Dissipative Particle Dynamics Investigation of the Transport of Salicylic Acid through a Simulated In Vitro Skin Permeation Model

Dissipative Particle Dynamics Investigation of the Transport of Salicylic Acid through a Simulated In Vitro Skin Permeation Model

Permeation models are often used to determine diffusion properties of a drug through a membrane as it is released from a delivery system. In order to circumvent problematic in vivo studies, diffusion studies can be performed in vitro, using (semi-)synthetic membranes. In this study salicylic acid pe...

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Bibliographic Details
Main Authors: Daniel P. Otto, Johann Combrinck, Anja Otto, Louwrens R. Tiedt, Melgardt M. de Villiers
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceuticals
Subjects:
skin
nitrocellulose membrane
interaction parameter
diffusion
atomistic molecular dynamics
dissipative particle dynamics
Online Access:https://www.mdpi.com/1424-8247/11/4/134

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