Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis
IntroductionFunctional neuroimaging could provide abundant information of underling pathophysiological mechanisms of the clinical triad including motor, cognitive and psychiatric impairment in Huntington's Disease (HD).MethodsWe performed a voxel-based meta-analysis using anisotropic effect siz...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1124158/full |
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| author | Sirui Zhang Sirui Zhang Sirui Zhang Junyu Lin Junyu Lin Yangfan Cheng Yangfan Cheng Yanbin Hou Yanbin Hou Huifang Shang Huifang Shang |
| author_facet | Sirui Zhang Sirui Zhang Sirui Zhang Junyu Lin Junyu Lin Yangfan Cheng Yangfan Cheng Yanbin Hou Yanbin Hou Huifang Shang Huifang Shang |
| author_sort | Sirui Zhang |
| collection | DOAJ |
| description | IntroductionFunctional neuroimaging could provide abundant information of underling pathophysiological mechanisms of the clinical triad including motor, cognitive and psychiatric impairment in Huntington's Disease (HD).MethodsWe performed a voxel-based meta-analysis using anisotropic effect size-signed differential mapping (AES-SDM) method.Results6 studies (78 symptomatic HD, 102 premanifest HD and 131 healthy controls) were included in total. Altered resting-state brain activity was primarily detected in the bilateral medial part of superior frontal gyrus, bilateral anterior cingulate/paracingulate gyrus, left insula, left striatum, right cortico-spinal projections area, right inferior temporal gyrus area, right thalamus, right cerebellum and right gyrus rectus area. Premanifest and symptomatic HD patients showed different alterative pattern in the subgroup analyses.DiscussionThe robust and consistent abnormalities in the specific brain regions identified in the current study could help to understand the pathophysiology of HD and explore reliable neuroimaging biomarkers for monitoring disease progression, or even predicting the onset of premanifest HD patients. |
| first_indexed | 2024-04-09T20:37:42Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T20:37:42Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-352a34b12903466aaa3deb41ff4028962023-03-30T06:36:05ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-03-011410.3389/fneur.2023.11241581124158Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysisSirui Zhang0Sirui Zhang1Sirui Zhang2Junyu Lin3Junyu Lin4Yangfan Cheng5Yangfan Cheng6Yanbin Hou7Yanbin Hou8Huifang Shang9Huifang Shang10Department of Neurology, West China Hospital, Rare Disease Center, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurology, West China Hospital, Rare Disease Center, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurology, West China Hospital, Rare Disease Center, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurology, West China Hospital, Rare Disease Center, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurology, West China Hospital, Rare Disease Center, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, ChinaIntroductionFunctional neuroimaging could provide abundant information of underling pathophysiological mechanisms of the clinical triad including motor, cognitive and psychiatric impairment in Huntington's Disease (HD).MethodsWe performed a voxel-based meta-analysis using anisotropic effect size-signed differential mapping (AES-SDM) method.Results6 studies (78 symptomatic HD, 102 premanifest HD and 131 healthy controls) were included in total. Altered resting-state brain activity was primarily detected in the bilateral medial part of superior frontal gyrus, bilateral anterior cingulate/paracingulate gyrus, left insula, left striatum, right cortico-spinal projections area, right inferior temporal gyrus area, right thalamus, right cerebellum and right gyrus rectus area. Premanifest and symptomatic HD patients showed different alterative pattern in the subgroup analyses.DiscussionThe robust and consistent abnormalities in the specific brain regions identified in the current study could help to understand the pathophysiology of HD and explore reliable neuroimaging biomarkers for monitoring disease progression, or even predicting the onset of premanifest HD patients.https://www.frontiersin.org/articles/10.3389/fneur.2023.1124158/fullHuntington's diseasemeta-analysisresting-statefunctional magnetic resonance imagingpsychoradiology |
| spellingShingle | Sirui Zhang Sirui Zhang Sirui Zhang Junyu Lin Junyu Lin Yangfan Cheng Yangfan Cheng Yanbin Hou Yanbin Hou Huifang Shang Huifang Shang Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis Frontiers in Neurology Huntington's disease meta-analysis resting-state functional magnetic resonance imaging psychoradiology |
| title | Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis |
| title_full | Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis |
| title_fullStr | Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis |
| title_full_unstemmed | Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis |
| title_short | Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis |
| title_sort | aberrant resting state brain activity in huntington s disease a voxel based meta analysis |
| topic | Huntington's disease meta-analysis resting-state functional magnetic resonance imaging psychoradiology |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1124158/full |
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