit different response motifs from a given ORN, a property we term motif switching. Further, each motif undergoes its own form of sensory adaptation when activated by repeated plume-like odor pulses. A computational model constrained by our recordings revealed that organizing responses into multiple motifs provides substantial benefits for classifying odors and processing complex odor plumes: each motif contributes uniquely to encode the plume’s composition and structure. Multiple motifs and motif switching further improve odor classification by expanding coding dimensionality. Our model demonstrated that these response features could provide benefits for olfactory navigation, including determining the distance to an odor source. |
| first_indexed | 2024-04-10T15:31:03Z |
| format | Article |
| id | doaj.art-35273e50c95843e7a60d57bb991cd1c6 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-10T15:31:03Z |
| publishDate | 2023-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-35273e50c95843e7a60d57bb991cd1c62023-02-13T16:47:48ZengeLife Sciences Publications LtdeLife2050-084X2023-01-011210.7554/eLife.79152Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionalityBrian Kim0Seth Haney1Ana P Milan2Shruti Joshi3Zane Aldworth4https://orcid.org/0000-0002-0647-8465Nikolai Rulkov5Alexander T Kim6Maxim Bazhenov7https://orcid.org/0000-0002-1936-0570Mark A Stopfer8https://orcid.org/0000-0001-9200-1884Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, United States; Brown University - National Institutes of Health Graduate Partnership Program, Providence, United StatesDepartment of Medicine, University of California, San Diego, San Diego, United StatesDepartment of Clinical Neurophysiology and MEG Center, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Medicine, University of California, San Diego, San Diego, United StatesEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, United StatesBiocircuits Institute, University of California, San Diego, La Jolla, United StatesEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, United StatesDepartment of Medicine, University of California, San Diego, San Diego, United StatesEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, United StatesOdorants binding to olfactory receptor neurons (ORNs) trigger bursts of action potentials, providing the brain with its only experience of the olfactory environment. Our recordings made in vivo from locust ORNs showed that odor-elicited firing patterns comprise four distinct response motifs, each defined by a reliable temporal profile. Different odorants could elicit different response motifs from a given ORN, a property we term motif switching. Further, each motif undergoes its own form of sensory adaptation when activated by repeated plume-like odor pulses. A computational model constrained by our recordings revealed that organizing responses into multiple motifs provides substantial benefits for classifying odors and processing complex odor plumes: each motif contributes uniquely to encode the plume’s composition and structure. Multiple motifs and motif switching further improve odor classification by expanding coding dimensionality. Our model demonstrated that these response features could provide benefits for olfactory navigation, including determining the distance to an odor source.https://elifesciences.org/articles/79152odorsensory encodingcombinatorialcomputational modelingSchistocerca americanainformation |
| spellingShingle | Brian Kim Seth Haney Ana P Milan Shruti Joshi Zane Aldworth Nikolai Rulkov Alexander T Kim Maxim Bazhenov Mark A Stopfer Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality eLife odor sensory encoding combinatorial computational modeling Schistocerca americana information |
| title | Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality |
| title_full | Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality |
| title_fullStr | Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality |
| title_full_unstemmed | Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality |
| title_short | Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality |
| title_sort | olfactory receptor neurons generate multiple response motifs increasing coding space dimensionality |
| topic | odor sensory encoding combinatorial computational modeling Schistocerca americana information |
| url | https://elifesciences.org/articles/79152 |
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