sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis
INTRODUCTION: Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the Americas. METHOD: Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneous...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2006-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000400011 |
| _version_ | 1818560755756171264 |
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| author | Dorta-Contreras Alberto Juan Lewczuc Piotr Noris-García Elena Interián-Morales María Teresa Magraner Tarrau María Esther Padilla-Docal Bárbara Escobar-Pérez Xiomara |
| author_facet | Dorta-Contreras Alberto Juan Lewczuc Piotr Noris-García Elena Interián-Morales María Teresa Magraner Tarrau María Esther Padilla-Docal Bárbara Escobar-Pérez Xiomara |
| author_sort | Dorta-Contreras Alberto Juan |
| collection | DOAJ |
| description | INTRODUCTION: Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the Americas. METHOD: Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneously in the first diagnostic puncture at admission. RESULTS: All cases showed typical findings on the routine CSF and serum analysis: increased CSF total protein, increased Q (CSF/serum) albumin accompanied by eosinophilia in CSF. No intrathecal synthesis of immunoglobulins was found. Mean serum and CSF sICAM-1 values were 337.4 and 3.97 ng/mL. Qalbumin and QsICAM-1 mean values were 4.1 and 6.2 respectively. In 50% of the patients an increased brain-derived fraction of sICAM-1 was found. CONCLUSION: It may be suggested that a dynamic of the sICAM-1 brain derived fraction is perhaps associated to the immune response in the evolution of the disease.sICAM-1 may be an agent in negative feedback for eosinophils passage through the blood-CSF barrier into the inflammatory brain response. |
| first_indexed | 2024-12-14T00:42:20Z |
| format | Article |
| id | doaj.art-35280bf231384c7dad426d261c6d97b2 |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-12-14T00:42:20Z |
| publishDate | 2006-01-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-35280bf231384c7dad426d261c6d97b22022-12-21T23:24:18ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272006-01-01643A589591sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensisDorta-Contreras Alberto JuanLewczuc PiotrNoris-García ElenaInterián-Morales María TeresaMagraner Tarrau María EstherPadilla-Docal BárbaraEscobar-Pérez XiomaraINTRODUCTION: Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the Americas. METHOD: Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneously in the first diagnostic puncture at admission. RESULTS: All cases showed typical findings on the routine CSF and serum analysis: increased CSF total protein, increased Q (CSF/serum) albumin accompanied by eosinophilia in CSF. No intrathecal synthesis of immunoglobulins was found. Mean serum and CSF sICAM-1 values were 337.4 and 3.97 ng/mL. Qalbumin and QsICAM-1 mean values were 4.1 and 6.2 respectively. In 50% of the patients an increased brain-derived fraction of sICAM-1 was found. CONCLUSION: It may be suggested that a dynamic of the sICAM-1 brain derived fraction is perhaps associated to the immune response in the evolution of the disease.sICAM-1 may be an agent in negative feedback for eosinophils passage through the blood-CSF barrier into the inflammatory brain response.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000400011Angiostrongylus cantonensisalbuminsICAM-1blood-cerebrospinal fluid barriereosinophilsmeningoencephalitis |
| spellingShingle | Dorta-Contreras Alberto Juan Lewczuc Piotr Noris-García Elena Interián-Morales María Teresa Magraner Tarrau María Esther Padilla-Docal Bárbara Escobar-Pérez Xiomara sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis Arquivos de Neuro-Psiquiatria Angiostrongylus cantonensis albumin sICAM-1 blood-cerebrospinal fluid barrier eosinophils meningoencephalitis |
| title | sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis |
| title_full | sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis |
| title_fullStr | sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis |
| title_full_unstemmed | sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis |
| title_short | sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis |
| title_sort | sicam 1 in meningoencephalitis due to angiostrongylus cantonensis |
| topic | Angiostrongylus cantonensis albumin sICAM-1 blood-cerebrospinal fluid barrier eosinophils meningoencephalitis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000400011 |
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